| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,177,646 | 9,470,333 | +1,292,687 | 0.00 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,439,259 | 8,116,000 | +676,741 | 1.99 | 1.76 | -0.22 | buy |
| BVF INC/IL | 7,754,129 | 7,754,129 | 0 | 2.09 | 1.60 | -0.49 | hold |
| ARMISTICE CAPITAL, LLC | 6,572,000 | 6,200,000 | -372,000 | 1.16 | 1.36 | +0.20 | sell |
| VANGUARD GROUP INC | 4,948,235 | 5,348,325 | +400,090 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 2,640,298 | 4,200,000 | +1,559,702 | 1.03 | 1.44 | +0.40 | buy |
| Prosight Management, LP | 2,078,315 | 3,181,184 | +1,102,869 | 4.51 | 4.48 | -0.03 | buy |
| STATE STREET CORP | 3,282,080 | 3,036,858 | -245,222 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,809,539 | 2,621,522 | +811,983 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,802,559 | 2,014,029 | +211,470 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,923,158 | 1,984,039 | +60,881 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 1,173,125 | 1,911,886 | +738,761 | 0.01 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,362,424 | 1,242,932 | -119,492 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,544,113 | 1,103,362 | -440,751 | 0.04 | 0.02 | -0.02 | sell |
| ALGERT GLOBAL LLC | 958,492 | 1,070,139 | +111,647 | 0.16 | 0.13 | -0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 532,610 | 1,057,010 | +524,400 | 0.01 | 0.01 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 659,177 | 949,285 | +290,108 | 3.25 | 4.15 | +0.90 | buy |
| AQR CAPITAL MANAGEMENT LLC | 760,332 | 941,675 | +181,343 | 0.01 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 828,781 | 933,670 | +104,889 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 919,079 | 919,079 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 330,421 | 870,903 | +540,482 | 0.01 | 0.01 | +0.00 | buy |
| Foresite Capital Management IV, LLC | 1,111,882 | 816,882 | -295,000 | 6.61 | 3.81 | -2.80 | sell |
| TCG Crossover Management, LLC | 1,423,642 | 735,184 | -688,458 | 1.28 | 0.48 | -0.80 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 623,140 | 699,303 | +76,163 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 681,630 | 693,810 | +12,180 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 24,922 | 586,831 | +561,909 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 685,970 | 549,761 | -136,209 | 0.05 | 0.04 | -0.02 | sell |
| Man Group plc | 156,064 | 522,388 | +366,324 | 0.00 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 463,368 | 463,368 | 0 | 0.87 | 0.74 | -0.13 | hold |
| TWO SIGMA ADVISERS, LP | 278,600 | 442,500 | +163,900 | 0.00 | 0.01 | +0.00 | buy |
| 1492 Capital Management LLC | 429,746 | 423,947 | -5,799 | 1.53 | 1.13 | -0.40 | sell |
| Walleye Capital LLC | 504,857 | 414,322 | -90,535 | 0.04 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 477,603 | 405,124 | -72,479 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 193,974 | 403,241 | +209,267 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 236,947 | 399,789 | +162,842 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 394,241 | 364,155 | -30,086 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 338,859 | 336,492 | -2,367 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 0 | 323,572 | +323,572 | 0.00 | 1.23 | +1.23 | buy |
| TWO SIGMA INVESTMENTS, LP | 158,987 | 310,238 | +151,251 | 0.00 | 0.00 | +0.00 | buy |
| Voss Capital, LP | 250,000 | 305,659 | +55,659 | 0.13 | 0.12 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 1,564,866 | 302,414 | -1,262,452 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 156,185 | 284,178 | +127,993 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 195,000 | 250,000 | +55,000 | 0.15 | 0.18 | +0.03 | buy |
| Bank of New York Mellon Corp | 200,812 | 238,507 | +37,695 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 343,522 | 235,522 | -108,000 | 0.56 | 0.36 | -0.20 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 161,988 | 235,228 | +73,240 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,563 | 232,752 | +165,189 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 160,317 | 209,978 | +49,661 | 0.01 | 0.01 | -0.00 | buy |
| Jump Financial, LLC | 192,711 | 202,330 | +9,619 | 0.02 | 0.02 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 152,132 | 189,720 | +37,588 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 119,816 | 185,930 | +66,114 | 0.04 | 0.04 | +0.01 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 180,000 | +180,000 | 0.00 | 0.37 | +0.37 | buy |
| JANE STREET GROUP, LLC | 99,690 | 170,624 | +70,934 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 171,448 | 156,416 | -15,032 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 174,559 | 147,922 | -26,637 | 0.04 | 0.03 | -0.01 | sell |
| Woodline Partners LP | 145,704 | 145,704 | 0 | 0.01 | 0.00 | -0.00 | hold |
| IEQ CAPITAL, LLC | 97,931 | 142,807 | +44,876 | 0.01 | 0.01 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 138,532 | 142,662 | +4,130 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 29,022 | 141,936 | +112,914 | 0.02 | 0.06 | +0.04 | buy |
| Invesco Ltd. | 97,216 | 140,731 | +43,515 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 418,988 | 140,713 | -278,275 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 138,846 | +138,846 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 54,491 | 137,076 | +82,585 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 67,300 | 136,259 | +68,959 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 135,647 | +135,647 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 57,424 | 121,884 | +64,460 | 0.04 | 0.06 | +0.02 | buy |
| RHUMBLINE ADVISERS | 105,206 | 118,896 | +13,690 | 0.00 | 0.00 | -0.00 | buy |
| Rangeley Capital, LLC | 0 | 116,000 | +116,000 | 0.00 | 0.84 | +0.84 | buy |
| Swiss National Bank | 89,300 | 115,700 | +26,400 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 139,525 | 112,283 | -27,242 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 131,098 | 105,110 | -25,988 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Rosalind Advisors, Inc. | 100,000 | 100,000 | 0 | 0.32 | 0.28 | -0.04 | hold |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 349,017 | 92,691 | -256,326 | 0.00 | 0.00 | -0.00 | sell |
| Savant Capital, LLC | 50,524 | 87,974 | +37,450 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 77,958 | +77,958 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 57,449 | 76,870 | +19,421 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 11,984 | 76,329 | +64,345 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 53,980 | 72,910 | +18,930 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 64,705 | +64,705 | 0.00 | 0.00 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 65,786 | 63,806 | -1,980 | 0.05 | 0.04 | -0.01 | sell |
| Engineers Gate Manager LP | 57,536 | 62,564 | +5,028 | 0.01 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 60,847 | 60,847 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 21,133 | 56,912 | +35,779 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 22,300 | 56,800 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 31,856 | 55,670 | +23,814 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 36,366 | 51,752 | +15,386 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 60,118 | 48,532 | -11,586 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (US) LLC | 49,529 | 48,309 | -1,220 | 0.10 | 0.05 | -0.05 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,008 | 48,050 | -1,958 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 37,944 | 47,013 | +9,069 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 46,660 | +46,660 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 26,103 | 45,472 | +19,369 | 0.07 | 0.08 | +0.02 | buy |
| FMR LLC | 13,088 | 45,201 | +32,113 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 40,982 | 44,952 | +3,970 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,923 | 44,923 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 392,049 | 42,363 | -349,686 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 28,353 | 41,406 | +13,053 | 0.00 | 0.00 | +0.00 | buy |