| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 155,006 | 1,036,945 | +881,939 | 0.23 | 1.72 | +1.49 | buy |
| Prosight Management, LP | 1,314,898 | 1,773,649 | +458,751 | 10.85 | 12.11 | +1.25 | buy |
| Optiver Holding B.V. | 30,408 | 78,929 | +48,521 | 0.03 | 0.06 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,961,797 | 3,990,111 | +28,314 | 5.51 | 5.65 | +0.14 | buy |
| ALPS ADVISORS INC | 48,286 | 35,378 | +12,908 | 0.01 | 0.01 | 0.00 | sell |
| BAROMETER CAPITAL MANAGEMENT INC. | 13,517 | 16,917 | +3,400 | 0.13 | 0.13 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,931 | 2,976 | +45 | 0.01 | 0.01 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 147,210 | 143,310 | -3,900 | 0.00 | 0.00 | +0.00 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 26,140 | 20,849 | -5,291 | 0.07 | 0.05 | -0.02 | sell |
| SEGALL BRYANT & HAMILL, LLC | 651,461 | 501,077 | -150,384 | 0.25 | 0.20 | -0.05 | sell |