| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 2,161,200 | +1,461,200 | 1.44 | 3.93 | +2.49 | buy |
| Deep Track Capital, LP | 0 | 780,778 | +780,778 | 0.00 | 0.81 | +0.81 | buy |
| Finepoint Capital LP | 557,762 | 674,762 | +117,000 | 1.95 | 2.14 | +0.19 | buy |
| UBS Group AG | 0 | 75,579 | +75,579 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 84,355 | 144,137 | +59,782 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 45,899 | +45,899 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 510,000 | 554,300 | +44,300 | 0.10 | 0.09 | -0.01 | buy |
| Aquatic Capital Management LLC | 0 | 26,418 | +26,418 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 17,689 | +17,689 | 0.00 | 0.00 | +0.00 | buy |
| Crossmark Global Holdings, Inc. | 37,386 | 49,163 | +11,777 | 0.02 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 8,341 | 19,833 | +11,492 | 0.02 | 0.05 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 11,137 | +11,137 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 9,257 | +9,257 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 291,679 | 296,100 | +4,421 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 18,770 | 22,454 | +3,684 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 49,898 | 53,455 | +3,557 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,148 | 8,972 | +2,824 | 0.00 | 0.00 | +0.00 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 8,589 | 10,455 | +1,866 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 24,421 | 25,852 | +1,431 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 1,259 | 2,233 | +974 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 100 | 831 | +731 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 357 | 830 | +473 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 6,413 | 6,836 | +423 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 753 | 1,153 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 159 | +159 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| Hexagon Capital Partners LLC | 5 | 73 | +68 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 106 | 128 | +22 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 299 | 309 | +10 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,411,000 | 1,411,000 | 0 | 0.61 | 0.74 | +0.13 | hold |
| BVF INC/IL | 1,569,422 | 1,569,422 | 0 | 1.32 | 1.46 | +0.14 | hold |
| MOODY NATIONAL BANK TRUST DIVISION | 26,140 | 26,140 | 0 | 0.08 | 0.08 | -0.01 | hold |
| RHUMBLINE ADVISERS | 4,823 | 4,823 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 7,819 | 7,819 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,135 | 19,135 | 0 | 0.04 | 0.04 | +0.00 | hold |
| DAFNA Capital Management LLC | 130,175 | 130,175 | 0 | 0.89 | 0.91 | +0.02 | hold |
| 683 Capital Management, LLC | 70,000 | 70,000 | 0 | 0.21 | 0.19 | -0.02 | hold |
| CACTI ASSET MANAGEMENT LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DME Capital Management, LP | 479,363 | 479,363 | 0 | 0.57 | 0.68 | +0.10 | hold |
| LMR Partners LLP | 10,768 | 10,768 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Arax Advisory Partners | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 155,006 | 155,006 | 0 | 0.15 | 0.17 | +0.02 | hold |
| NewEdge Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rise Advisors, LLC | 425 | 425 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Vestal Point Capital, LP | 180,000 | 180,000 | 0 | 0.41 | 0.29 | -0.12 | hold |
| Erste Asset Management GmbH | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 74 | 74 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,235 | 11,235 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jaffetilchin Investment Partners, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Planned Solutions, Inc. | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 139 | 21 | -118 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 30,048 | 29,855 | -193 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 733 | 465 | -268 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 375 | 0 | -375 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 1,497 | 1,117 | -380 | 0.00 | 0.00 | -0.00 | sell |
| Blue Trust, Inc. | 518 | 10 | -508 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 21,870 | 20,963 | -907 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,899 | 2,962 | -937 | 0.01 | 0.01 | -0.00 | sell |
| BAROMETER CAPITAL MANAGEMENT INC. | 10,717 | 9,417 | -1,300 | 0.09 | 0.09 | +0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 11,268 | 9,740 | -1,528 | 0.02 | 0.02 | -0.00 | sell |
| Headlands Technologies LLC | 2,742 | 0 | -2,742 | 0.01 | 0.00 | -0.01 | sell |
| Prosight Management, LP | 1,028,843 | 1,025,000 | -3,843 | 7.51 | 7.90 | +0.39 | sell |
| FMR LLC | 1,598,912 | 1,594,809 | -4,103 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 20,999 | 15,000 | -5,999 | 0.25 | 0.18 | -0.07 | sell |
| CITADEL ADVISORS LLC | 57,974 | 49,373 | -8,601 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 47,200 | 37,111 | -10,089 | 0.05 | 0.04 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 80,825 | 70,413 | -10,412 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 16,241 | 0 | -16,241 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 705,648 | 685,867 | -19,781 | 0.28 | 0.26 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 52,018 | 24,731 | -27,287 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 69,396 | 0 | -69,396 | 0.05 | 0.00 | -0.05 | sell |
| BlackRock, Inc. | 504,266 | 424,664 | -79,602 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 720,240 | 631,210 | -89,030 | 0.02 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 267,354 | 42,275 | -225,079 | 0.01 | 0.00 | -0.01 | sell |
| Newtyn Management, LLC | 500,000 | 270,000 | -230,000 | 2.21 | 1.29 | -0.92 | sell |
| Stonepine Capital Management, LLC | 478,659 | 200,000 | -278,659 | 8.71 | 4.44 | -4.27 | sell |
| Logos Global Management LP | 800,000 | 0 | -800,000 | 2.58 | 0.00 | -2.58 | sell |