| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Yu Fan | 2,070,000 | 4,861,314 | +2,791,314 | 7.36 | 20.63 | +13.27 | buy |
| BlackRock, Inc. | 351,385 | 1,922,828 | +1,571,443 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 3,410,402 | 4,685,912 | +1,275,510 | 8.37 | 14.96 | +6.59 | buy |
| ADAR1 Capital Management, LLC | 128,503 | 1,341,394 | +1,212,891 | 0.03 | 0.29 | +0.26 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,000 | 4,300,000 | +600,000 | 0.35 | 0.41 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 457,540 | 899,780 | +442,240 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 2,082,000 | 2,337,102 | +255,102 | 0.20 | 0.22 | +0.02 | buy |
| STATE STREET CORP | 160,382 | 386,982 | +226,600 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 107,266 | 264,689 | +157,423 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 281,497 | 436,614 | +155,117 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 126,758 | +126,758 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 70,101 | 170,883 | +100,782 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 82,632 | +82,632 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 939,369 | 1,021,037 | +81,668 | 0.62 | 0.81 | +0.19 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 78,832 | +78,832 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 78,832 | +78,832 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 309,674 | 380,406 | +70,732 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 51,840 | +51,840 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 43,799 | +43,799 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 40,800 | +40,800 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 39,179 | +39,179 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 31,668 | +31,668 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 28,026 | 57,129 | +29,103 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 27,174 | +27,174 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 26,609 | +26,609 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 24,529 | +24,529 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 24,363 | +24,363 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 273,482 | 296,612 | +23,130 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 18,700 | +18,700 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 14,942 | +14,942 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 14,479 | +14,479 | 0.00 | 0.00 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 10,838 | +10,838 | 0.00 | 0.04 | +0.04 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 10,205 | +10,205 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,044 | +10,044 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,033 | +10,033 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,159 | 15,019 | +8,860 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 202 | 6,944 | +6,742 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 647 | 6,433 | +5,786 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 30,090 | 33,420 | +3,330 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,162 | +3,162 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,945 | +2,945 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,555 | +2,555 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 48,307 | 48,993 | +686 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 654 | +654 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 23 | 317 | +294 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 145 | +145 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| QVT Financial LP | 4,615,709 | 4,615,709 | 0 | 1.26 | 1.35 | +0.10 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.10 | 0.12 | +0.02 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ally Bridge Group (NY) LLC | 817,939 | 817,939 | 0 | 2.80 | 4.83 | +2.02 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,139,363 | 1,139,363 | 0 | 1.12 | 1.42 | +0.31 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 386 | 0 | -386 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 306,800 | 303,306 | -3,494 | 0.07 | 0.08 | +0.01 | sell |
| XTX Topco Ltd | 22,983 | 18,522 | -4,461 | 0.00 | 0.00 | -0.00 | sell |
| AMES NATIONAL CORP | 4,571 | 0 | -4,571 | 0.80 | 0.00 | -0.80 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,283 | 0 | -10,283 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 11,500 | 0 | -11,500 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 12,589 | 0 | -12,589 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 428,622 | 413,822 | -14,800 | 0.00 | 0.00 | +0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 22,291 | 0 | -22,291 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 27,011 | 0 | -27,011 | 0.02 | 0.00 | -0.02 | sell |
| BAILARD, INC. | 31,398 | 0 | -31,398 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 34,935 | 0 | -34,935 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215,284 | 165,284 | -50,000 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 57,597 | 0 | -57,597 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 91,852 | 0 | -91,852 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 151,110 | 0 | -151,110 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 203,465 | 0 | -203,465 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 4,166,000 | 3,934,296 | -231,704 | 0.31 | 0.34 | +0.03 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 550,441 | 288,117 | -262,324 | 0.00 | 0.00 | -0.00 | sell |