| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,238,000 | 4,374,044 | +1,136,044 | 0.73 | 0.88 | +0.15 | buy |
| Prosight Management, LP | 1,343,359 | 1,932,456 | +589,097 | 4.16 | 5.59 | +1.42 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,028,442 | 7,335,845 | +307,403 | 3.98 | 3.62 | -0.36 | buy |
| Paradigm Biocapital Advisors LP | 1,004,908 | 1,212,828 | +207,920 | 0.86 | 0.75 | -0.11 | buy |
| DAFNA Capital Management LLC | 357,784 | 550,784 | +193,000 | 1.04 | 1.56 | +0.53 | buy |
| ALGERT GLOBAL LLC | 187,065 | 365,024 | +177,959 | 0.09 | 0.16 | 0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,124,000 | 2,236,000 | +112,000 | 0.56 | 0.61 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 603,287 | 703,287 | +100,000 | 1.37 | 1.54 | +0.17 | buy |
| JUPITER ASSET MANAGEMENT LTD | 17,317 | 57,877 | +40,560 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 197,633 | 232,207 | +34,574 | 0.01 | 0.01 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 333,445 | 350,445 | +17,000 | 3.77 | 3.93 | +0.15 | buy |
| ALPS ADVISORS INC | 50,308 | 54,749 | +4,441 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 36,393 | 39,621 | +3,228 | 0.02 | 0.02 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 48,687 | 50,700 | +2,013 | 0.03 | 0.03 | -0.00 | buy |
| E Fund Management Co., Ltd. | 10,628 | 11,929 | +1,301 | 0.01 | 0.01 | -0.00 | buy |
| Corton Capital Inc. | 17,391 | 18,409 | +1,018 | 0.09 | 0.08 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 897 | 1,898 | +1,001 | 0.00 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,480 | 8,624 | -856 | 0.06 | 0.05 | -0.01 | sell |
| Aaron Wealth Advisors LLC | 56,635 | 52,196 | -4,439 | 0.08 | 0.06 | -0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 709,118 | 702,093 | -7,025 | 5.08 | 4.66 | -0.43 | sell |
| Graham Capital Management, L.P. | 30,618 | 21,131 | -9,487 | 0.01 | 0.01 | -0.01 | sell |
| Inspire Advisors, LLC | 75,888 | 37,698 | -38,190 | 0.15 | 0.06 | -0.09 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 66,154 | 21,222 | -44,932 | 0.01 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 910,317 | 856,535 | -53,782 | 3.79 | 2.55 | -1.24 | sell |
| Avoro Capital Advisors LLC | 3,105,000 | 2,980,000 | -125,000 | 0.45 | 0.42 | -0.02 | sell |