| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 4,166,000 | +4,166,000 | 0.00 | 0.18 | +0.18 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 3,700,000 | +3,700,000 | 0.00 | 0.27 | +0.27 | buy |
| QVT Financial LP | 2,313,702 | 4,515,709 | +2,202,007 | 0.65 | 0.73 | +0.07 | buy |
| Siren, L.L.C. | 0 | 2,082,000 | +2,082,000 | 0.00 | 0.21 | +0.21 | buy |
| Yu Fan | 0 | 2,070,000 | +2,070,000 | 0.00 | 3.79 | +3.79 | buy |
| EcoR1 Capital, LLC | 345,253 | 2,082,000 | +1,736,747 | 0.04 | 0.22 | +0.18 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 1,849,402 | 3,410,402 | +1,561,000 | 5.87 | 7.04 | +1.17 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,400 | 315,284 | +199,884 | 0.01 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 35,595 | 107,520 | +71,925 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 46,698 | +46,698 | 0.00 | 0.08 | +0.08 | buy |
| SG Americas Securities, LLC | 0 | 36,774 | +36,774 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 62,035 | 97,312 | +35,277 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 217,294 | 235,840 | +18,546 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 456,022 | 462,122 | +6,100 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,555 | +2,555 | 0.00 | 0.00 | +0.00 | buy |
| Semmax Financial Advisors Inc. | 0 | 297 | +297 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 765,992 | 765,992 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.13 | 0.08 | -0.05 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 1,512 | 1,512 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ally Bridge Group (NY) LLC | 817,939 | 817,939 | 0 | 2.21 | 1.31 | -0.90 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 7.77 | 5.93 | -1.84 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CITIGROUP INC | 75 | 75 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 68,737 | 68,737 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 197 | 160 | -37 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 77 | 0 | -77 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 428 | 20 | -408 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 558 | 0 | -558 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 243,890 | 241,249 | -2,641 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,897 | 10,197 | -2,700 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 4,724 | 930 | -3,794 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 26,400 | 21,800 | -4,600 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 91,151 | 86,323 | -4,828 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 6,589 | 0 | -6,589 | 0.00 | 0.00 | -0.00 | sell |
| ACORN CAPITAL ADVISORS, LLC | 1,147,052 | 1,139,363 | -7,689 | 1.95 | 1.35 | -0.60 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 11,609 | 0 | -11,609 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 13,245 | 0 | -13,245 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 14,484 | 0 | -14,484 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 61,686 | 40,969 | -20,717 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 68,555 | 43,158 | -25,397 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 41,600 | 0 | -41,600 | 0.00 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 63,564 | 0 | -63,564 | 0.03 | 0.00 | -0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 173,998 | 44,823 | -129,175 | 0.00 | 0.00 | -0.00 | sell |
| Peapod Lane Capital LLC | 442,942 | 241,403 | -201,539 | 1.39 | 0.48 | -0.90 | sell |
| BML Capital Management, LLC | 2,100,000 | 1,890,245 | -209,755 | 4.12 | 2.72 | -1.39 | sell |
| Soleus Capital Management, L.P. | 333,227 | 0 | -333,227 | 0.08 | 0.00 | -0.08 | sell |