| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 3,135,387 | 4,539,381 | +1,403,994 | 2.35 | 3.58 | +1.22 | buy |
| Sofinnova Investments, Inc. | 501,940 | 825,243 | +323,303 | 0.60 | 0.88 | +0.29 | buy |
| ARMISTICE CAPITAL, LLC | 2,048,000 | 2,350,000 | +302,000 | 0.58 | 0.61 | +0.03 | buy |
| Candriam S.C.A. | 651,417 | 906,482 | +255,065 | 0.09 | 0.11 | +0.02 | buy |
| Holocene Advisors, LP | 2,437,463 | 2,689,456 | +251,993 | 0.19 | 0.23 | +0.04 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 90,000 | 163,000 | +73,000 | 1.25 | 2.83 | +1.58 | buy |
| Commodore Capital LP | 1,525,000 | 1,593,350 | +68,350 | 2.18 | 2.24 | +0.06 | buy |
| PROFUND ADVISORS LLC | 48,682 | 23,567 | +25,115 | 0.04 | 0.02 | 0.00 | sell |
| ALGERT GLOBAL LLC | 279,570 | 260,783 | +18,787 | 0.23 | 0.18 | 0.00 | sell |
| Artia Global Partners LP | 39,478 | 57,178 | +17,700 | 0.21 | 0.30 | +0.10 | buy |
| DAFNA Capital Management LLC | 412,663 | 423,500 | +10,837 | 2.00 | 2.08 | +0.08 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,891 | 38,790 | +7,899 | 0.09 | 0.06 | -0.03 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 259,606 | 265,906 | +6,300 | 4.50 | 4.15 | -0.34 | buy |
| ALPS ADVISORS INC | 53,700 | 59,403 | +5,703 | 0.01 | 0.01 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 68,475 | 70,148 | +1,673 | 0.21 | 0.20 | -0.01 | buy |
| 1492 Capital Management LLC | 72,858 | 72,738 | -120 | 0.87 | 0.85 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 7,254 | 4,197 | -3,057 | 0.08 | 0.04 | -0.04 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 46,789 | 41,874 | -4,915 | 0.04 | 0.03 | -0.01 | sell |
| MYDA Advisors LLC | 26,000 | 20,000 | -6,000 | 0.16 | 0.09 | -0.07 | sell |
| China Universal Asset Management Co., Ltd. | 15,617 | 8,951 | -6,666 | 0.04 | 0.03 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 109,851 | 102,917 | -6,934 | 0.40 | 0.41 | +0.01 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 61,109 | 38,181 | -22,928 | 0.74 | 0.47 | -0.27 | sell |
| Hennion & Walsh Asset Management, Inc. | 181,674 | 127,619 | -54,055 | 0.21 | 0.13 | -0.07 | sell |
| Ally Bridge Group (NY) LLC | 365,044 | 306,762 | -58,282 | 4.33 | 3.76 | -0.57 | sell |
| Affinity Asset Advisors, LLC | 730,492 | 650,000 | -80,492 | 1.93 | 1.54 | -0.39 | sell |
| Artal Group S.A. | 1,919,884 | 1,819,884 | -100,000 | 1.04 | 0.96 | -0.09 | sell |
| Rafferty Asset Management, LLC | 311,268 | 124,585 | -186,683 | 0.02 | 0.01 | -0.02 | sell |
| Avoro Capital Advisors LLC | 3,850,000 | 3,541,505 | -308,495 | 0.96 | 0.97 | +0.01 | sell |
| Prosight Management, LP | 960,000 | 629,900 | -330,100 | 5.70 | 3.88 | -1.82 | sell |
| BVF INC/IL | 4,786,293 | 4,082,037 | -704,256 | 2.81 | 2.36 | -0.45 | sell |