| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 9,010,793 | 9,637,531 | +626,738 | 0.00 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,575,422 | 8,575,422 | 0 | 2.22 | 1.89 | -0.33 | hold |
| BVF INC/IL | 8,617,162 | 8,445,769 | -171,393 | 3.01 | 2.19 | -0.83 | sell |
| STATE STREET CORP | 4,931,090 | 4,511,891 | -419,199 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 4,936,000 | 3,736,000 | -1,200,000 | 1.26 | 1.00 | -0.25 | sell |
| Prosight Management, LP | 2,529,600 | 3,356,700 | +827,100 | 5.43 | 4.48 | -0.96 | buy |
| Deep Track Capital, LP | 0 | 2,643,542 | +2,643,542 | 0.00 | 0.44 | +0.44 | buy |
| AQR CAPITAL MANAGEMENT LLC | 3,062,212 | 2,124,480 | -937,732 | 0.02 | 0.01 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,028,618 | 2,034,276 | +5,658 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 1,333,523 | 1,636,733 | +303,210 | 0.02 | 0.02 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,830,566 | 1,582,568 | -247,998 | 0.03 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,584,399 | 1,565,143 | -19,256 | 0.01 | 0.01 | -0.00 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 1,422,682 | 1,529,369 | +106,687 | 7.18 | 6.68 | -0.50 | buy |
| GOLDMAN SACHS GROUP INC | 1,837,264 | 1,433,471 | -403,793 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,077,818 | 1,425,945 | +348,127 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 842,128 | 1,230,131 | +388,003 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,389,828 | 1,163,977 | -225,851 | 0.00 | 0.00 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 964,880 | 1,064,880 | +100,000 | 0.79 | 0.95 | +0.16 | buy |
| UBS Group AG | 1,060,025 | 1,040,233 | -19,792 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 452,245 | 857,474 | +405,229 | 0.61 | 0.61 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 618,571 | 800,597 | +182,026 | 0.02 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 723,217 | 756,273 | +33,056 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 710,882 | 690,817 | -20,065 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 471,993 | 675,305 | +203,312 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 477,145 | 663,350 | +186,205 | 0.01 | 0.01 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,022,333 | 602,231 | -1,420,102 | 0.08 | 0.02 | -0.06 | sell |
| Trexquant Investment LP | 227,382 | 528,704 | +301,322 | 0.02 | 0.03 | +0.01 | buy |
| Jump Financial, LLC | 422,443 | 505,452 | +83,009 | 0.06 | 0.06 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,117,042 | 486,570 | -630,472 | 0.01 | 0.00 | -0.00 | sell |
| 1492 Capital Management LLC | 452,638 | 486,123 | +33,485 | 1.80 | 1.50 | -0.30 | buy |
| Man Group plc | 241,539 | 475,027 | +233,488 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 98,029 | 449,024 | +350,995 | 0.00 | 0.01 | +0.01 | buy |
| SECTOR GAMMA AS | 455,841 | 411,810 | -44,031 | 1.08 | 0.79 | -0.29 | sell |
| CITADEL ADVISORS LLC | 390,672 | 368,825 | -21,847 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 886,579 | 365,118 | -521,461 | 0.02 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 471,794 | 357,955 | -113,839 | 0.01 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 392,817 | 343,891 | -48,926 | 0.06 | 0.04 | -0.02 | sell |
| Assenagon Asset Management S.A. | 1,145,016 | 339,712 | -805,304 | 0.02 | 0.00 | -0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 390,231 | 339,599 | -50,632 | 0.03 | 0.02 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 294,805 | 335,212 | +40,407 | 0.11 | 0.09 | -0.01 | buy |
| SEI INVESTMENTS CO | 183,448 | 319,266 | +135,818 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 306,602 | 317,652 | +11,050 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 295,522 | 295,522 | 0 | 0.64 | 0.41 | -0.23 | hold |
| IEQ CAPITAL, LLC | 398,455 | 281,904 | -116,551 | 0.01 | 0.01 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 872,000 | 271,500 | -600,500 | 0.85 | 0.27 | -0.57 | sell |
| Bank of New York Mellon Corp | 258,427 | 254,325 | -4,102 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 235,868 | 235,868 | 0 | 0.57 | 0.44 | -0.13 | hold |
| ExodusPoint Capital Management, LP | 24,553 | 229,728 | +205,175 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 346,676 | 226,160 | -120,516 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 3,742 | 221,205 | +217,463 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 209,370 | 206,771 | -2,599 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 198,785 | 201,696 | +2,911 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 25,363 | 185,118 | +159,755 | 0.01 | 0.03 | +0.02 | buy |
| Janney Montgomery Scott LLC | 41,200 | 158,850 | +117,650 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 394,605 | 154,393 | -240,212 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 151,070 | 151,863 | +793 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 145,704 | 145,704 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Swiss National Bank | 145,600 | 145,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 38,043 | 137,800 | +99,757 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 187,391 | 134,152 | -53,239 | 0.01 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 20,025 | 132,174 | +112,149 | 0.02 | 0.06 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 106,889 | 124,153 | +17,264 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 156,544 | 123,686 | -32,858 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 117,694 | +117,694 | 0.00 | 0.02 | +0.02 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 115,307 | 116,042 | +735 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 104,447 | 104,815 | +368 | 0.00 | 0.00 | -0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 133,357 | 102,157 | -31,200 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 102,900 | 101,220 | -1,680 | 0.92 | 0.89 | -0.03 | sell |
| Cerity Partners LLC | 134,311 | 101,022 | -33,289 | 0.00 | 0.00 | -0.00 | sell |
| Rosalind Advisors, Inc. | 100,000 | 100,000 | 0 | 0.38 | 0.33 | -0.05 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,513 | 98,592 | -17,921 | 0.00 | 0.00 | -0.00 | sell |
| Xcel Wealth Management, LLC | 118,846 | 95,393 | -23,453 | 0.32 | 0.22 | -0.10 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,051 | 95,317 | +23,266 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 125,920 | 92,811 | -33,109 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 38,805 | 89,303 | +50,498 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 52,003 | 89,032 | +37,029 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 80,809 | 88,739 | +7,930 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 64,675 | 88,603 | +23,928 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 44,843 | 84,575 | +39,732 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 160,031 | 83,533 | -76,498 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 66,870 | 82,610 | +15,740 | 0.19 | 0.19 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 78,215 | +78,215 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 71,447 | 71,906 | +459 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 78,258 | 71,660 | -6,598 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 54,110 | 71,480 | +17,370 | 0.45 | 0.50 | +0.05 | buy |
| Aaron Wealth Advisors LLC | 67,142 | 66,840 | -302 | 0.04 | 0.03 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 75,702 | 63,523 | -12,179 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 69,124 | 59,918 | -9,206 | 0.02 | 0.02 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,727 | 58,094 | +12,367 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 45,610 | 55,530 | +9,920 | 0.04 | 0.04 | -0.00 | buy |
| CITIGROUP INC | 29,412 | 53,995 | +24,583 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 39,209 | 52,767 | +13,558 | 0.19 | 0.26 | +0.07 | buy |
| Weiss Asset Management LP | 0 | 52,687 | +52,687 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 40,101 | 52,572 | +12,471 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 0 | 52,321 | +52,321 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 151,715 | 49,816 | -101,899 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 48,366 | 47,335 | -1,031 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,363 | 46,363 | 0 | 0.00 | 0.00 | -0.00 | hold |