| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,567,469 | 7,754,129 | +5,186,660 | 0.76 | 2.09 | +1.33 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,076,448 | 7,439,259 | +2,362,811 | 1.64 | 1.99 | +0.35 | buy |
| Sofinnova Investments, Inc. | 0 | 791,667 | +791,667 | 0.00 | 0.39 | +0.39 | buy |
| ARMISTICE CAPITAL, LLC | 5,800,000 | 6,572,000 | +772,000 | 1.17 | 1.16 | -0.02 | buy |
| Prosight Management, LP | 1,325,000 | 2,078,315 | +753,315 | 3.23 | 4.51 | +1.27 | buy |
| AQR CAPITAL MANAGEMENT LLC | 149,728 | 760,332 | +610,604 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 581,369 | +581,369 | 0.00 | 0.80 | +0.80 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 977,920 | 1,544,113 | +566,193 | 0.03 | 0.04 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 330,421 | +330,421 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 7,934,104 | 8,177,646 | +243,542 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 160,317 | +160,317 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 325,220 | 477,603 | +152,383 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 18,705 | 156,064 | +137,359 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,818,898 | 4,948,235 | +129,337 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 50,949 | 174,559 | +123,610 | 0.01 | 0.04 | +0.02 | buy |
| Trexquant Investment LP | 566,945 | 685,970 | +119,025 | 0.06 | 0.05 | -0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 558,442 | 659,177 | +100,735 | 4.16 | 3.25 | -0.92 | buy |
| Rosalind Advisors, Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.32 | +0.32 | buy |
| IEQ CAPITAL, LLC | 0 | 97,931 | +97,931 | 0.00 | 0.01 | +0.01 | buy |
| 1492 Capital Management LLC | 342,598 | 429,746 | +87,148 | 1.42 | 1.53 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,514 | 171,448 | +86,934 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 883,703 | 958,492 | +74,789 | 0.18 | 0.16 | -0.02 | buy |
| JENNISON ASSOCIATES LLC | 71,497 | 138,532 | +67,035 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,115,741 | 1,173,125 | +57,384 | 0.02 | 0.01 | -0.00 | buy |
| Savant Capital, LLC | 0 | 50,524 | +50,524 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 0 | 49,529 | +49,529 | 0.00 | 0.10 | +0.10 | buy |
| Russell Investments Group, Ltd. | 298,662 | 338,859 | +40,197 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 40,024 | +40,024 | 0.00 | 0.12 | +0.12 | buy |
| AlphaQuest LLC | 20,331 | 58,772 | +38,441 | 0.02 | 0.04 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 242,200 | 278,600 | +36,400 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 34,166 | 67,300 | +33,134 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 31,856 | +31,856 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 125,914 | 156,185 | +30,271 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 67,238 | 97,216 | +29,978 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,538,592 | 1,564,866 | +26,274 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 0 | 26,103 | +26,103 | 0.00 | 0.07 | +0.07 | buy |
| CWM, LLC | 2,856 | 28,353 | +25,497 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 25,346 | +25,346 | 0.00 | 0.08 | +0.08 | buy |
| ADAR1 Capital Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.03 | +0.03 | buy |
| Teza Capital Management LLC | 0 | 24,602 | +24,602 | 0.00 | 0.07 | +0.07 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 23,989 | +23,989 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 20,669 | 44,455 | +23,786 | 0.02 | 0.02 | -0.00 | buy |
| SYON CAPITAL LLC | 0 | 23,281 | +23,281 | 0.00 | 0.01 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 22,300 | +22,300 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 21,133 | +21,133 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,782,044 | 1,802,559 | +20,515 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 131,718 | 152,132 | +20,414 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Grove Partners LP | 0 | 19,682 | +19,682 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 22,104 | 39,627 | +17,523 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 16,942 | +16,942 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 664,928 | 681,630 | +16,702 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 16,614 | +16,614 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 16,424 | +16,424 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 448,368 | 463,368 | +15,000 | 0.99 | 0.87 | -0.13 | buy |
| SIMPLEX TRADING, LLC | 0 | 14,863 | +14,863 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 11,344 | 25,300 | +13,956 | 0.06 | 0.55 | +0.50 | buy |
| Assenagon Asset Management S.A. | 905,184 | 919,079 | +13,895 | 0.01 | 0.01 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 12,768 | +12,768 | 0.00 | 0.00 | +0.00 | buy |
| Flower City Capital | 0 | 12,000 | +12,000 | 0.00 | 0.05 | +0.05 | buy |
| Magnetar Financial LLC | 0 | 11,984 | +11,984 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 11,751 | +11,751 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 43,085 | 54,491 | +11,406 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 0 | 10,063 | +10,063 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 8,024 | 17,474 | +9,450 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 51,167 | 60,118 | +8,951 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 7,347 | +7,347 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 26,630 | 32,784 | +6,154 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 99,991 | 105,206 | +5,215 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,070 | 31,718 | +3,648 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,031 | 50,008 | +2,977 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 10,301 | 12,252 | +1,951 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 1,686 | +1,686 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,989 | 36,366 | +1,377 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 9 | 1,252 | +1,243 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 964 | +964 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 66,706 | 67,563 | +857 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 990 | 1,796 | +806 | 0.00 | 0.00 | +0.00 | buy |
| NorthCrest Asset Manangement, LLC | 10,512 | 11,300 | +788 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,630 | 2,344 | +714 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 12,490 | 13,028 | +538 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 7 | 397 | +390 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,633 | 1,991 | +358 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 188 | 509 | +321 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 36,050 | 36,262 | +212 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 211 | +211 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| Golden State Wealth Management, LLC | 0 | 129 | +129 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,591 | 2,702 | +111 | 0.00 | 0.00 | -0.00 | buy |
| Aaron Wealth Advisors LLC | 65,685 | 65,786 | +101 | 0.07 | 0.05 | -0.02 | buy |
| ROTHSCHILD INVESTMENT LLC | 85 | 175 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 15 | 104 | +89 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,320 | 13,383 | +63 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 6 | 14 | +8 | 0.00 | 0.00 | 0.00 | buy |
| CoreCap Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 14,900 | 14,900 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,304 | 7,304 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,923 | 44,923 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 60,847 | 60,847 | 0 | 0.00 | 0.00 | -0.00 | hold |