| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.42 | +2.42 | buy |
| EcoR1 Capital, LLC | 0 | 1,845,253 | +1,845,253 | 0.00 | 0.13 | +0.13 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 93,300 | +93,300 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 352,483 | 438,760 | +86,277 | 0.28 | 0.40 | +0.13 | buy |
| Affinity Asset Advisors, LLC | 0 | 47,019 | +47,019 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 26,400 | +26,400 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 439,222 | 461,822 | +22,600 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 16,917 | +16,917 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 15,300 | 31,600 | +16,300 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,591 | +15,591 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 14,495 | +14,495 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 206,443 | 208,748 | +2,305 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,512 | +1,512 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 4,294 | 4,823 | +529 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 765,992 | 765,992 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marquette Asset Management, LLC | 63,564 | 63,564 | 0 | 0.02 | 0.02 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 1,849,402 | 1,849,402 | 0 | 2.28 | 3.09 | +0.81 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.06 | 0.09 | +0.03 | hold |
| Schonfeld Strategic Advisors LLC | 41,700 | 41,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Soleus Capital Management, L.P. | 333,227 | 333,227 | 0 | 0.04 | 0.06 | +0.01 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 4.53 | 4.89 | +0.36 | hold |
| Catalyst Funds Management Pty Ltd | 4,100 | 4,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STATE STREET CORP | 68,737 | 68,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 54 | 0 | -54 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 35,656 | 35,595 | -61 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 131 | 0 | -131 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 161 | 25 | -136 | 0.00 | 0.00 | 0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 141 | 0 | -141 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,484 | 2,339 | -145 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 830 | 0 | -830 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 943 | 0 | -943 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,757 | 81 | -2,676 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 4,874 | 1,009 | -3,865 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 4,888 | 77 | -4,811 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 27,489 | 21,097 | -6,392 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,135 | 0 | -8,135 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 9,487 | 0 | -9,487 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 20,630 | 10,510 | -10,120 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,668 | 1,793 | -11,875 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 12,071 | 0 | -12,071 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 25,176 | 12,121 | -13,055 | 0.01 | 0.00 | -0.00 | sell |
| FMR LLC | 16,944 | 2,600 | -14,344 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 15,749 | 0 | -15,749 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 17,796 | 0 | -17,796 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 36,197 | 17,797 | -18,400 | 0.00 | 0.00 | -0.00 | sell |
| Paloma Partners Management Co | 19,019 | 0 | -19,019 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 27,580 | 0 | -27,580 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,931 | 71,945 | -27,986 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 28,172 | 0 | -28,172 | 0.00 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 33,100 | 0 | -33,100 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 48,960 | 0 | -48,960 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 226,085 | 176,783 | -49,302 | 0.00 | 0.00 | +0.00 | sell |
| 683 Capital Management, LLC | 80,000 | 0 | -80,000 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 82,361 | 0 | -82,361 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 158,680 | 68,474 | -90,206 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 154,270 | 0 | -154,270 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 493,136 | 0 | -493,136 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 509,572 | 0 | -509,572 | 0.07 | 0.00 | -0.07 | sell |