| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 3,135,387 | 4,539,381 | +1,403,994 | 2.35 | 3.58 | +1.22 | buy |
| CITADEL ADVISORS LLC | 18,447 | 1,013,143 | +994,696 | 0.00 | 0.02 | +0.02 | buy |
| Assenagon Asset Management S.A. | 1,153,845 | 1,731,577 | +577,732 | 0.07 | 0.09 | +0.02 | buy |
| Deep Track Capital, LP | 0 | 384,756 | +384,756 | 0.00 | 0.24 | +0.24 | buy |
| Sofinnova Investments, Inc. | 501,940 | 825,243 | +323,303 | 0.63 | 1.07 | +0.44 | buy |
| ARMISTICE CAPITAL, LLC | 2,048,000 | 2,350,000 | +302,000 | 1.16 | 1.27 | +0.10 | buy |
| Candriam S.C.A. | 651,417 | 906,482 | +255,065 | 0.09 | 0.11 | +0.02 | buy |
| Holocene Advisors, LP | 2,437,463 | 2,689,456 | +251,993 | 0.19 | 0.23 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 182,557 | +182,557 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 143,207 | +143,207 | 0.00 | 0.03 | +0.03 | buy |
| Exome Asset Management LLC | 0 | 131,742 | +131,742 | 0.00 | 2.42 | +2.42 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.20 | +0.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 177,650 | 272,274 | +94,624 | 0.01 | 0.01 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 90,000 | 163,000 | +73,000 | 1.25 | 2.83 | +1.58 | buy |
| Eversept Partners, LP | 0 | 72,317 | +72,317 | 0.00 | 0.11 | +0.11 | buy |
| Commodore Capital LP | 1,525,000 | 1,593,350 | +68,350 | 2.18 | 2.24 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 23,233 | 81,655 | +58,422 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 23,424 | 77,475 | +54,051 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 785,876 | 831,885 | +46,009 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 43,702 | +43,702 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 86,666 | 125,104 | +38,438 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 36,242 | +36,242 | 0.00 | 0.94 | +0.94 | buy |
| Trexquant Investment LP | 18,706 | 54,064 | +35,358 | 0.01 | 0.02 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 32,721 | +32,721 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,707,274 | 1,738,974 | +31,700 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 86,500 | 114,700 | +28,200 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 59,577 | 85,892 | +26,315 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 26,267 | +26,267 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 24,340 | +24,340 | 0.00 | 0.09 | +0.09 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 23,700 | +23,700 | 0.00 | 0.04 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 21,933 | +21,933 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,200 | 21,700 | +20,500 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 39,478 | 57,178 | +17,700 | 0.21 | 0.30 | +0.10 | buy |
| HighVista Strategies LLC | 0 | 16,764 | +16,764 | 0.00 | 0.13 | +0.13 | buy |
| Tower Research Capital LLC (TRC) | 1,139 | 16,090 | +14,951 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 13,517 | +13,517 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 598,724 | 610,846 | +12,122 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,268 | 17,836 | +11,568 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 244,685 | 255,897 | +11,212 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 412,663 | 423,500 | +10,837 | 2.00 | 2.08 | +0.08 | buy |
| Allianz Asset Management GmbH | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 34,372 | 44,849 | +10,477 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 10,000 | +10,000 | 0.00 | 0.08 | +0.08 | buy |
| Quarry LP | 0 | 9,500 | +9,500 | 0.00 | 0.08 | +0.08 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,891 | 38,790 | +7,899 | 0.09 | 0.06 | -0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 7,070 | +7,070 | 0.00 | 0.00 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 259,606 | 265,906 | +6,300 | 4.50 | 4.15 | -0.34 | buy |
| ALPS ADVISORS INC | 53,700 | 59,403 | +5,703 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 37,332 | 42,052 | +4,720 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,406 | 18,060 | +4,654 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 64,673 | 68,518 | +3,845 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 3,000 | +3,000 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,148 | 23,054 | +2,906 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 52,917 | 55,700 | +2,783 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 16,133 | 18,300 | +2,167 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,560 | 38,536 | +1,976 | 0.00 | 0.00 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 68,475 | 70,148 | +1,673 | 0.21 | 0.20 | -0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 17,337 | 18,277 | +940 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 8,636 | 9,179 | +543 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,154 | 31,695 | +541 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 4 | 534 | +530 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 5,025 | 5,278 | +253 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 33,241 | 33,475 | +234 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 185 | +185 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 22,514 | 22,684 | +170 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 142 | +142 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Investment Solutions, Inc. /IL | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,399 | 2,499 | +100 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,060 | 1,124 | +64 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 35 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 49 | 58 | +9 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,411,571 | 5,411,571 | 0 | 2.01 | 1.85 | -0.15 | hold |
| SANDERS MORRIS HARRIS LLC | 14,900 | 14,900 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Ameritas Investment Partners, Inc. | 7,304 | 7,304 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.22 | 0.21 | -0.01 | hold |
| PRINCIPAL SECURITIES, INC. | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 227 | 227 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 610,826 | 610,826 | 0 | 2.11 | 2.05 | -0.06 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 53,738 | 53,738 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,069,627 | 7,069,627 | 0 | 6.36 | 5.94 | -0.42 | hold |
| EcoR1 Capital, LLC | 5,806,871 | 5,806,871 | 0 | 3.14 | 3.66 | +0.51 | hold |
| Rhenman & Partners Asset Management AB | 166,526 | 166,526 | 0 | 0.34 | 0.33 | -0.01 | hold |
| Foresite Capital Management IV, LLC | 1,849,947 | 1,849,947 | 0 | 19.94 | 25.59 | +5.65 | hold |
| Key FInancial Inc | 360 | 360 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rise Advisors, LLC | 531 | 531 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TCG Crossover Management, LLC | 1,423,642 | 1,423,642 | 0 | 2.40 | 3.06 | +0.65 | hold |
| Simplify Asset Management Inc. | 80,000 | 80,000 | 0 | 0.16 | 0.14 | -0.02 | hold |
| NorthCrest Asset Manangement, LLC | 10,500 | 10,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 115 | 115 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 6 | 6 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Main Street Group, LTD | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Propel Bio Management, LLC | 130,000 | 130,000 | 0 | 1.61 | 1.74 | +0.12 | hold |
| Farther Finance Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | -0.00 | hold |