| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 931,512 | 1,349,980 | +418,468 | 8.34 | 10.00 | +1.65 | buy |
| Newtyn Management, LLC | 366,000 | 500,000 | +134,000 | 2.35 | 2.33 | -0.02 | buy |
| CITADEL ADVISORS LLC | 21,497 | 153,936 | +132,439 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 113,729 | +113,729 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 432,400 | 525,000 | +92,600 | 0.12 | 0.10 | -0.02 | buy |
| Stonepine Capital Management, LLC | 393,634 | 485,000 | +91,366 | 10.05 | 10.97 | +0.91 | buy |
| DME Capital Management, LP | 159,828 | 234,828 | +75,000 | 0.24 | 0.28 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 55,609 | +55,609 | 0.00 | 0.14 | +0.14 | buy |
| Vestal Point Capital, LP | 130,000 | 180,000 | +50,000 | 0.35 | 0.33 | -0.01 | buy |
| Finepoint Capital LP | 503,759 | 542,762 | +39,003 | 4.16 | 3.82 | -0.34 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 35,263 | +35,263 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,284 | 30,842 | +22,558 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 19,883 | +19,883 | 0.00 | 0.04 | +0.04 | buy |
| Creative Planning | 0 | 18,407 | +18,407 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 324,550 | 341,639 | +17,089 | 0.01 | 0.01 | -0.00 | buy |
| OLD MISSION CAPITAL LLC | 0 | 14,124 | +14,124 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 12,715 | +12,715 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 58,000 | 70,000 | +12,000 | 0.19 | 0.18 | -0.01 | buy |
| XTX Topco Ltd | 0 | 11,452 | +11,452 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 385 | 9,178 | +8,793 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 8,632 | +8,632 | 0.00 | 0.02 | +0.02 | buy |
| Optiver Holding B.V. | 2,036 | 7,948 | +5,912 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 715,240 | 720,240 | +5,000 | 0.02 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 46,712 | 51,451 | +4,739 | 0.01 | 0.01 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,834 | 6,549 | +4,715 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 797 | 5,479 | +4,682 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 266,500 | 270,800 | +4,300 | 0.01 | 0.01 | -0.00 | buy |
| Monaco Asset Management SAM | 16,744 | 20,999 | +4,255 | 0.24 | 0.26 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 104,218 | 106,024 | +1,806 | 0.00 | 0.00 | -0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 7,717 | 9,417 | +1,700 | 0.06 | 0.09 | +0.03 | buy |
| SIGNATUREFD, LLC | 2,614 | 3,872 | +1,258 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 3,764 | 4,578 | +814 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 89 | 837 | +748 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 607 | +607 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,328 | 5,817 | +489 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 787 | 1,233 | +446 | 0.01 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 271 | +271 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 155 | +155 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 554 | 640 | +86 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 311 | 372 | +61 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 359 | 390 | +31 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 48 | 67 | +19 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 6 | 14 | +8 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,411,000 | 1,411,000 | 0 | 0.79 | 0.58 | -0.21 | hold |
| MOODY NATIONAL BANK TRUST DIVISION | 22,518 | 22,518 | 0 | 0.06 | 0.04 | -0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 12,090 | 12,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 130,175 | 130,175 | 0 | 0.95 | 0.77 | -0.18 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 8 | 8 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 47,200 | 47,200 | 0 | 0.06 | 0.05 | -0.02 | hold |
| LMR Partners LLP | 10,768 | 10,768 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EcoR1 Capital, LLC | 5,756,268 | 5,756,268 | 0 | 4.71 | 4.36 | -0.34 | hold |
| Rise Advisors, LLC | 425 | 425 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RFP Financial Group LLC | 68 | 68 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 14,000 | 14,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 23,711 | 23,711 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VAN ECK ASSOCIATES CORP | 1,209 | 1,209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,235 | 11,235 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOR INVESTMENT ADVISORY, LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Bogart Wealth, LLC | 49 | 0 | -49 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 130 | 32 | -98 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 122 | 5 | -117 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 775 | 523 | -252 | 0.01 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 2,997 | 2,100 | -897 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 6,900 | 5,800 | -1,100 | 0.01 | 0.01 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,769 | 2,389 | -1,380 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 4,401 | 0 | -4,401 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 6,500 | 0 | -6,500 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 7,106 | 0 | -7,106 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 38,183 | 28,774 | -9,409 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 91,485 | 79,835 | -11,650 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 15,186 | 844 | -14,342 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 20,088 | 0 | -20,088 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 22,714 | 0 | -22,714 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 54,737 | 30,206 | -24,531 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 51,673 | 16,780 | -34,893 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 53,700 | 0 | -53,700 | 0.01 | 0.00 | -0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 868,042 | 799,079 | -68,963 | 0.52 | 0.35 | -0.17 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 474,883 | 345,050 | -129,833 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 1,863,809 | 1,569,422 | -294,387 | 1.65 | 1.09 | -0.56 | sell |
| FMR LLC | 4,174,517 | 2,887,831 | -1,286,686 | 0.01 | 0.00 | -0.00 | sell |