| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 622,112 | 1,411,000 | +788,888 | 0.47 | 0.79 | +0.32 | buy |
| MILLENNIUM MANAGEMENT LLC | 62,556 | 324,550 | +261,994 | 0.00 | 0.01 | +0.01 | buy |
| Newtyn Management, LLC | 218,087 | 366,000 | +147,913 | 1.74 | 2.35 | +0.61 | buy |
| Stonepine Capital Management, LLC | 261,870 | 393,634 | +131,764 | 4.60 | 10.05 | +5.45 | buy |
| Prosight Management, LP | 827,294 | 931,512 | +104,218 | 13.50 | 8.34 | -5.16 | buy |
| Hudson Bay Capital Management LP | 332,000 | 432,400 | +100,400 | 0.12 | 0.12 | +0.00 | buy |
| Finepoint Capital LP | 458,659 | 503,759 | +45,100 | 6.45 | 4.16 | -2.29 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 678,877 | 715,240 | +36,363 | 0.02 | 0.02 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,126 | 22,714 | +12,588 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 6,744 | 16,744 | +10,000 | 0.11 | 0.24 | +0.13 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 603 | 5,328 | +4,725 | 0.00 | 0.00 | +0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 3,000 | 7,717 | +4,717 | 0.03 | 0.06 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 4,401 | +4,401 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 263,200 | 266,500 | +3,300 | 0.02 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 12,820 | 15,186 | +2,366 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,265 | 3,769 | +1,504 | 0.02 | 0.02 | -0.00 | buy |
| Aquatic Capital Management LLC | 5,700 | 6,900 | +1,200 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,995 | 12,090 | +1,095 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 45,722 | 46,712 | +990 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 3,036 | 3,764 | +728 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 75 | 787 | +712 | 0.00 | 0.01 | +0.01 | buy |
| SIGNATUREFD, LLC | 1,970 | 2,614 | +644 | 0.00 | 0.00 | -0.00 | buy |
| Rise Advisors, LLC | 0 | 425 | +425 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 385 | +385 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 23,471 | 23,711 | +240 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,706 | 1,834 | +128 | 0.01 | 0.00 | -0.00 | buy |
| RFP Financial Group LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 1,147 | 1,209 | +62 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR INVESTMENT ADVISORY, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 22,518 | 22,518 | 0 | 0.07 | 0.06 | -0.01 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 130,175 | 130,175 | 0 | 1.27 | 0.95 | -0.31 | hold |
| 683 Capital Management, LLC | 58,000 | 58,000 | 0 | 0.24 | 0.19 | -0.05 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 8 | 8 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 47,200 | 47,200 | 0 | 0.09 | 0.06 | -0.02 | hold |
| LMR Partners LLP | 10,768 | 10,768 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EcoR1 Capital, LLC | 5,756,268 | 5,756,268 | 0 | 6.08 | 4.71 | -1.37 | hold |
| NewEdge Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bogart Wealth, LLC | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestal Point Capital, LP | 130,000 | 130,000 | 0 | 0.56 | 0.35 | -0.21 | hold |
| Erste Asset Management GmbH | 14,000 | 14,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 6,500 | 6,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,235 | 11,235 | 0 | 0.01 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 594 | 554 | -40 | 0.00 | 0.00 | -0.00 | sell |
| SUMMIT SECURITIES GROUP LLC | 46 | 0 | -46 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 173 | 122 | -51 | 0.00 | 0.00 | -0.00 | sell |
| Planned Solutions, Inc. | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| WealthCollab, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Blue Trust, Inc. | 106 | 0 | -106 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 38,432 | 38,183 | -249 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Hong Kong Ltd | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 400 | 89 | -311 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,161 | 775 | -386 | 0.01 | 0.01 | -0.01 | sell |
| US BANCORP \DE\ | 821 | 359 | -462 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,934 | 797 | -1,137 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 106,842 | 104,218 | -2,624 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 4,095 | 311 | -3,784 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6,684 | 0 | -6,684 | 0.02 | 0.00 | -0.02 | sell |
| SEGALL BRYANT & HAMILL, LLC | 874,728 | 868,042 | -6,686 | 0.69 | 0.52 | -0.16 | sell |
| GTS SECURITIES LLC | 8,563 | 0 | -8,563 | 0.01 | 0.00 | -0.01 | sell |
| Walleye Capital LLC | 8,998 | 0 | -8,998 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 11,566 | 0 | -11,566 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 12,953 | 0 | -12,953 | 0.19 | 0.00 | -0.19 | sell |
| GROUP ONE TRADING LLC | 19,970 | 2,997 | -16,973 | 0.03 | 0.00 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 495,217 | 474,883 | -20,334 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 20,812 | 0 | -20,812 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 75,640 | 51,673 | -23,967 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 45,407 | 20,088 | -25,319 | 0.02 | 0.01 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 119,085 | 91,485 | -27,600 | 0.00 | 0.00 | -0.00 | sell |
| OLD MISSION CAPITAL LLC | 33,980 | 0 | -33,980 | 0.04 | 0.00 | -0.04 | sell |
| JANE STREET GROUP, LLC | 42,682 | 0 | -42,682 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,844 | 8,284 | -43,560 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 49,960 | 2,036 | -47,924 | 0.06 | 0.00 | -0.06 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 56,159 | 7,106 | -49,053 | 0.01 | 0.00 | -0.01 | sell |
| BVF INC/IL | 1,915,109 | 1,863,809 | -51,300 | 1.95 | 1.65 | -0.30 | sell |
| FMR LLC | 4,233,803 | 4,174,517 | -59,286 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 127,849 | 54,737 | -73,112 | 0.01 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 154,649 | 53,700 | -100,949 | 0.02 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 111,330 | 0 | -111,330 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 262,384 | 21,497 | -240,887 | 0.01 | 0.00 | -0.01 | sell |