| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 622,112 | 1,411,000 | +788,888 | 0.47 | 0.79 | +0.32 | buy |
| Newtyn Management, LLC | 218,087 | 366,000 | +147,913 | 1.74 | 2.35 | +0.61 | buy |
| Stonepine Capital Management, LLC | 261,870 | 393,634 | +131,764 | 4.60 | 10.05 | +5.45 | buy |
| Prosight Management, LP | 827,294 | 931,512 | +104,218 | 13.50 | 8.34 | -5.16 | buy |
| Hudson Bay Capital Management LP | 332,000 | 432,400 | +100,400 | 0.09 | 0.08 | -0.01 | buy |
| Finepoint Capital LP | 458,659 | 503,759 | +45,100 | 5.88 | 4.16 | -1.72 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 678,877 | 715,240 | +36,363 | 0.02 | 0.02 | -0.00 | buy |
| Monaco Asset Management SAM | 6,744 | 16,744 | +10,000 | 0.11 | 0.24 | +0.13 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 3,000 | 7,717 | +4,717 | 0.03 | 0.06 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 2,265 | 3,769 | +1,504 | 0.02 | 0.02 | -0.00 | buy |
| ALPS ADVISORS INC | 45,722 | 46,712 | +990 | 0.01 | 0.01 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 874,728 | 868,042 | -6,686 | 0.69 | 0.52 | -0.16 | sell |
| Optiver Holding B.V. | 49,960 | 2,036 | -47,924 | 0.06 | 0.00 | -0.06 | sell |
| BVF INC/IL | 1,915,109 | 1,863,809 | -51,300 | 1.95 | 1.65 | -0.30 | sell |