| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 384,756 | 1,963,505 | +1,578,749 | 0.24 | 1.22 | +0.99 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,069,627 | 7,652,782 | +583,155 | 5.35 | 4.78 | -0.56 | buy |
| ARMISTICE CAPITAL, LLC | 2,350,000 | 2,658,000 | +308,000 | 0.61 | 0.83 | +0.22 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 265,906 | 553,542 | +287,636 | 4.15 | 7.81 | +3.66 | buy |
| Commodore Capital LP | 1,593,350 | 1,800,000 | +206,650 | 2.24 | 2.20 | -0.04 | buy |
| Eversept Partners, LP | 72,317 | 192,398 | +120,081 | 0.10 | 0.26 | +0.16 | buy |
| Prosight Management, LP | 629,900 | 705,109 | +75,209 | 3.88 | 3.39 | -0.49 | buy |
| Affinity Asset Advisors, LLC | 650,000 | 687,785 | +37,785 | 2.11 | 2.09 | -0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 163,000 | 197,000 | +34,000 | 2.83 | 3.12 | +0.29 | buy |
| BIT Capital GmbH | 30,184 | 60,631 | +30,447 | 0.05 | 0.11 | +0.06 | buy |
| ALGERT GLOBAL LLC | 260,783 | 272,276 | +11,493 | 0.18 | 0.14 | 0.00 | buy |
| Knott David M Jr | 10,000 | 19,000 | +9,000 | 0.08 | 0.13 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 38,790 | 47,295 | +8,505 | 0.06 | 0.04 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,951 | 14,739 | +5,788 | 0.03 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 23,567 | 18,868 | +4,699 | 0.02 | 0.01 | 0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 38,181 | 42,726 | +4,545 | 0.47 | 0.40 | -0.07 | buy |
| HighVista Strategies LLC | 16,764 | 21,161 | +4,397 | 0.13 | 0.14 | +0.02 | buy |
| Bellevue Group AG | 10,000 | 13,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 9,500 | 6,000 | +3,500 | 0.08 | 0.04 | 0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,700 | 26,667 | +2,967 | 0.04 | 0.04 | -0.00 | buy |
| 1492 Capital Management LLC | 72,738 | 73,224 | +486 | 0.85 | 0.71 | -0.13 | buy |
| NorthCrest Asset Manangement, LLC | 10,500 | 10,687 | +187 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,197 | 4,275 | +78 | 0.04 | 0.04 | -0.00 | buy |
| ALPS ADVISORS INC | 59,403 | 58,695 | -708 | 0.01 | 0.01 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 610,826 | 610,087 | -739 | 1.72 | 1.90 | +0.18 | sell |
| J. Goldman & Co LP | 32,721 | 31,654 | -1,067 | 0.02 | 0.02 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 102,917 | 100,875 | -2,042 | 0.41 | 0.36 | -0.05 | sell |
| Aaron Wealth Advisors LLC | 70,148 | 67,991 | -2,157 | 0.20 | 0.16 | -0.04 | sell |
| Hennion & Walsh Asset Management, Inc. | 127,619 | 124,169 | -3,450 | 0.13 | 0.11 | -0.02 | sell |
| Ally Bridge Group (NY) LLC | 306,762 | 294,081 | -12,681 | 3.76 | 3.08 | -0.69 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 24,340 | 10,831 | -13,509 | 0.09 | 0.05 | -0.05 | sell |
| DAFNA Capital Management LLC | 423,500 | 408,368 | -15,132 | 2.08 | 1.89 | -0.20 | sell |
| Rafferty Asset Management, LLC | 124,585 | 91,737 | -32,848 | 0.01 | 0.01 | -0.00 | sell |
| Exome Asset Management LLC | 131,742 | 90,305 | -41,437 | 2.42 | 1.19 | -1.22 | sell |
| Paradigm Biocapital Advisors LP | 4,539,381 | 4,331,321 | -208,060 | 3.58 | 2.96 | -0.62 | sell |
| Sofinnova Investments, Inc. | 825,243 | 296,884 | -528,359 | 0.88 | 0.46 | -0.42 | sell |
| BVF INC/IL | 4,082,037 | 3,371,761 | -710,276 | 2.36 | 1.93 | -0.43 | sell |