| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,946,230 | 7,069,627 | +123,397 | 4.57 | 6.36 | +1.79 | buy |
| EcoR1 Capital, LLC | 5,806,871 | 5,806,871 | 0 | 2.17 | 3.14 | +0.98 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,312,733 | 5,411,571 | +98,838 | 1.41 | 2.01 | +0.60 | buy |
| BVF INC/IL | 7,373,228 | 4,786,293 | -2,586,935 | 2.65 | 2.81 | +0.15 | sell |
| STATE STREET CORP | 2,921,810 | 4,199,954 | +1,278,144 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,037,691 | 4,065,903 | +28,212 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,980,000 | 3,850,000 | +870,000 | 0.59 | 0.96 | +0.37 | buy |
| Paradigm Biocapital Advisors LP | 1,262,828 | 3,135,387 | +1,872,559 | 0.85 | 2.35 | +1.50 | buy |
| Holocene Advisors, LP | 2,437,463 | 2,437,463 | 0 | 0.14 | 0.19 | +0.05 | hold |
| ARMISTICE CAPITAL, LLC | 2,224,000 | 2,048,000 | -176,000 | 0.85 | 1.16 | +0.31 | sell |
| Artal Group S.A. | 1,768,056 | 1,919,884 | +151,828 | 0.87 | 1.06 | +0.19 | buy |
| Foresite Capital Management IV, LLC | 1,849,947 | 1,849,947 | 0 | 13.44 | 19.94 | +6.49 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,656,009 | 1,707,274 | +51,265 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,353,665 | 1,575,246 | +221,581 | 0.01 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 1,248,062 | 1,525,000 | +276,938 | 1.57 | 2.18 | +0.61 | buy |
| TCG Crossover Management, LLC | 1,423,642 | 1,423,642 | 0 | 2.27 | 2.40 | +0.13 | hold |
| DIMENSIONAL FUND ADVISORS LP | 2,001,754 | 1,363,435 | -638,319 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,330,955 | 1,357,461 | +26,506 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 1,153,845 | 1,153,845 | 0 | 0.05 | 0.07 | +0.01 | hold |
| Prosight Management, LP | 950,000 | 960,000 | +10,000 | 5.48 | 5.70 | +0.21 | buy |
| GOLDMAN SACHS GROUP INC | 531,562 | 785,876 | +254,314 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 191,535 | 730,492 | +538,957 | 0.55 | 2.53 | +1.98 | buy |
| NORTHERN TRUST CORP | 709,820 | 694,346 | -15,474 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 541,417 | 651,417 | +110,000 | 0.05 | 0.09 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 703,287 | 610,826 | -92,461 | 1.88 | 2.11 | +0.23 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 579,987 | 598,724 | +18,737 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,683 | 594,879 | +530,196 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 1,667,321 | 501,940 | -1,165,381 | 1.34 | 0.63 | -0.71 | sell |
| MILLENNIUM MANAGEMENT LLC | 132,490 | 488,216 | +355,726 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 751,341 | 480,622 | -270,719 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 472,992 | 434,396 | -38,596 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 492,684 | 412,663 | -80,021 | 1.70 | 2.00 | +0.31 | sell |
| D. E. Shaw & Co., Inc. | 205,620 | 389,902 | +184,282 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 365,044 | +365,044 | 0.00 | 4.33 | +4.33 | buy |
| Verition Fund Management LLC | 465,593 | 361,820 | -103,773 | 0.07 | 0.07 | +0.01 | sell |
| Invesco Ltd. | 69,127 | 314,072 | +244,945 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 151,274 | 311,268 | +159,994 | 0.01 | 0.02 | +0.02 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 0.67 | +0.67 | buy |
| ALGERT GLOBAL LLC | 333,450 | 279,570 | -53,880 | 0.19 | 0.23 | +0.04 | sell |
| CITIGROUP INC | 68,233 | 271,896 | +203,663 | 0.00 | 0.01 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 350,445 | 259,606 | -90,839 | 5.81 | 4.50 | -1.32 | sell |
| Bank of New York Mellon Corp | 260,789 | 244,685 | -16,104 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 278,100 | 240,200 | -37,900 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 202,957 | 226,821 | +23,864 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 224,784 | 224,296 | -488 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 127,643 | 181,674 | +54,031 | 0.10 | 0.21 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 177,650 | +177,650 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 166,526 | +166,526 | 0.00 | 0.34 | +0.34 | buy |
| JANE STREET GROUP, LLC | 98,315 | 162,073 | +63,758 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 130,000 | 130,000 | 0 | 1.55 | 1.61 | +0.06 | hold |
| RHUMBLINE ADVISERS | 112,063 | 113,608 | +1,545 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 109,851 | +109,851 | 0.00 | 0.40 | +0.40 | buy |
| Cubist Systematic Strategies, LLC | 25,211 | 109,161 | +83,950 | 0.00 | 0.03 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,266 | 109,155 | +41,889 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 207,272 | 103,912 | -103,360 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 102,400 | 102,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.22 | +0.22 | buy |
| Squarepoint Ops LLC | 95,159 | 95,288 | +129 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 701,349 | 90,000 | -611,349 | 5.68 | 1.25 | -4.43 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 81,856 | 86,666 | +4,810 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 21,600 | 86,500 | +64,900 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 80,100 | 84,800 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 45,542 | 83,252 | +37,710 | 0.01 | 0.02 | +0.01 | buy |
| Simplify Asset Management Inc. | 80,000 | 80,000 | 0 | 0.18 | 0.16 | -0.01 | hold |
| 1492 Capital Management LLC | 101,500 | 72,858 | -28,642 | 0.83 | 0.87 | +0.04 | sell |
| Aaron Wealth Advisors LLC | 54,946 | 68,475 | +13,529 | 0.13 | 0.21 | +0.08 | buy |
| FMR LLC | 64,474 | 64,673 | +199 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 61,109 | +61,109 | 0.00 | 0.74 | +0.74 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 93,153 | 59,577 | -33,576 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 0 | 58,967 | +58,967 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,887 | 53,857 | -4,030 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 53,738 | +53,738 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 50,479 | 53,700 | +3,221 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 53,585 | 52,917 | -668 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 91,801 | 49,496 | -42,305 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 25,588 | 48,682 | +23,094 | 0.02 | 0.04 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 48,200 | +48,200 | 0.00 | 0.02 | +0.02 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 46,789 | +46,789 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 0 | 45,593 | +45,593 | 0.00 | 0.03 | +0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 36,311 | 40,970 | +4,659 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 39,478 | +39,478 | 0.00 | 0.21 | +0.21 | buy |
| MetLife Investment Management, LLC | 37,332 | 37,332 | 0 | 0.00 | 0.01 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,845 | 36,560 | +8,715 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 88,889 | 35,548 | -53,341 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 35,074 | 34,775 | -299 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 56,363 | 34,372 | -21,991 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 354,279 | 33,241 | -321,038 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,709 | 31,154 | -555 | 0.00 | 0.00 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 30,891 | +30,891 | 0.00 | 0.09 | +0.09 | buy |
| BIT Capital GmbH | 0 | 30,184 | +30,184 | 0.00 | 0.06 | +0.06 | buy |
| Cinctive Capital Management LP | 89,131 | 29,543 | -59,588 | 0.09 | 0.03 | -0.06 | sell |
| WELLS FARGO & COMPANY/MN | 23,591 | 26,247 | +2,656 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 25,000 | 26,000 | +1,000 | 0.15 | 0.19 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 25,261 | 25,263 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 23,754 | +23,754 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 7,545 | 23,746 | +16,201 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 29,159 | 23,424 | -5,735 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 29,990 | 23,233 | -6,757 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 22,684 | 22,514 | -170 | 0.00 | 0.00 | -0.00 | sell |