| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STEMPOINT CAPITAL LP | 424,082 | 1,458,807 | +1,034,725 | 0.16 | 0.61 | +0.44 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 309,865 | +309,865 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 260,259 | +260,259 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 1,342,907 | 1,590,117 | +247,210 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 110,083 | +110,083 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 77,593 | +77,593 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 68,737 | 145,537 | +76,800 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 72,348 | +72,348 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 67,959 | +67,959 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 381,754 | 425,440 | +43,686 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 42,400 | +42,400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 72,164 | 103,452 | +31,288 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 18,796 | +18,796 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 11,447 | +11,447 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 296,158 | 299,011 | +2,853 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,166,000 | 4,166,000 | 0 | 0.19 | 0.21 | +0.02 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215,284 | 215,284 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 160 | 160 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QVT Financial LP | 4,615,709 | 4,615,709 | 0 | 0.92 | 1.01 | +0.08 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,000 | 3,700,000 | 0 | 0.21 | 0.22 | +0.01 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 3,410,402 | 3,410,402 | 0 | 6.70 | 5.60 | -1.09 | hold |
| Avoro Capital Advisors LLC | 2,849,402 | 2,849,402 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Yu Fan | 2,070,000 | 2,070,000 | 0 | 5.12 | 5.43 | +0.31 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 386 | 386 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ally Bridge Group (NY) LLC | 817,939 | 817,939 | 0 | 1.30 | 3.14 | +1.84 | hold |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | 26,666 | 0 | 100.00 | 100.00 | 0.00 | hold |
| SBI Securities Co., Ltd. | 19 | 19 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 232 | 232 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Siren, L.L.C. | 2,082,000 | 2,082,000 | 0 | 0.15 | 0.15 | -0.00 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | 1,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,139,363 | 1,139,363 | 0 | 1.10 | 0.93 | -0.16 | hold |
| US BANCORP \DE\ | 3,333 | 3,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 35 | 0 | -35 | 0.00 | 0.00 | 0.00 | sell |
| Tower Research Capital LLC (TRC) | 797 | 0 | -797 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 26,206 | 24,634 | -1,572 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 19,780 | 15,704 | -4,076 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 44,115 | 28,641 | -15,474 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 457,422 | 440,722 | -16,700 | 0.00 | 0.00 | +0.00 | sell |
| Stonepine Capital Management, LLC | 35,253 | 0 | -35,253 | 0.05 | 0.00 | -0.05 | sell |
| CITADEL ADVISORS LLC | 140,220 | 98,950 | -41,270 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 83,660 | 0 | -83,660 | 0.00 | 0.00 | -0.00 | sell |
| Peapod Lane Capital LLC | 303,585 | 0 | -303,585 | 0.52 | 0.00 | -0.52 | sell |