| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 333,227 | +333,227 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 226,085 | +226,085 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 49,579 | 154,270 | +104,691 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 99,931 | +99,931 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 32,195 | 82,361 | +50,166 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 48,960 | +48,960 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 318,139 | 352,483 | +34,344 | 0.38 | 0.28 | -0.10 | buy |
| Centiva Capital, LP | 0 | 33,100 | +33,100 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 28,172 | +28,172 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 27,580 | +27,580 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 27,489 | +27,489 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 25,176 | +25,176 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 20,630 | +20,630 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 19,019 | +19,019 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 15,749 | +15,749 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 15,300 | +15,300 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,009 | 16,944 | +12,935 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 12,071 | +12,071 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,499 | 13,668 | +10,169 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 57,807 | 63,564 | +5,757 | 0.02 | 0.02 | -0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 4,888 | +4,888 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 4,874 | +4,874 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,451 | 2,484 | +1,033 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 830 | +830 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 3,714 | 4,294 | +580 | 0.00 | 0.00 | -0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 232 | +232 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 25 | 161 | +136 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 10 | 131 | +121 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 35,595 | 35,656 | +61 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 1,849,402 | 1,849,402 | 0 | 2.81 | 2.28 | -0.54 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.08 | 0.06 | -0.02 | hold |
| Schonfeld Strategic Advisors LLC | 41,700 | 41,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 509,572 | 509,572 | 0 | 0.09 | 0.07 | -0.02 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 7.50 | 4.53 | -2.97 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Avior Wealth Management, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 1,000 | 943 | -57 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 158,804 | 158,680 | -124 | 0.00 | 0.00 | -0.00 | sell |
| Private Wealth Management Group, LLC | 285 | 0 | -285 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 36,597 | 36,197 | -400 | 0.01 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 502 | 0 | -502 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 3,597 | 2,757 | -840 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 970 | 0 | -970 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,086 | 0 | -1,086 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,484 | 0 | -1,484 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,842 | 0 | -1,842 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 7,993 | 0 | -7,993 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,731 | 141 | -10,590 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,692 | 0 | -10,692 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 11,356 | 8 | -11,348 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 25,386 | 9,487 | -15,899 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 21,355 | 0 | -21,355 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 41,088 | 17,796 | -23,292 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 517,576 | 493,136 | -24,440 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 26,500 | 0 | -26,500 | 0.01 | 0.00 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 37,075 | 0 | -37,075 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 43,858 | 0 | -43,858 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 856,836 | 765,992 | -90,844 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 543,722 | 439,222 | -104,500 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 200,000 | 80,000 | -120,000 | 0.05 | 0.01 | -0.04 | sell |
| STRS OHIO | 155,500 | 0 | -155,500 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 161,196 | 8 | -161,188 | 0.01 | 0.00 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 399,231 | 206,443 | -192,788 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 375,147 | 68,737 | -306,410 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 464,466 | 0 | -464,466 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 526,329 | 0 | -526,329 | 0.17 | 0.00 | -0.17 | sell |