| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALETHEA CAPITAL MANAGEMENT, LLC | 1,529,369 | 2,167,938 | +638,569 | 6.38 | 9.85 | +3.47 | buy |
| Rhenman & Partners Asset Management AB | 271,500 | 591,500 | +320,000 | 0.27 | 0.61 | +0.34 | buy |
| Hennion & Walsh Asset Management, Inc. | 335,212 | 568,845 | +233,633 | 0.09 | 0.18 | +0.09 | buy |
| NAN FUNG TRINITY (HK) Ltd | 1,064,880 | 1,174,880 | +110,000 | 0.95 | 1.27 | +0.32 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 17,316 | 49,513 | +32,197 | 0.02 | 0.09 | +0.07 | buy |
| SECTOR GAMMA AS | 411,810 | 433,012 | +21,202 | 0.79 | 1.03 | +0.24 | buy |
| NorthCrest Asset Manangement, LLC | 17,456 | 21,132 | +3,676 | 0.00 | 0.01 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 66,840 | 67,455 | +615 | 0.03 | 0.04 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 295,522 | 295,039 | -483 | 0.38 | 0.42 | +0.04 | sell |
| China Universal Asset Management Co., Ltd. | 15,442 | 14,128 | -1,314 | 0.01 | 0.01 | -0.00 | sell |
| Xcel Wealth Management, LLC | 95,393 | 90,983 | -4,410 | 0.22 | 0.24 | +0.02 | sell |
| Rangeley Capital, LLC | 101,220 | 94,000 | -7,220 | 0.80 | 0.94 | +0.14 | sell |
| 1492 Capital Management LLC | 486,123 | 467,153 | -18,970 | 1.50 | 1.51 | +0.01 | sell |
| ARMISTICE CAPITAL, LLC | 3,736,000 | 3,678,000 | -58,000 | 0.54 | 0.49 | -0.05 | sell |
| GREAT LAKES ADVISORS, LLC | 339,599 | 259,857 | -79,742 | 0.02 | 0.02 | -0.00 | sell |
| DRW Securities, LLC | 132,174 | 21,398 | -110,776 | 0.01 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 235,868 | 120,568 | -115,300 | 0.44 | 0.25 | -0.18 | sell |
| Prosight Management, LP | 3,356,700 | 2,021,964 | -1,334,736 | 4.48 | 3.82 | -0.65 | sell |