| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,262,828 | 3,135,387 | +1,872,559 | 0.85 | 2.35 | +1.50 | buy |
| Avoro Capital Advisors LLC | 2,980,000 | 3,850,000 | +870,000 | 0.59 | 0.96 | +0.37 | buy |
| Affinity Asset Advisors, LLC | 191,535 | 730,492 | +538,957 | 0.55 | 2.53 | +1.98 | buy |
| Commodore Capital LP | 1,248,062 | 1,525,000 | +276,938 | 1.57 | 2.18 | +0.61 | buy |
| Rafferty Asset Management, LLC | 151,274 | 311,268 | +159,994 | 0.01 | 0.02 | +0.02 | buy |
| Artal Group S.A. | 1,768,056 | 1,919,884 | +151,828 | 0.85 | 1.04 | +0.20 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,946,230 | 7,069,627 | +123,397 | 4.52 | 5.60 | +1.08 | buy |
| Candriam S.C.A. | 541,417 | 651,417 | +110,000 | 0.05 | 0.09 | +0.04 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,312,733 | 5,411,571 | +98,838 | 1.41 | 2.01 | +0.60 | buy |
| Hennion & Walsh Asset Management, Inc. | 127,643 | 181,674 | +54,031 | 0.10 | 0.21 | +0.10 | buy |
| ALGERT GLOBAL LLC | 333,450 | 279,570 | +53,880 | 0.19 | 0.23 | 0.00 | sell |
| PROFUND ADVISORS LLC | 25,588 | 48,682 | +23,094 | 0.02 | 0.04 | 0.00 | buy |
| Aaron Wealth Advisors LLC | 54,946 | 68,475 | +13,529 | 0.13 | 0.21 | +0.08 | buy |
| Prosight Management, LP | 950,000 | 960,000 | +10,000 | 5.48 | 5.70 | +0.21 | buy |
| China Universal Asset Management Co., Ltd. | 8,590 | 15,617 | +7,027 | 0.02 | 0.04 | +0.02 | buy |
| ALPS ADVISORS INC | 50,479 | 53,700 | +3,221 | 0.01 | 0.01 | +0.00 | buy |
| MYDA Advisors LLC | 25,000 | 26,000 | +1,000 | 0.12 | 0.16 | +0.04 | buy |
| VIRTUS ADVISERS, LLC | 7,747 | 7,254 | -493 | 0.07 | 0.08 | +0.01 | sell |
| 1492 Capital Management LLC | 101,500 | 72,858 | -28,642 | 0.83 | 0.87 | +0.04 | sell |
| Cinctive Capital Management LP | 89,131 | 29,543 | -59,588 | 0.09 | 0.03 | -0.06 | sell |
| DAFNA Capital Management LLC | 492,684 | 412,663 | -80,021 | 1.70 | 2.00 | +0.31 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 350,445 | 259,606 | -90,839 | 5.81 | 4.50 | -1.32 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 703,287 | 610,826 | -92,461 | 1.63 | 1.83 | +0.20 | sell |
| ARMISTICE CAPITAL, LLC | 2,224,000 | 2,048,000 | -176,000 | 0.44 | 0.58 | +0.14 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 701,349 | 90,000 | -611,349 | 5.68 | 1.25 | -4.43 | sell |
| Sofinnova Investments, Inc. | 1,667,321 | 501,940 | -1,165,381 | 1.34 | 0.60 | -0.74 | sell |
| BVF INC/IL | 7,373,228 | 4,786,293 | -2,586,935 | 2.65 | 2.81 | +0.15 | sell |