| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Madison Avenue Partners, LP | 0 | 1,877,011 | +1,877,011 | 0.00 | 3.51 | +3.51 | buy |
| EcoR1 Capital, LLC | 155,006 | 1,036,945 | +881,939 | 0.23 | 1.72 | +1.49 | buy |
| Prosight Management, LP | 1,314,898 | 1,773,649 | +458,751 | 10.85 | 12.11 | +1.25 | buy |
| Point72 Asset Management, L.P. | 0 | 341,500 | +341,500 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 330,800 | 464,700 | +133,900 | 0.01 | 0.02 | +0.00 | buy |
| UBS Group AG | 109,011 | 238,524 | +129,513 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 63,064 | 190,709 | +127,645 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 63,020 | 153,185 | +90,165 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 85,401 | +85,401 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 80,862 | +80,862 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,385 | 79,135 | +77,750 | 0.00 | 0.06 | +0.06 | buy |
| MORGAN STANLEY | 0 | 66,164 | +66,164 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 56,731 | +56,731 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 38,551 | 94,905 | +56,354 | 0.06 | 0.18 | +0.12 | buy |
| Optiver Holding B.V. | 30,408 | 78,929 | +48,521 | 0.03 | 0.06 | +0.03 | buy |
| XTX Topco Ltd | 0 | 39,803 | +39,803 | 0.00 | 0.05 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,961,797 | 3,990,111 | +28,314 | 5.51 | 5.65 | +0.14 | buy |
| Jump Financial, LLC | 0 | 24,730 | +24,730 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 21,866 | +21,866 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 0 | 19,990 | +19,990 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 12,371 | +12,371 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 11,707 | +11,707 | 0.00 | 0.00 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 9,312 | +9,312 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 8,538 | +8,538 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 31,860 | 40,169 | +8,309 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 8,234 | +8,234 | 0.00 | 0.08 | +0.08 | buy |
| Headlands Technologies LLC | 0 | 7,973 | +7,973 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 7,851 | +7,851 | 0.00 | 0.00 | +0.00 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 9,697 | 15,096 | +5,399 | 0.00 | 0.00 | +0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 13,517 | 16,917 | +3,400 | 0.13 | 0.13 | +0.00 | buy |
| Verition Fund Management LLC | 30,075 | 31,313 | +1,238 | 0.00 | 0.01 | +0.00 | buy |
| State of Wyoming | 0 | 1,018 | +1,018 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 404 | 821 | +417 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 408 | +408 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 40 | 433 | +393 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 27,839 | 28,102 | +263 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 9 | 135 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 489 | 572 | +83 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 128 | 186 | +58 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,931 | 2,976 | +45 | 0.01 | 0.01 | +0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 72 | 90 | +18 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,305 | 19,305 | 0 | 0.05 | 0.05 | +0.00 | hold |
| DAFNA Capital Management LLC | 130,175 | 130,175 | 0 | 0.93 | 1.01 | +0.08 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DME Capital Management, LP | 482,746 | 482,746 | 0 | 0.61 | 0.58 | -0.03 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 37,111 | 37,111 | 0 | 0.04 | 0.04 | +0.00 | hold |
| NewEdge Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Monaco Asset Management SAM | 36,036 | 36,036 | 0 | 0.46 | 0.38 | -0.08 | hold |
| Blue Trust, Inc. | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 357 | 357 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| VAN ECK ASSOCIATES CORP | 1,111 | 1,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GILEAD SCIENCES, INC. | 16,707,477 | 16,707,477 | 0 | 35.50 | 36.53 | +1.03 | hold |
| Wilmington Savings Fund Society, FSB | 74 | 74 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 3,888 | 3,855 | -33 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 455 | 409 | -46 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 150 | 94 | -56 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 74 | 0 | -74 | 0.00 | 0.00 | -0.00 | sell |
| Hexagon Capital Partners LLC | 133 | 0 | -133 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 256 | 103 | -153 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 1,864 | 1,565 | -299 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 7,428 | 6,549 | -879 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 1,724 | 0 | -1,724 | 0.00 | 0.00 | -0.00 | sell |
| Crossmark Global Holdings, Inc. | 49,332 | 47,442 | -1,890 | 0.02 | 0.02 | -0.00 | sell |
| Wealthquest Corp | 2,962 | 0 | -2,962 | 0.01 | 0.00 | -0.01 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 11,360 | 8,382 | -2,978 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 3,135 | 0 | -3,135 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 147,210 | 143,310 | -3,900 | 0.00 | 0.00 | +0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 4,429 | 0 | -4,429 | 0.00 | 0.00 | -0.00 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 26,140 | 20,849 | -5,291 | 0.07 | 0.05 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,912 | 15,183 | -7,729 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 8,154 | 0 | -8,154 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,556,856 | 1,547,028 | -9,828 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 64,700 | 54,705 | -9,995 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 48,286 | 35,378 | -12,908 | 0.01 | 0.01 | -0.00 | sell |
| ABC ARBITRAGE SA | 13,241 | 0 | -13,241 | 0.06 | 0.00 | -0.06 | sell |
| Aquatic Capital Management LLC | 24,025 | 10,709 | -13,316 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 49,161 | 21,659 | -27,502 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 253,951 | 226,056 | -27,895 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 29,698 | 776 | -28,922 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 59,606 | 30,306 | -29,300 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 43,500 | 7,500 | -36,000 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 565,000 | 515,000 | -50,000 | 0.09 | 0.09 | +0.00 | sell |
| Tejara Capital Ltd | 53,786 | 0 | -53,786 | 0.67 | 0.00 | -0.67 | sell |
| OLD MISSION CAPITAL LLC | 75,043 | 0 | -75,043 | 0.04 | 0.00 | -0.04 | sell |
| JANE STREET GROUP, LLC | 110,783 | 30,775 | -80,008 | 0.01 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 84,307 | 0 | -84,307 | 0.08 | 0.00 | -0.08 | sell |
| Stonepine Capital Management, LLC | 93,968 | 0 | -93,968 | 2.30 | 0.00 | -2.30 | sell |
| 683 Capital Management, LLC | 110,100 | 0 | -110,100 | 0.28 | 0.00 | -0.28 | sell |
| SEGALL BRYANT & HAMILL, LLC | 651,461 | 501,077 | -150,384 | 0.25 | 0.20 | -0.05 | sell |
| Newtyn Management, LLC | 200,000 | 0 | -200,000 | 0.79 | 0.00 | -0.79 | sell |
| Vestal Point Capital, LP | 200,000 | 0 | -200,000 | 0.36 | 0.00 | -0.36 | sell |
| Finepoint Capital LP | 656,587 | 0 | -656,587 | 2.78 | 0.00 | -2.78 | sell |