| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 0 | 800,000 | +800,000 | 0.00 | 2.58 | +2.58 | buy |
| TANG CAPITAL MANAGEMENT LLC | 55,609 | 700,000 | +644,391 | 0.14 | 1.44 | +1.30 | buy |
| DME Capital Management, LP | 234,828 | 479,363 | +244,535 | 0.28 | 0.57 | +0.29 | buy |
| Optiver Holding B.V. | 7,948 | 69,396 | +61,448 | 0.00 | 0.05 | +0.05 | buy |
| Crossmark Global Holdings, Inc. | 0 | 37,386 | +37,386 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 270,800 | 291,679 | +20,879 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,241 | +16,241 | 0.00 | 0.00 | +0.00 | buy |
| Finepoint Capital LP | 542,762 | 557,762 | +15,000 | 3.82 | 1.95 | -1.87 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 8,632 | 19,135 | +10,503 | 0.02 | 0.04 | +0.02 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 0 | 8,589 | +8,589 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 6,549 | 11,268 | +4,719 | 0.01 | 0.02 | +0.01 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 22,518 | 26,140 | +3,622 | 0.04 | 0.08 | +0.04 | buy |
| Creative Planning | 18,407 | 21,870 | +3,463 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 3,872 | 6,413 | +2,541 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,389 | 3,899 | +1,510 | 0.01 | 0.01 | +0.00 | buy |
| Headlands Technologies LLC | 1,233 | 2,742 | +1,509 | 0.00 | 0.01 | +0.01 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 9,417 | 10,717 | +1,300 | 0.09 | 0.09 | -0.00 | buy |
| GAMMA Investing LLC | 523 | 1,259 | +736 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 23,711 | 24,421 | +710 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 837 | 1,497 | +660 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,817 | 6,148 | +331 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 271 | 518 | +247 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 4,578 | 4,823 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 607 | 733 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Planned Solutions, Inc. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 67 | 106 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Jaffetilchin Investment Partners, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Hexagon Capital Partners LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 372 | 375 | +3 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,411,000 | 1,411,000 | 0 | 0.58 | 0.61 | +0.03 | hold |
| BVF INC/IL | 1,569,422 | 1,569,422 | 0 | 1.09 | 1.32 | +0.23 | hold |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DAFNA Capital Management LLC | 130,175 | 130,175 | 0 | 0.77 | 0.89 | +0.11 | hold |
| 683 Capital Management, LLC | 70,000 | 70,000 | 0 | 0.18 | 0.21 | +0.02 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 47,200 | 47,200 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Newtyn Management, LLC | 500,000 | 500,000 | 0 | 2.33 | 2.21 | -0.12 | hold |
| LMR Partners LLP | 10,768 | 10,768 | 0 | 0.01 | 0.01 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 32 | 32 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Monaco Asset Management SAM | 20,999 | 20,999 | 0 | 0.26 | 0.25 | -0.01 | hold |
| Rise Advisors, LLC | 425 | 425 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vestal Point Capital, LP | 180,000 | 180,000 | 0 | 0.33 | 0.41 | +0.08 | hold |
| Erste Asset Management GmbH | 14,000 | 14,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 720,240 | 720,240 | 0 | 0.01 | 0.02 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,235 | 11,235 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 5 | 0 | -5 | 0.00 | 0.00 | 0.00 | sell |
| CWM, LLC | 8 | 0 | -8 | 0.00 | 0.00 | 0.00 | sell |
| NewEdge Advisors, LLC | 14 | 6 | -8 | 0.00 | 0.00 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 155 | 139 | -16 | 0.00 | 0.00 | -0.00 | sell |
| RFP Financial Group LLC | 68 | 0 | -68 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 77 | 0 | -77 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 390 | 299 | -91 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 30,206 | 30,048 | -158 | 0.00 | 0.00 | +0.00 | sell |
| VAN ECK ASSOCIATES CORP | 1,209 | 753 | -456 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 640 | 0 | -640 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 844 | 0 | -844 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 51,451 | 49,898 | -1,553 | 0.01 | 0.01 | +0.00 | sell |
| GROUP ONE TRADING LLC | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 11,452 | 8,341 | -3,111 | 0.02 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 12,090 | 7,819 | -4,271 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,479 | 357 | -5,122 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 5,800 | 0 | -5,800 | 0.01 | 0.00 | -0.01 | sell |
| Stonepine Capital Management, LLC | 485,000 | 478,659 | -6,341 | 10.97 | 8.71 | -2.26 | sell |
| SIMPLEX TRADING, LLC | 9,178 | 0 | -9,178 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 12,715 | 0 | -12,715 | 0.00 | 0.00 | -0.00 | sell |
| OLD MISSION CAPITAL LLC | 14,124 | 0 | -14,124 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 525,000 | 510,000 | -15,000 | 0.10 | 0.10 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 35,263 | 18,770 | -16,493 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 16,780 | 0 | -16,780 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 19,883 | 0 | -19,883 | 0.04 | 0.00 | -0.04 | sell |
| AMERIPRISE FINANCIAL INC | 106,024 | 80,825 | -25,199 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 79,835 | 52,018 | -27,817 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 28,774 | 0 | -28,774 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 113,729 | 84,355 | -29,374 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,842 | 0 | -30,842 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 341,639 | 267,354 | -74,285 | 0.01 | 0.01 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 799,079 | 705,648 | -93,431 | 0.35 | 0.28 | -0.07 | sell |
| CITADEL ADVISORS LLC | 153,936 | 57,974 | -95,962 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 1,349,980 | 1,028,843 | -321,137 | 10.00 | 7.51 | -2.49 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 345,050 | 0 | -345,050 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,887,831 | 1,598,912 | -1,288,919 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 5,756,268 | 155,006 | -5,601,262 | 4.36 | 0.15 | -4.21 | sell |