| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 2,161,200 | 3,961,797 | +1,800,597 | 3.93 | 5.51 | +1.57 | buy |
| Prosight Management, LP | 1,025,000 | 1,314,898 | +289,898 | 7.79 | 10.85 | +3.06 | buy |
| 683 Capital Management, LLC | 70,000 | 110,100 | +40,100 | 0.12 | 0.19 | +0.07 | buy |
| Monaco Asset Management SAM | 15,000 | 36,036 | +21,036 | 0.18 | 0.46 | +0.27 | buy |
| Vestal Point Capital, LP | 180,000 | 200,000 | +20,000 | 0.29 | 0.36 | +0.07 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 9,417 | 13,517 | +4,100 | 0.09 | 0.13 | +0.03 | buy |
| DME Capital Management, LP | 479,363 | 482,746 | +3,383 | 0.68 | 0.61 | -0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,135 | 19,305 | +170 | 0.04 | 0.05 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 293 | 357 | +64 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,962 | 2,931 | -31 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 53,455 | 48,286 | -5,169 | 0.01 | 0.01 | -0.00 | sell |
| Finepoint Capital LP | 674,762 | 656,587 | -18,175 | 1.13 | 1.26 | +0.12 | sell |
| SEGALL BRYANT & HAMILL, LLC | 685,867 | 651,461 | -34,406 | 0.26 | 0.25 | -0.01 | sell |
| Deep Track Capital, LP | 780,778 | 741,068 | -39,710 | 0.81 | 0.60 | -0.20 | sell |
| Newtyn Management, LLC | 270,000 | 200,000 | -70,000 | 1.29 | 0.79 | -0.50 | sell |
| Stonepine Capital Management, LLC | 200,000 | 93,968 | -106,032 | 4.44 | 2.30 | -2.14 | sell |
| BVF INC/IL | 1,569,422 | 1,454,422 | -115,000 | 1.46 | 1.49 | +0.03 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 631,210 | 147,210 | -484,000 | 0.01 | 0.00 | -0.01 | sell |