| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STEMPOINT CAPITAL LP | 0 | 424,082 | +424,082 | 0.00 | 0.16 | +0.16 | buy |
| CITADEL ADVISORS LLC | 0 | 140,220 | +140,220 | 0.00 | 0.00 | +0.00 | buy |
| Peapod Lane Capital LLC | 242,210 | 303,585 | +61,375 | 0.45 | 0.52 | +0.06 | buy |
| Stonepine Capital Management, LLC | 0 | 35,253 | +35,253 | 0.00 | 0.05 | +0.05 | buy |
| VANGUARD GROUP INC | 1,315,285 | 1,342,907 | +27,622 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 26,206 | +26,206 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 61,366 | 83,660 | +22,294 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 19,780 | +19,780 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 372,334 | 381,754 | +9,420 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 35 | +35 | 0.00 | 0.00 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 4,166,000 | 4,166,000 | 0 | 0.20 | 0.19 | -0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 160 | 160 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QVT Financial LP | 4,615,709 | 4,615,709 | 0 | 1.15 | 0.92 | -0.22 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,000 | 3,700,000 | 0 | 0.26 | 0.21 | -0.05 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 3,410,402 | 3,410,402 | 0 | 8.90 | 6.70 | -2.21 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.09 | 0.07 | -0.02 | hold |
| Yu Fan | 2,070,000 | 2,070,000 | 0 | 5.29 | 5.12 | -0.17 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 386 | 386 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ally Bridge Group (NY) LLC | 817,939 | 817,939 | 0 | 1.27 | 1.30 | +0.03 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 100.00 | 100.00 | 0.00 | hold |
| SBI Securities Co., Ltd. | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 2,082,000 | 2,082,000 | 0 | 0.20 | 0.15 | -0.05 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,139,363 | 1,139,363 | 0 | 1.39 | 1.10 | -0.29 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 68,737 | 68,737 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 358 | 0 | -358 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 458,222 | 457,422 | -800 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 298,320 | 296,158 | -2,162 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,098 | 797 | -3,301 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 11,103 | 0 | -11,103 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 92,275 | 72,164 | -20,111 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 70,749 | 44,115 | -26,634 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 315,284 | 215,284 | -100,000 | 0.01 | 0.01 | -0.01 | sell |
| JANE STREET GROUP, LLC | 105,310 | 0 | -105,310 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 1,091,417 | 0 | -1,091,417 | 0.12 | 0.00 | -0.12 | sell |