| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 2,161,200 | 3,961,797 | +1,800,597 | 3.93 | 5.51 | +1.57 | buy |
| Prosight Management, LP | 1,025,000 | 1,314,898 | +289,898 | 7.90 | 10.85 | +2.96 | buy |
| JANE STREET GROUP, LLC | 11,137 | 110,783 | +99,646 | 0.00 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 84,307 | +84,307 | 0.00 | 0.08 | +0.08 | buy |
| OLD MISSION CAPITAL LLC | 0 | 75,043 | +75,043 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 0 | 63,020 | +63,020 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 0 | 53,786 | +53,786 | 0.00 | 0.67 | +0.67 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 49,161 | +49,161 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 43,500 | +43,500 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 70,000 | 110,100 | +40,100 | 0.19 | 0.28 | +0.09 | buy |
| Centiva Capital, LP | 0 | 38,551 | +38,551 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 22,454 | 59,606 | +37,152 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 296,100 | 330,800 | +34,700 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 75,579 | 109,011 | +33,432 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 831 | 31,860 | +31,029 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 30,408 | +30,408 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 22,912 | +22,912 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 15,000 | 36,036 | +21,036 | 0.18 | 0.46 | +0.27 | buy |
| MILLENNIUM MANAGEMENT LLC | 42,275 | 63,064 | +20,789 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 180,000 | 200,000 | +20,000 | 0.29 | 0.36 | +0.07 | buy |
| ABC ARBITRAGE SA | 0 | 13,241 | +13,241 | 0.00 | 0.06 | +0.06 | buy |
| Verition Fund Management LLC | 17,689 | 30,075 | +12,386 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 11,360 | +11,360 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 554,300 | 565,000 | +10,700 | 0.09 | 0.09 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 8,154 | +8,154 | 0.00 | 0.00 | +0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 9,417 | 13,517 | +4,100 | 0.09 | 0.13 | +0.03 | buy |
| DME Capital Management, LP | 479,363 | 482,746 | +3,383 | 0.68 | 0.61 | -0.06 | buy |
| GROUP ONE TRADING LLC | 0 | 3,135 | +3,135 | 0.00 | 0.00 | +0.00 | buy |
| Wealthquest Corp | 0 | 2,962 | +2,962 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 25,852 | 27,839 | +1,987 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,724 | +1,724 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 830 | 1,385 | +555 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 455 | +455 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,135 | 19,305 | +170 | 0.04 | 0.05 | +0.00 | buy |
| Crossmark Global Holdings, Inc. | 49,163 | 49,332 | +169 | 0.02 | 0.02 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 293 | 357 | +64 | 0.00 | 0.00 | +0.00 | buy |
| Hexagon Capital Partners LLC | 73 | 133 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 465 | 489 | +24 | 0.00 | 0.00 | -0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 26,140 | 26,140 | 0 | 0.08 | 0.07 | -0.01 | hold |
| PRINCIPAL SECURITIES, INC. | 128 | 128 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 130,175 | 130,175 | 0 | 0.91 | 0.93 | +0.02 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 37,111 | 37,111 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Arax Advisory Partners | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 155,006 | 155,006 | 0 | 0.17 | 0.23 | +0.06 | hold |
| NewEdge Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blue Trust, Inc. | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| GILEAD SCIENCES, INC. | 16,707,477 | 16,707,477 | 0 | 29.77 | 35.50 | +5.74 | hold |
| Wilmington Savings Fund Society, FSB | 74 | 74 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 21 | 9 | -12 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,962 | 2,931 | -31 | 0.01 | 0.01 | -0.00 | sell |
| VAN ECK ASSOCIATES CORP | 1,153 | 1,111 | -42 | 0.00 | 0.00 | -0.00 | sell |
| Physician Wealth Advisors, Inc. | 139 | 0 | -139 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 29,855 | 29,698 | -157 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 159 | 0 | -159 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 309 | 150 | -159 | 0.00 | 0.00 | -0.00 | sell |
| Rise Advisors, LLC | 425 | 0 | -425 | 0.01 | 0.00 | -0.01 | sell |
| QRG CAPITAL MANAGEMENT, INC. | 10,455 | 9,697 | -758 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 1,117 | 256 | -861 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 930 | 0 | -930 | 0.02 | 0.00 | -0.02 | sell |
| RHUMBLINE ADVISERS | 4,823 | 3,888 | -935 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 8,972 | 7,428 | -1,544 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 2,233 | 404 | -1,829 | 0.01 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 26,418 | 24,025 | -2,393 | 0.02 | 0.02 | -0.00 | sell |
| SIGNATUREFD, LLC | 6,836 | 1,864 | -4,972 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 53,455 | 48,286 | -5,169 | 0.01 | 0.01 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 9,740 | 4,429 | -5,311 | 0.02 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 70,413 | 64,700 | -5,713 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 7,819 | 0 | -7,819 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 9,257 | 0 | -9,257 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 10,768 | 0 | -10,768 | 0.01 | 0.00 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,235 | 0 | -11,235 | 0.00 | 0.00 | -0.00 | sell |
| WEALTHEDGE INVESTMENT ADVISORS, LLC | 11,301 | 0 | -11,301 | 0.14 | 0.00 | -0.14 | sell |
| Finepoint Capital LP | 674,762 | 656,587 | -18,175 | 2.14 | 2.78 | +0.64 | sell |
| XTX Topco Ltd | 19,833 | 0 | -19,833 | 0.05 | 0.00 | -0.05 | sell |
| Creative Planning | 20,963 | 0 | -20,963 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 24,731 | 0 | -24,731 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 685,867 | 651,461 | -34,406 | 0.26 | 0.25 | -0.01 | sell |
| FMR LLC | 1,594,809 | 1,556,856 | -37,953 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 780,778 | 741,068 | -39,710 | 0.81 | 0.60 | -0.20 | sell |
| Woodline Partners LP | 45,899 | 0 | -45,899 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 49,373 | 0 | -49,373 | 0.00 | 0.00 | -0.00 | sell |
| Newtyn Management, LLC | 270,000 | 200,000 | -70,000 | 1.29 | 0.79 | -0.50 | sell |
| Stonepine Capital Management, LLC | 200,000 | 93,968 | -106,032 | 4.44 | 2.30 | -2.14 | sell |
| BVF INC/IL | 1,569,422 | 1,454,422 | -115,000 | 1.46 | 1.49 | +0.03 | sell |
| MORGAN STANLEY | 144,137 | 0 | -144,137 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 424,664 | 253,951 | -170,713 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 631,210 | 147,210 | -484,000 | 0.01 | 0.00 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,411,000 | 0 | -1,411,000 | 0.74 | 0.00 | -0.74 | sell |