| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 9,470,333 | 9,515,135 | +44,802 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 7,754,129 | 8,617,162 | +863,033 | 1.60 | 3.09 | +1.49 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,116,000 | 8,116,000 | 0 | 1.76 | 2.18 | +0.41 | hold |
| VANGUARD GROUP INC | 5,348,325 | 5,468,522 | +120,197 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 6,200,000 | 4,672,000 | -1,528,000 | 1.36 | 1.30 | -0.06 | sell |
| STATE STREET CORP | 3,036,858 | 3,343,131 | +306,273 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 3,181,184 | 2,758,516 | -422,668 | 4.48 | 5.86 | +1.39 | sell |
| GOLDMAN SACHS GROUP INC | 933,670 | 2,614,726 | +1,681,056 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 941,675 | 2,242,192 | +1,300,517 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,103,362 | 2,224,590 | +1,121,228 | 0.02 | 0.08 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,621,522 | 2,093,702 | -527,820 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,014,029 | 2,047,926 | +33,897 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,984,039 | 1,813,064 | -170,975 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 1,911,886 | 1,712,716 | -199,170 | 0.02 | 0.02 | +0.01 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 949,285 | 1,388,794 | +439,509 | 4.15 | 7.91 | +3.77 | buy |
| Assenagon Asset Management S.A. | 919,079 | 1,265,030 | +345,951 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,242,932 | 1,139,365 | -103,567 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 870,903 | 1,060,829 | +189,926 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 1,070,139 | 1,011,945 | -58,194 | 0.13 | 0.15 | +0.02 | sell |
| EcoR1 Capital, LLC | 4,200,000 | 872,500 | -3,327,500 | 1.44 | 0.37 | -1.07 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,057,010 | 865,310 | -191,700 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 364,155 | 808,818 | +444,663 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 693,810 | 753,600 | +59,790 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 699,303 | 711,896 | +12,593 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 232,752 | 669,046 | +436,294 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 20,100 | 607,790 | +587,690 | 0.01 | 0.59 | +0.58 | buy |
| BANK OF AMERICA CORP /DE/ | 405,124 | 572,175 | +167,051 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 250,000 | 490,000 | +240,000 | 0.18 | 0.48 | +0.30 | buy |
| MARSHALL WACE, LLP | 42,363 | 488,753 | +446,390 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 112,283 | 485,570 | +373,287 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 463,368 | 463,368 | 0 | 0.74 | 1.01 | +0.28 | hold |
| Man Group plc | 522,388 | 458,264 | -64,124 | 0.01 | 0.01 | +0.00 | sell |
| 1492 Capital Management LLC | 423,947 | 445,640 | +21,693 | 1.13 | 1.60 | +0.47 | buy |
| SECTOR GAMMA AS | 0 | 438,415 | +438,415 | 0.00 | 0.96 | +0.96 | buy |
| Nuveen, LLC | 399,789 | 399,789 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 323,572 | 395,872 | +72,300 | 1.23 | 2.16 | +0.93 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,416 | 386,956 | +230,540 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 403,241 | 376,879 | -26,362 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 209,978 | 368,557 | +158,579 | 0.01 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 364,932 | +364,932 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 343,891 | +343,891 | 0.00 | 0.05 | +0.05 | buy |
| Russell Investments Group, Ltd. | 336,492 | 327,970 | -8,522 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 12,955 | 327,564 | +314,609 | 0.00 | 0.00 | +0.00 | buy |
| Voss Capital, LP | 305,659 | 305,659 | 0 | 0.12 | 0.16 | +0.03 | hold |
| CITIGROUP INC | 284,178 | 295,023 | +10,845 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 142,807 | 274,086 | +131,279 | 0.01 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 0 | 263,628 | +263,628 | 0.00 | 0.18 | +0.18 | buy |
| Bank of New York Mellon Corp | 238,507 | 255,240 | +16,733 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 170,624 | 245,822 | +75,198 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 235,522 | 245,522 | +10,000 | 0.36 | 0.52 | +0.16 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 230,880 | +230,880 | 0.00 | 0.20 | +0.20 | buy |
| FRANKLIN RESOURCES INC | 302,414 | 228,444 | -73,970 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 549,761 | 215,043 | -334,718 | 0.04 | 0.02 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 185,930 | 214,850 | +28,920 | 0.04 | 0.07 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 310,238 | 204,725 | -105,513 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 140,731 | 182,687 | +41,956 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 136,259 | 177,055 | +40,796 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,209 | 146,171 | +141,962 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 145,704 | 145,704 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Swiss National Bank | 115,700 | 134,300 | +18,600 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 137,076 | 131,192 | -5,884 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 442,500 | 126,200 | -316,300 | 0.01 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 124,900 | +124,900 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 116,000 | 120,000 | +4,000 | 0.84 | 1.00 | +0.16 | buy |
| RHUMBLINE ADVISERS | 118,896 | 119,935 | +1,039 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 41,406 | 118,363 | +76,957 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 141,936 | 117,590 | -24,346 | 0.06 | 0.09 | +0.03 | sell |
| Rafferty Asset Management, LLC | 105,110 | 113,222 | +8,112 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 189,720 | 110,766 | -78,954 | 0.00 | 0.00 | -0.00 | sell |
| Xcel Wealth Management, LLC | 0 | 102,321 | +102,321 | 0.00 | 0.24 | +0.24 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Rosalind Advisors, Inc. | 100,000 | 100,000 | 0 | 0.28 | 0.31 | +0.03 | hold |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cerity Partners LLC | 55,670 | 93,844 | +38,174 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 56,912 | 91,055 | +34,143 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 45,201 | 86,874 | +41,673 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 135,647 | 86,798 | -48,849 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 83,748 | +83,748 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 72,910 | 78,350 | +5,440 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 76,870 | 78,041 | +1,171 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 76,627 | +76,627 | 0.00 | 0.02 | +0.02 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 56,800 | 69,300 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 69,040 | +69,040 | 0.00 | 0.01 | +0.01 | buy |
| Savant Capital, LLC | 87,974 | 68,879 | -19,095 | 0.00 | 0.00 | +0.00 | sell |
| Knott David M Jr | 0 | 67,302 | +67,302 | 0.00 | 0.25 | +0.25 | buy |
| Aaron Wealth Advisors LLC | 63,806 | 67,146 | +3,340 | 0.04 | 0.04 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,923 | 65,867 | +20,944 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 138,846 | 64,549 | -74,297 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 51,752 | 62,825 | +11,073 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 10,757 | 62,013 | +51,256 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 60,847 | 60,847 | 0 | 0.00 | 0.00 | +0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 58,951 | +58,951 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 142,662 | 56,731 | -85,931 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 34,300 | 55,000 | +20,700 | 0.03 | 0.05 | +0.02 | buy |
| SG Americas Securities, LLC | 0 | 48,304 | +48,304 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 13,929 | 47,690 | +33,761 | 0.00 | 0.01 | +0.01 | buy |
| Lion Point Capital, LP | 0 | 46,000 | +46,000 | 0.00 | 2.31 | +2.31 | buy |
| MetLife Investment Management, LLC | 44,952 | 45,369 | +417 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 44,877 | +44,877 | 0.00 | 0.01 | +0.01 | buy |