| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,640,298 | 4,200,000 | +1,559,702 | 1.03 | 1.44 | +0.40 | buy |
| BlackRock, Inc. | 8,177,646 | 9,470,333 | +1,292,687 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 2,078,315 | 3,181,184 | +1,102,869 | 4.51 | 4.48 | -0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,809,539 | 2,621,522 | +811,983 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,173,125 | 1,911,886 | +738,761 | 0.01 | 0.02 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,439,259 | 8,116,000 | +676,741 | 1.99 | 1.76 | -0.22 | buy |
| JANUS HENDERSON GROUP PLC | 24,922 | 586,831 | +561,909 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 330,421 | 870,903 | +540,482 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 532,610 | 1,057,010 | +524,400 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 4,948,235 | 5,348,325 | +400,090 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 156,064 | 522,388 | +366,324 | 0.00 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 323,572 | +323,572 | 0.00 | 1.23 | +1.23 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 659,177 | 949,285 | +290,108 | 3.25 | 4.15 | +0.90 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,802,559 | 2,014,029 | +211,470 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 193,974 | 403,241 | +209,267 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 760,332 | 941,675 | +181,343 | 0.01 | 0.00 | -0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 180,000 | +180,000 | 0.00 | 0.37 | +0.37 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,563 | 232,752 | +165,189 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 278,600 | 442,500 | +163,900 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 236,947 | 399,789 | +162,842 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 158,987 | 310,238 | +151,251 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 138,846 | +138,846 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 135,647 | +135,647 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 156,185 | 284,178 | +127,993 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 116,000 | +116,000 | 0.00 | 0.84 | +0.84 | buy |
| GSA CAPITAL PARTNERS LLP | 29,022 | 141,936 | +112,914 | 0.02 | 0.06 | +0.04 | buy |
| ALGERT GLOBAL LLC | 958,492 | 1,070,139 | +111,647 | 0.16 | 0.13 | -0.03 | buy |
| GOLDMAN SACHS GROUP INC | 828,781 | 933,670 | +104,889 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 54,491 | 137,076 | +82,585 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 77,958 | +77,958 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 623,140 | 699,303 | +76,163 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 161,988 | 235,228 | +73,240 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 99,690 | 170,624 | +70,934 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 67,300 | 136,259 | +68,959 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 119,816 | 185,930 | +66,114 | 0.04 | 0.04 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 64,705 | +64,705 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 57,424 | 121,884 | +64,460 | 0.04 | 0.06 | +0.02 | buy |
| Magnetar Financial LLC | 11,984 | 76,329 | +64,345 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,923,158 | 1,984,039 | +60,881 | 0.00 | 0.00 | -0.00 | buy |
| Voss Capital, LP | 250,000 | 305,659 | +55,659 | 0.13 | 0.12 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 195,000 | 250,000 | +55,000 | 0.15 | 0.18 | +0.03 | buy |
| HRT FINANCIAL LP | 160,317 | 209,978 | +49,661 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 46,660 | +46,660 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 97,931 | 142,807 | +44,876 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 97,216 | 140,731 | +43,515 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 200,812 | 238,507 | +37,695 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 152,132 | 189,720 | +37,588 | 0.00 | 0.00 | -0.00 | buy |
| Savant Capital, LLC | 50,524 | 87,974 | +37,450 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 21,133 | 56,912 | +35,779 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 22,300 | 56,800 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 13,088 | 45,201 | +32,113 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 30,025 | +30,025 | 0.00 | 0.09 | +0.09 | buy |
| Amundi | 0 | 26,950 | +26,950 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 89,300 | 115,700 | +26,400 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.14 | +0.14 | buy |
| Cerity Partners LLC | 31,856 | 55,670 | +23,814 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 20,100 | +20,100 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 57,449 | 76,870 | +19,421 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 26,103 | 45,472 | +19,369 | 0.07 | 0.08 | +0.02 | buy |
| Legal & General Group Plc | 53,980 | 72,910 | +18,930 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 18,708 | +18,708 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 36,366 | 51,752 | +15,386 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 13,929 | +13,929 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 105,206 | 118,896 | +13,690 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 28,353 | 41,406 | +13,053 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 6,800 | 19,000 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 681,630 | 693,810 | +12,180 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,873 | +11,873 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 11,283 | +11,283 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,113 | 12,071 | +9,958 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 25,300 | 35,081 | +9,781 | 0.55 | 0.24 | -0.32 | buy |
| Jump Financial, LLC | 192,711 | 202,330 | +9,619 | 0.02 | 0.02 | -0.01 | buy |
| ADAR1 Capital Management, LLC | 25,000 | 34,300 | +9,300 | 0.03 | 0.03 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 37,944 | 47,013 | +9,069 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,718 | 39,573 | +7,855 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 23,989 | 31,546 | +7,557 | 0.02 | 0.03 | +0.01 | buy |
| Engineers Gate Manager LP | 57,536 | 62,564 | +5,028 | 0.01 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 13,383 | 17,679 | +4,296 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 138,532 | 142,662 | +4,130 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 40,982 | 44,952 | +3,970 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,552 | 16,235 | +3,683 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 10,063 | 13,304 | +3,241 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,297 | 30,273 | +2,976 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,963 | +2,963 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 75 | 2,135 | +2,060 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,908 | 21,556 | +1,648 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,198 | 17,388 | +1,190 | 0.01 | 0.01 | -0.00 | buy |
| State of Wyoming | 7,347 | 8,346 | +999 | 0.01 | 0.01 | -0.00 | buy |
| Corient Private Wealth LLC | 13,028 | 13,838 | +810 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 342 | 1,125 | +783 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,346 | 2,084 | +738 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,702 | 3,344 | +642 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 0 | 641 | +641 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 524 | 1,156 | +632 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 509 | 978 | +469 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 12,486 | 12,955 | +469 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 398 | +398 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 397 | 782 | +385 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 291 | +291 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 964 | 1,236 | +272 | 0.00 | 0.00 | +0.00 | buy |