| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,567,469 | 7,754,129 | +5,186,660 | 0.76 | 2.09 | +1.33 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,076,448 | 7,439,259 | +2,362,811 | 1.51 | 1.82 | +0.32 | buy |
| ARMISTICE CAPITAL, LLC | 5,800,000 | 6,572,000 | +772,000 | 0.69 | 0.65 | -0.04 | buy |
| Prosight Management, LP | 1,325,000 | 2,078,315 | +753,315 | 3.19 | 4.51 | +1.32 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 558,442 | 659,177 | +100,735 | 4.16 | 3.25 | -0.92 | buy |
| 1492 Capital Management LLC | 342,598 | 429,746 | +87,148 | 1.42 | 1.53 | +0.11 | buy |
| ALGERT GLOBAL LLC | 883,703 | 958,492 | +74,789 | 0.18 | 0.16 | 0.00 | buy |
| JENNISON ASSOCIATES LLC | 71,497 | 138,532 | +67,035 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 297,234 | 240,746 | +56,488 | 0.03 | 0.02 | 0.00 | sell |
| AlphaQuest LLC | 20,331 | 58,772 | +38,441 | 0.02 | 0.05 | 0.00 | buy |
| DAFNA Capital Management LLC | 448,368 | 463,368 | +15,000 | 0.99 | 0.87 | -0.13 | buy |
| Corton Capital Inc. | 11,344 | 25,300 | +13,956 | 0.06 | 0.55 | +0.50 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 49,371 | 37,944 | +11,427 | 0.02 | 0.01 | 0.00 | sell |
| E Fund Management Co., Ltd. | 10,301 | 12,252 | +1,951 | 0.00 | 0.00 | -0.00 | buy |
| NorthCrest Asset Manangement, LLC | 10,512 | 11,300 | +788 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,633 | 1,991 | +358 | 0.00 | 0.00 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 65,685 | 65,786 | +101 | 0.07 | 0.05 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 16,489 | 16,198 | -291 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 28,358 | 27,324 | -1,034 | 0.01 | 0.01 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 122,915 | 119,816 | -3,099 | 0.05 | 0.04 | -0.01 | sell |
| Nebula Research & Development LLC | 63,866 | 57,424 | -6,442 | 0.07 | 0.04 | -0.03 | sell |
| Rafferty Asset Management, LLC | 145,614 | 131,098 | -14,516 | 0.00 | 0.00 | -0.00 | sell |
| Voss Capital, LP | 275,000 | 250,000 | -25,000 | 0.18 | 0.13 | -0.05 | sell |
| Woodline Partners LP | 172,704 | 145,704 | -27,000 | 0.01 | 0.01 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 314,526 | 195,000 | -119,526 | 0.28 | 0.15 | -0.13 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 610,087 | 343,522 | -266,565 | 0.96 | 0.52 | -0.44 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 4,451,041 | 4,004,610 | -446,431 | 0.52 | 0.44 | -0.07 | sell |
| Foresite Capital Management IV, LLC | 1,726,882 | 1,111,882 | -615,000 | 13.83 | 6.61 | -7.22 | sell |
| EcoR1 Capital, LLC | 3,557,269 | 2,640,298 | -916,971 | 1.17 | 1.03 | -0.14 | sell |