| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,262,828 | 3,135,387 | +1,872,559 | 0.85 | 2.35 | +1.50 | buy |
| STATE STREET CORP | 2,921,810 | 4,199,954 | +1,278,144 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,980,000 | 3,850,000 | +870,000 | 0.59 | 0.96 | +0.37 | buy |
| Affinity Asset Advisors, LLC | 191,535 | 730,492 | +538,957 | 0.55 | 2.53 | +1.98 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,683 | 594,879 | +530,196 | 0.00 | 0.02 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 0 | 365,044 | +365,044 | 0.00 | 4.33 | +4.33 | buy |
| MILLENNIUM MANAGEMENT LLC | 132,490 | 488,216 | +355,726 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 0.67 | +0.67 | buy |
| Commodore Capital LP | 1,248,062 | 1,525,000 | +276,938 | 1.57 | 2.18 | +0.61 | buy |
| GOLDMAN SACHS GROUP INC | 531,562 | 785,876 | +254,314 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 69,127 | 314,072 | +244,945 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,353,665 | 1,575,246 | +221,581 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 68,233 | 271,896 | +203,663 | 0.00 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 205,620 | 389,902 | +184,282 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 177,650 | +177,650 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 166,526 | +166,526 | 0.00 | 0.34 | +0.34 | buy |
| Rafferty Asset Management, LLC | 151,274 | 311,268 | +159,994 | 0.01 | 0.02 | +0.02 | buy |
| Artal Group S.A. | 1,768,056 | 1,919,884 | +151,828 | 0.87 | 1.06 | +0.19 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,946,230 | 7,069,627 | +123,397 | 4.57 | 6.36 | +1.79 | buy |
| Candriam S.C.A. | 541,417 | 651,417 | +110,000 | 0.05 | 0.09 | +0.04 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 109,851 | +109,851 | 0.00 | 0.40 | +0.40 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.22 | +0.22 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,312,733 | 5,411,571 | +98,838 | 1.41 | 2.01 | +0.60 | buy |
| Cubist Systematic Strategies, LLC | 25,211 | 109,161 | +83,950 | 0.00 | 0.03 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 21,600 | 86,500 | +64,900 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 98,315 | 162,073 | +63,758 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 61,109 | +61,109 | 0.00 | 0.74 | +0.74 | buy |
| Lighthouse Investment Partners, LLC | 0 | 58,967 | +58,967 | 0.00 | 0.06 | +0.06 | buy |
| Hennion & Walsh Asset Management, Inc. | 127,643 | 181,674 | +54,031 | 0.10 | 0.21 | +0.10 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 53,738 | +53,738 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,656,009 | 1,707,274 | +51,265 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 48,200 | +48,200 | 0.00 | 0.02 | +0.02 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 46,789 | +46,789 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 0 | 45,593 | +45,593 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,266 | 109,155 | +41,889 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 39,478 | +39,478 | 0.00 | 0.21 | +0.21 | buy |
| Walleye Capital LLC | 45,542 | 83,252 | +37,710 | 0.01 | 0.02 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 30,891 | +30,891 | 0.00 | 0.09 | +0.09 | buy |
| BIT Capital GmbH | 0 | 30,184 | +30,184 | 0.00 | 0.06 | +0.06 | buy |
| VANGUARD GROUP INC | 4,037,691 | 4,065,903 | +28,212 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,330,955 | 1,357,461 | +26,506 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 202,957 | 226,821 | +23,864 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 23,754 | +23,754 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 25,588 | 48,682 | +23,094 | 0.02 | 0.04 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 579,987 | 598,724 | +18,737 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 18,079 | +18,079 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 17,768 | +17,768 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 17,337 | +17,337 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,545 | 23,746 | +16,201 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 14,710 | +14,710 | 0.00 | 0.02 | +0.02 | buy |
| Aaron Wealth Advisors LLC | 54,946 | 68,475 | +13,529 | 0.13 | 0.21 | +0.08 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 13,339 | +13,339 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 0 | 12,381 | +12,381 | 0.00 | 0.01 | +0.01 | buy |
| Entropy Technologies, LP | 0 | 10,215 | +10,215 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 0 | 10,172 | +10,172 | 0.00 | 0.01 | +0.01 | buy |
| Prosight Management, LP | 950,000 | 960,000 | +10,000 | 5.48 | 5.70 | +0.21 | buy |
| Walleye Trading LLC | 0 | 9,688 | +9,688 | 0.00 | 0.00 | +0.00 | buy |
| SAXON INTERESTS, INC. | 0 | 9,420 | +9,420 | 0.00 | 0.10 | +0.10 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,845 | 36,560 | +8,715 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,590 | 15,617 | +7,027 | 0.02 | 0.04 | +0.02 | buy |
| US BANCORP \DE\ | 2,097 | 8,636 | +6,539 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 6,300 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,174 | +5,174 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 81,856 | 86,666 | +4,810 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 80,100 | 84,800 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 36,311 | 40,970 | +4,659 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 50,479 | 53,700 | +3,221 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,208 | 20,148 | +2,940 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,591 | 26,247 | +2,656 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 233 | 2,125 | +1,892 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 16,426 | 18,014 | +1,588 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 112,063 | 113,608 | +1,545 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,451 | +1,451 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 25,000 | 26,000 | +1,000 | 0.15 | 0.19 | +0.04 | buy |
| Rise Advisors, LLC | 0 | 531 | +531 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 64,474 | 64,673 | +199 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 95,159 | 95,288 | +129 | 0.01 | 0.01 | +0.00 | buy |
| COMERICA BANK | 138 | 221 | +83 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 990 | 1,060 | +70 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,690 | 1,759 | +69 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 495 | 551 | +56 | 0.00 | 0.00 | -0.00 | buy |
| Main Street Group, LTD | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 4 | +4 | 0.00 | 0.00 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 25,261 | 25,263 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,268 | 6,268 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 14,900 | 14,900 | 0 | 0.11 | 0.06 | -0.05 | hold |
| Ameritas Investment Partners, Inc. | 7,304 | 7,304 | 0 | 0.00 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 227 | 227 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 37,332 | 37,332 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Assenagon Asset Management S.A. | 1,153,845 | 1,153,845 | 0 | 0.05 | 0.07 | +0.01 | hold |
| Allworth Financial LP | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 102,400 | 102,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 5,806,871 | 5,806,871 | 0 | 2.17 | 3.14 | +0.98 | hold |
| Holocene Advisors, LP | 2,437,463 | 2,437,463 | 0 | 0.14 | 0.19 | +0.05 | hold |