| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 9,637,531 | 10,509,233 | +871,702 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,575,422 | 8,575,422 | 0 | 1.89 | 1.98 | +0.09 | hold |
| BVF INC/IL | 8,445,769 | 8,445,769 | 0 | 2.19 | 2.37 | +0.18 | hold |
| STATE STREET CORP | 4,511,891 | 5,329,208 | +817,317 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 3,736,000 | 3,678,000 | -58,000 | 1.00 | 1.12 | +0.11 | sell |
| AQR CAPITAL MANAGEMENT LLC | 2,124,480 | 3,126,727 | +1,002,247 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,433,471 | 2,265,171 | +831,700 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,034,276 | 2,229,958 | +195,682 | 0.00 | 0.00 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 1,529,369 | 2,167,938 | +638,569 | 6.68 | 9.85 | +3.17 | buy |
| Prosight Management, LP | 3,356,700 | 2,021,964 | -1,334,736 | 4.48 | 3.82 | -0.65 | sell |
| Deep Track Capital, LP | 2,643,542 | 1,978,565 | -664,977 | 0.44 | 0.32 | -0.12 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,582,568 | 1,663,765 | +81,197 | 0.02 | 0.03 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 1,410,275 | +1,410,275 | 0.00 | 0.01 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 1,064,880 | 1,174,880 | +110,000 | 0.95 | 1.27 | +0.32 | buy |
| Qube Research & Technologies Ltd | 1,636,733 | 1,169,884 | -466,849 | 0.02 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,425,945 | 1,169,189 | -256,756 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,230,131 | 1,160,921 | -69,210 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 1,163,977 | 1,160,310 | -3,667 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 800,597 | 996,114 | +195,517 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 1,040,233 | 964,636 | -75,597 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 602,231 | 948,974 | +346,743 | 0.02 | 0.04 | +0.02 | buy |
| NORTHERN TRUST CORP | 756,273 | 831,160 | +74,887 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,565,143 | 711,332 | -853,811 | 0.01 | 0.01 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 676,400 | +676,400 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 690,817 | 676,400 | -14,417 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 505,452 | 675,044 | +169,592 | 0.06 | 0.07 | +0.01 | buy |
| Fisher Asset Management, LLC | 675,305 | 625,936 | -49,369 | 0.00 | 0.00 | +0.00 | sell |
| ROYCE & ASSOCIATES LP | 0 | 609,985 | +609,985 | 0.00 | 0.05 | +0.05 | buy |
| Rhenman & Partners Asset Management AB | 271,500 | 591,500 | +320,000 | 0.27 | 0.61 | +0.34 | buy |
| Hennion & Walsh Asset Management, Inc. | 335,212 | 568,845 | +233,633 | 0.09 | 0.18 | +0.09 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 509,886 | +509,886 | 0.00 | 0.03 | +0.03 | buy |
| 1492 Capital Management LLC | 486,123 | 467,153 | -18,970 | 1.50 | 1.51 | +0.01 | sell |
| SECTOR GAMMA AS | 411,810 | 433,012 | +21,202 | 0.79 | 1.03 | +0.24 | buy |
| Man Group plc | 475,027 | 432,908 | -42,119 | 0.01 | 0.01 | +0.00 | sell |
| FMR LLC | 317,652 | 363,342 | +45,690 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 281,904 | 348,125 | +66,221 | 0.01 | 0.02 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 343,891 | 343,891 | 0 | 0.04 | 0.06 | +0.02 | hold |
| CITADEL ADVISORS LLC | 368,825 | 328,105 | -40,720 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 295,522 | 295,039 | -483 | 0.41 | 0.46 | +0.05 | sell |
| Ally Bridge Group (NY) LLC | 0 | 290,000 | +290,000 | 0.00 | 4.10 | +4.10 | buy |
| PRUDENTIAL FINANCIAL INC | 41,280 | 267,950 | +226,670 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 339,712 | 267,748 | -71,964 | 0.00 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 339,599 | 259,857 | -79,742 | 0.02 | 0.02 | -0.00 | sell |
| Bank of New York Mellon Corp | 254,325 | 257,767 | +3,442 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 52,572 | 245,920 | +193,348 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 201,696 | 232,429 | +30,733 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 449,024 | 214,747 | -234,277 | 0.01 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 89,303 | 206,728 | +117,425 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 226,160 | 204,614 | -21,546 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 206,771 | 198,236 | -8,535 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 528,704 | 183,731 | -344,973 | 0.03 | 0.01 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 357,955 | 167,581 | -190,374 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 151,863 | 166,670 | +14,807 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 319,266 | 162,110 | -157,156 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 116,042 | 159,724 | +43,682 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 158,850 | 159,310 | +460 | 0.00 | 0.00 | +0.00 | buy |
| Swedbank AB | 0 | 152,900 | +152,900 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 92,811 | 148,257 | +55,446 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 145,704 | 145,704 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 145,600 | 145,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 154,393 | 143,568 | -10,825 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 137,800 | 133,748 | -4,052 | 0.01 | 0.02 | +0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 117,694 | 128,892 | +11,198 | 0.02 | 0.03 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 82,610 | 128,495 | +45,885 | 0.19 | 0.33 | +0.14 | buy |
| CITIGROUP INC | 53,995 | 126,752 | +72,757 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 101,022 | 124,082 | +23,060 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 52,321 | 122,709 | +70,388 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 124,153 | 122,645 | -1,508 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 235,868 | 120,568 | -115,300 | 0.44 | 0.25 | -0.18 | sell |
| Russell Investments Group, Ltd. | 83,533 | 112,460 | +28,927 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 104,815 | 108,540 | +3,725 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 100,000 | 100,000 | 0 | 0.33 | 0.41 | +0.08 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 37,447 | 95,270 | +57,823 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 89,032 | 94,810 | +5,778 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 486,570 | 94,198 | -392,372 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 101,220 | 94,000 | -7,220 | 0.89 | 0.96 | +0.07 | sell |
| Tidal Investments LLC | 0 | 93,761 | +93,761 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 93,761 | +93,761 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 95,317 | 92,793 | -2,524 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 88,739 | 91,003 | +2,264 | 0.00 | 0.00 | +0.00 | buy |
| Xcel Wealth Management, LLC | 95,393 | 90,983 | -4,410 | 0.22 | 0.24 | +0.02 | sell |
| ALPS ADVISORS INC | 71,906 | 90,093 | +18,187 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 134,152 | 85,486 | -48,666 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 36,032 | 79,588 | +43,556 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 31,471 | 78,914 | +47,443 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 663,350 | 74,383 | -588,967 | 0.01 | 0.00 | -0.01 | sell |
| Jain Global LLC | 13,463 | 72,830 | +59,367 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 71,480 | 71,480 | 0 | 0.50 | 0.55 | +0.05 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,094 | 69,962 | +11,868 | 0.00 | 0.00 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 66,840 | 67,455 | +615 | 0.03 | 0.04 | +0.01 | buy |
| SG Americas Securities, LLC | 49,816 | 63,396 | +13,580 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 71,660 | 61,444 | -10,216 | 0.00 | 0.00 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 55,530 | 57,776 | +2,246 | 0.04 | 0.04 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,363 | 57,143 | +10,780 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 102,157 | 56,640 | -45,517 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 857,474 | 56,600 | -800,874 | 0.61 | 0.04 | -0.57 | sell |
| Quadrature Capital Ltd | 12,227 | 55,714 | +43,487 | 0.00 | 0.01 | +0.00 | buy |
| Knott David M Jr | 52,767 | 52,767 | 0 | 0.26 | 0.31 | +0.05 | hold |