| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 765,992 | 1,315,285 | +549,293 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 235,840 | 372,334 | +136,494 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 105,310 | +105,310 | 0.00 | 0.00 | +0.00 | buy |
| QVT Financial LP | 4,515,709 | 4,615,709 | +100,000 | 0.73 | 1.15 | +0.42 | buy |
| Squarepoint Ops LLC | 0 | 61,366 | +61,366 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 241,249 | 298,320 | +57,071 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,103 | +11,103 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 86,323 | 92,275 | +5,952 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,555 | 4,098 | +1,543 | 0.00 | 0.00 | +0.00 | buy |
| Peapod Lane Capital LLC | 241,403 | 242,210 | +807 | 0.48 | 0.45 | -0.03 | buy |
| ORBIMED ADVISORS LLC | 4,166,000 | 4,166,000 | 0 | 0.18 | 0.20 | +0.02 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 315,284 | 315,284 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 160 | 160 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,000 | 3,700,000 | 0 | 0.27 | 0.26 | -0.01 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 3,410,402 | 3,410,402 | 0 | 7.04 | 8.90 | +1.86 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Yu Fan | 2,070,000 | 2,070,000 | 0 | 3.79 | 5.29 | +1.50 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ally Bridge Group (NY) LLC | 817,939 | 817,939 | 0 | 1.31 | 1.27 | -0.04 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 5.93 | 100.00 | +94.07 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 2,082,000 | 2,082,000 | 0 | 0.21 | 0.20 | -0.01 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,139,363 | 1,139,363 | 0 | 1.35 | 1.39 | +0.04 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STATE STREET CORP | 68,737 | 68,737 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 20 | 19 | -1 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 75 | 0 | -75 | 0.00 | 0.00 | -0.00 | sell |
| Semmax Financial Advisors Inc. | 297 | 0 | -297 | 0.04 | 0.00 | -0.04 | sell |
| FEDERATED HERMES, INC. | 930 | 358 | -572 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 1,512 | 386 | -1,126 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 462,122 | 458,222 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,197 | 0 | -10,197 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 21,800 | 0 | -21,800 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 107,520 | 70,749 | -36,771 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 36,774 | 0 | -36,774 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 40,969 | 0 | -40,969 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 43,158 | 0 | -43,158 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 44,823 | 0 | -44,823 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 46,698 | 0 | -46,698 | 0.08 | 0.00 | -0.08 | sell |
| CITADEL ADVISORS LLC | 97,312 | 0 | -97,312 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 2,082,000 | 1,091,417 | -990,583 | 0.22 | 0.12 | -0.10 | sell |
| BML Capital Management, LLC | 1,890,245 | 0 | -1,890,245 | 2.72 | 0.00 | -2.72 | sell |