| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 384,756 | 1,963,505 | +1,578,749 | 0.24 | 1.22 | +0.99 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,069,627 | 7,652,782 | +583,155 | 5.94 | 5.37 | -0.57 | buy |
| MILLENNIUM MANAGEMENT LLC | 339,482 | 845,194 | +505,712 | 0.01 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 75,081 | 571,365 | +496,284 | 0.02 | 0.12 | +0.10 | buy |
| ARMISTICE CAPITAL, LLC | 2,350,000 | 2,658,000 | +308,000 | 1.27 | 1.36 | +0.09 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 265,906 | 553,542 | +287,636 | 4.15 | 7.81 | +3.66 | buy |
| Commodore Capital LP | 1,593,350 | 1,800,000 | +206,650 | 2.24 | 2.20 | -0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 189,103 | +189,103 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,013,143 | 1,188,995 | +175,852 | 0.02 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 4,040,456 | 4,203,687 | +163,231 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 894,619 | 1,053,764 | +159,145 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 72,317 | 192,398 | +120,081 | 0.11 | 0.29 | +0.17 | buy |
| Qube Research & Technologies Ltd | 0 | 103,069 | +103,069 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 80,921 | 165,484 | +84,563 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 629,900 | 705,109 | +75,209 | 3.88 | 3.49 | -0.38 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 60,847 | +60,847 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 54,971 | +54,971 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 375,734 | 423,208 | +47,474 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 45,927 | +45,927 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,738,974 | 1,780,509 | +41,535 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 81,655 | 122,515 | +40,860 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 91,777 | 129,816 | +38,039 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 650,000 | 687,785 | +37,785 | 2.11 | 2.09 | -0.02 | buy |
| Russell Investments Group, Ltd. | 218,442 | 252,770 | +34,328 | 0.01 | 0.01 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 163,000 | 197,000 | +34,000 | 2.83 | 3.12 | +0.29 | buy |
| JANE STREET GROUP, LLC | 92,237 | 126,085 | +33,848 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 33,797 | +33,797 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 33,333 | 65,010 | +31,677 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 30,508 | +30,508 | 0.00 | 0.06 | +0.06 | buy |
| BIT Capital GmbH | 30,184 | 60,631 | +30,447 | 0.06 | 0.11 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.10 | +0.10 | buy |
| FRANKLIN RESOURCES INC | 1,565,288 | 1,588,401 | +23,113 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 663,621 | 685,167 | +21,546 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 68,518 | 86,431 | +17,913 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 2,600 | 18,700 | +16,100 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 15,257 | +15,257 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 610,846 | 624,952 | +14,106 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 13,720 | +13,720 | 0.00 | 0.05 | +0.05 | buy |
| ALGERT GLOBAL LLC | 260,783 | 272,276 | +11,493 | 0.18 | 0.14 | -0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,129 | 15,287 | +11,158 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 33,475 | 43,488 | +10,013 | 0.00 | 0.00 | +0.00 | buy |
| Long Corridor Asset Management Ltd | 0 | 10,000 | +10,000 | 0.00 | 0.17 | +0.17 | buy |
| Knott David M Jr | 10,000 | 19,000 | +9,000 | 0.08 | 0.13 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 38,790 | 47,295 | +8,505 | 0.06 | 0.04 | -0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 21,933 | 29,655 | +7,722 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 7,483 | +7,483 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 8,951 | 14,739 | +5,788 | 0.03 | 0.03 | +0.01 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 38,181 | 42,726 | +4,545 | 0.47 | 0.40 | -0.07 | buy |
| Trexquant Investment LP | 54,064 | 58,583 | +4,519 | 0.02 | 0.01 | -0.00 | buy |
| HighVista Strategies LLC | 16,764 | 21,161 | +4,397 | 0.13 | 0.14 | +0.02 | buy |
| ProShare Advisors LLC | 14,155 | 18,230 | +4,075 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 10,000 | 13,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 406,149 | 409,241 | +3,092 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,700 | 26,667 | +2,967 | 0.04 | 0.04 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,484 | 43,414 | +2,930 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 7,070 | 8,565 | +1,495 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 1,300 | +1,300 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 534 | 1,236 | +702 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 3,000 | 3,700 | +700 | 0.02 | 0.02 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,054 | 23,726 | +672 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,875 | 11,464 | +589 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,274 | 2,772 | +498 | 0.00 | 0.00 | +0.00 | buy |
| 1492 Capital Management LLC | 72,738 | 73,224 | +486 | 0.85 | 0.72 | -0.13 | buy |
| Jaffetilchin Investment Partners, LLC | 0 | 350 | +350 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 43,702 | 44,007 | +305 | 0.01 | 0.00 | -0.00 | buy |
| ASHTON THOMAS SECURITIES, LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| NorthCrest Asset Manangement, LLC | 10,500 | 10,687 | +187 | 0.01 | 0.01 | -0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,197 | 4,275 | +78 | 0.04 | 0.04 | -0.00 | buy |
| Daiwa Securities Group Inc. | 227 | 297 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 185 | 232 | +47 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 35 | 70 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 15 | 27 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,124 | 1,136 | +12 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 8 | 18 | +10 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,411,571 | 5,411,571 | 0 | 1.85 | 1.58 | -0.27 | hold |
| CANADA LIFE ASSURANCE Co | 17,836 | 17,836 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 14,900 | 14,900 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,304 | 7,304 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.21 | 0.14 | -0.07 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 41,874 | 41,874 | 0 | 0.03 | 0.04 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 24,922 | 24,922 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,060 | 18,060 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 42,052 | 42,052 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 53,738 | 53,738 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Allianz Asset Management GmbH | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Candriam S.C.A. | 906,482 | 906,482 | 0 | 0.11 | 0.10 | -0.01 | hold |
| Arax Advisory Partners | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 5,806,871 | 5,806,871 | 0 | 3.66 | 3.89 | +0.23 | hold |
| Rhenman & Partners Asset Management AB | 166,526 | 166,526 | 0 | 0.33 | 0.26 | -0.07 | hold |
| Avoro Capital Advisors LLC | 3,541,505 | 3,541,505 | 0 | 0.97 | 1.01 | +0.04 | hold |
| Parallel Advisors, LLC | 172 | 172 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Holocene Advisors, LP | 2,689,456 | 2,689,456 | 0 | 0.23 | 0.21 | -0.02 | hold |
| Foresite Capital Management IV, LLC | 1,849,947 | 1,849,947 | 0 | 25.59 | 23.62 | -1.97 | hold |