| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 622,112 | +622,112 | 0.00 | 0.47 | +0.47 | buy |
| SEGALL BRYANT & HAMILL, LLC | 737,991 | 874,728 | +136,737 | 0.29 | 0.69 | +0.39 | buy |
| Prosight Management, LP | 730,207 | 827,294 | +97,087 | 8.00 | 13.50 | +5.51 | buy |
| MORGAN STANLEY | 23,350 | 111,330 | +87,980 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 60,175 | 130,175 | +70,000 | 0.65 | 1.27 | +0.62 | buy |
| Optiver Holding B.V. | 0 | 49,960 | +49,960 | 0.00 | 0.06 | +0.06 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 7,456 | 56,159 | +48,703 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,710 | 51,844 | +45,134 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 75,167 | 119,085 | +43,918 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 42,682 | +42,682 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,379 | 62,556 | +40,177 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 90,686 | 127,849 | +37,163 | 0.00 | 0.01 | +0.00 | buy |
| OLD MISSION CAPITAL LLC | 0 | 33,980 | +33,980 | 0.00 | 0.04 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 7,107 | 38,432 | +31,325 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 23,249 | 45,407 | +22,158 | 0.01 | 0.02 | +0.01 | buy |
| GROUP ONE TRADING LLC | 96 | 19,970 | +19,874 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 476,665 | 495,217 | +18,552 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 57,345 | 75,640 | +18,295 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 89,344 | 106,842 | +17,498 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 14,000 | +14,000 | 0.00 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 669,677 | 678,877 | +9,200 | 0.02 | 0.02 | +0.00 | buy |
| Walleye Capital LLC | 0 | 8,998 | +8,998 | 0.00 | 0.01 | +0.01 | buy |
| GTS SECURITIES LLC | 0 | 8,563 | +8,563 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 7,316 | 11,566 | +4,250 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 4,095 | +4,095 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 2,000 | 5,700 | +3,700 | 0.00 | 0.01 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 18,839 | 22,518 | +3,679 | 0.04 | 0.07 | +0.03 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 0 | 3,000 | +3,000 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,934 | +1,934 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 495 | 2,265 | +1,770 | 0.00 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 19,447 | 20,812 | +1,365 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 22,127 | 23,471 | +1,344 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,095 | 10,995 | +900 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,103 | 1,970 | +867 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 319 | 821 | +502 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 6,000 | 6,500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 307 | 603 | +296 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,445 | 1,706 | +261 | 0.00 | 0.01 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 956 | 1,147 | +191 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 106 | +106 | 0.00 | 0.00 | +0.00 | buy |
| Planned Solutions, Inc. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6,680 | 6,684 | +4 | 0.02 | 0.02 | +0.00 | buy |
| BVF INC/IL | 1,915,109 | 1,915,109 | 0 | 1.78 | 1.95 | +0.16 | hold |
| RHUMBLINE ADVISERS | 3,036 | 3,036 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 683 Capital Management, LLC | 58,000 | 58,000 | 0 | 0.20 | 0.24 | +0.03 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 8 | 8 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 47,200 | 47,200 | 0 | 0.09 | 0.09 | -0.00 | hold |
| LMR Partners LLP | 10,768 | 10,768 | 0 | 0.01 | 0.01 | +0.00 | hold |
| EcoR1 Capital, LLC | 5,756,268 | 5,756,268 | 0 | 6.77 | 6.08 | -0.70 | hold |
| Finepoint Capital LP | 458,659 | 458,659 | 0 | 7.89 | 6.45 | -1.44 | hold |
| NewEdge Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bogart Wealth, LLC | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,235 | 11,235 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SUMMIT SECURITIES GROUP LLC | 186 | 46 | -140 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 790 | 594 | -196 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 13,647 | 12,953 | -694 | 0.22 | 0.19 | -0.03 | sell |
| Monaco Asset Management SAM | 8,458 | 6,744 | -1,714 | 0.15 | 0.11 | -0.04 | sell |
| TWO SIGMA INVESTMENTS, LP | 12,200 | 10,126 | -2,074 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 2,492 | 0 | -2,492 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 48,312 | 45,722 | -2,590 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 3,662 | 0 | -3,662 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 6,200 | 0 | -6,200 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 19,149 | 12,820 | -6,329 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 10,888 | 0 | -10,888 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 350,000 | 332,000 | -18,000 | 0.12 | 0.12 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 281,800 | 263,200 | -18,600 | 0.02 | 0.02 | -0.00 | sell |
| Point72 Asset Management, L.P. | 173,300 | 154,649 | -18,651 | 0.02 | 0.02 | -0.00 | sell |
| Carlson Capital, L.P. | 25,000 | 0 | -25,000 | 0.07 | 0.00 | -0.07 | sell |
| Newtyn Management, LLC | 275,000 | 218,087 | -56,913 | 2.34 | 1.74 | -0.60 | sell |
| FMR LLC | 4,317,676 | 4,233,803 | -83,873 | 0.01 | 0.01 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 89,650 | 0 | -89,650 | 0.44 | 0.00 | -0.44 | sell |
| CITADEL ADVISORS LLC | 469,868 | 262,384 | -207,484 | 0.02 | 0.01 | -0.01 | sell |
| Stonepine Capital Management, LLC | 802,544 | 261,870 | -540,674 | 9.21 | 4.60 | -4.61 | sell |