| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| QVT Financial LP | 0 | 2,313,702 | +2,313,702 | 0.00 | 0.65 | +0.65 | buy |
| Ally Bridge Group (NY) LLC | 0 | 817,939 | +817,939 | 0.00 | 2.21 | +2.21 | buy |
| BML Capital Management, LLC | 2,000,000 | 2,100,000 | +100,000 | 2.42 | 4.12 | +1.69 | buy |
| CITADEL ADVISORS LLC | 0 | 62,035 | +62,035 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,917 | 68,555 | +51,638 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 31,600 | 61,686 | +30,086 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 68,474 | 91,151 | +22,677 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 93,300 | 115,400 | +22,100 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 208,748 | 217,294 | +8,546 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 1,009 | 6,589 | +5,580 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 242,888 | 243,890 | +1,002 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 197 | +197 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 765,992 | 765,992 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 26,400 | 26,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marquette Asset Management, LLC | 63,564 | 63,564 | 0 | 0.02 | 0.03 | +0.01 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 1,849,402 | 1,849,402 | 0 | 3.09 | 5.87 | +2.78 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.09 | 0.13 | +0.04 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 1,512 | 1,512 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Soleus Capital Management, L.P. | 333,227 | 333,227 | 0 | 0.06 | 0.08 | +0.02 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 4.89 | 7.77 | +2.88 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 (DIFC) Ltd | 77 | 77 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 35,595 | 35,595 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STATE STREET CORP | 68,737 | 68,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 81 | 75 | -6 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 14,495 | 14,484 | -11 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 25 | 0 | -25 | 0.00 | 0.00 | 0.00 | sell |
| FEDERATED HERMES, INC. | 4,823 | 4,724 | -99 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 41,700 | 41,600 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 12,121 | 11,609 | -512 | 0.00 | 0.01 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 2,339 | 558 | -1,781 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,793 | 0 | -1,793 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,591 | 13,245 | -2,346 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 2,600 | 0 | -2,600 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 176,783 | 173,998 | -2,785 | 0.00 | 0.00 | +0.00 | sell |
| Catalyst Funds Management Pty Ltd | 4,100 | 0 | -4,100 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 17,797 | 12,897 | -4,900 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 461,822 | 456,022 | -5,800 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 10,510 | 0 | -10,510 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 21,097 | 0 | -21,097 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 47,019 | 0 | -47,019 | 0.02 | 0.00 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,945 | 0 | -71,945 | 0.00 | 0.00 | -0.00 | sell |
| Acuitas Investments, LLC | 438,760 | 0 | -438,760 | 0.40 | 0.00 | -0.40 | sell |
| EcoR1 Capital, LLC | 1,845,253 | 345,253 | -1,500,000 | 0.13 | 0.04 | -0.09 | sell |