| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,640,298 | 4,200,000 | +1,559,702 | 1.03 | 1.43 | +0.40 | buy |
| Prosight Management, LP | 2,078,315 | 3,181,184 | +1,102,869 | 4.51 | 4.48 | -0.03 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,439,259 | 8,116,000 | +676,741 | 1.82 | 1.41 | -0.41 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 659,177 | 949,285 | +290,108 | 3.25 | 4.15 | +0.90 | buy |
| ALGERT GLOBAL LLC | 958,492 | 1,070,139 | +111,647 | 0.16 | 0.13 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 119,816 | 185,930 | +66,114 | 0.04 | 0.04 | +0.01 | buy |
| Nebula Research & Development LLC | 57,424 | 121,884 | +64,460 | 0.04 | 0.06 | +0.02 | buy |
| Magnetar Financial LLC | 11,984 | 76,329 | +64,345 | 0.00 | 0.00 | +0.00 | buy |
| Voss Capital, LP | 250,000 | 305,659 | +55,659 | 0.13 | 0.12 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 195,000 | 250,000 | +55,000 | 0.15 | 0.18 | +0.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 22,300 | 56,800 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 26,103 | 45,472 | +19,369 | 0.07 | 0.08 | +0.02 | buy |
| Corton Capital Inc. | 25,300 | 35,081 | +9,781 | 0.55 | 0.24 | -0.32 | buy |
| ADAR1 Capital Management, LLC | 25,000 | 34,300 | +9,300 | 0.03 | 0.03 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 37,944 | 47,013 | +9,069 | 0.01 | 0.01 | 0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 23,989 | 31,546 | +7,557 | 0.02 | 0.03 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 138,532 | 142,662 | +4,130 | 0.00 | 0.00 | -0.00 | buy |
| Pallas Capital Advisors LLC | 10,063 | 13,304 | +3,241 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,198 | 17,388 | +1,190 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 12,252 | 11,702 | -550 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (US) LLC | 49,529 | 48,309 | -1,220 | 0.10 | 0.05 | -0.05 | sell |
| Aaron Wealth Advisors LLC | 65,786 | 63,806 | -1,980 | 0.05 | 0.04 | -0.01 | sell |
| Flower City Capital | 12,000 | 10,000 | -2,000 | 0.05 | 0.03 | -0.02 | sell |
| Virtus Investment Advisers, LLC | 16,942 | 14,119 | -2,823 | 0.03 | 0.03 | -0.00 | sell |
| PROFUND ADVISORS LLC | 27,324 | 22,357 | -4,967 | 0.01 | 0.00 | -0.00 | sell |
| 1492 Capital Management LLC | 429,746 | 423,947 | -5,799 | 1.53 | 1.13 | -0.40 | sell |
| SHERBROOKE PARK ADVISERS LLC | 40,024 | 18,619 | -21,405 | 0.12 | 0.05 | -0.08 | sell |
| Rafferty Asset Management, LLC | 131,098 | 105,110 | -25,988 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 343,522 | 235,522 | -108,000 | 0.52 | 0.32 | -0.20 | sell |
| Foresite Capital Management IV, LLC | 1,111,882 | 816,882 | -295,000 | 6.61 | 3.81 | -2.80 | sell |
| ARMISTICE CAPITAL, LLC | 6,572,000 | 6,200,000 | -372,000 | 0.65 | 0.62 | -0.03 | sell |
| TCG Crossover Management, LLC | 1,423,642 | 735,184 | -688,458 | 1.28 | 0.48 | -0.80 | sell |