| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 0 | 1,667,321 | +1,667,321 | 0.00 | 1.34 | +1.34 | buy |
| MORGAN STANLEY | 160,963 | 1,330,955 | +1,169,992 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,374,044 | 5,312,733 | +938,689 | 0.88 | 1.41 | +0.53 | buy |
| BVF INC/IL | 6,730,983 | 7,373,228 | +642,245 | 1.66 | 2.65 | +1.00 | buy |
| BANK OF AMERICA CORP /DE/ | 170,456 | 751,341 | +580,885 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 465,593 | +465,593 | 0.00 | 0.07 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 31,688 | 354,279 | +322,591 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,804,224 | 2,001,754 | +197,530 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 115,600 | 278,100 | +162,500 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,222,955 | 1,353,665 | +130,710 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 82,345 | 202,957 | +120,612 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,924,448 | 4,037,691 | +113,243 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 98,315 | +98,315 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 94,279 | +94,279 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 89,131 | +89,131 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 0 | 88,889 | +88,889 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,577,956 | 1,656,009 | +78,053 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 50,700 | 127,643 | +76,943 | 0.03 | 0.10 | +0.08 | buy |
| Hudson Bay Capital Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 460,797 | 531,562 | +70,765 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 30,000 | 95,000 | +65,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 56,363 | +56,363 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 155,245 | 207,272 | +52,027 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,212,828 | 1,262,828 | +50,000 | 0.75 | 0.85 | +0.10 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,084 | 93,153 | +44,069 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 54,251 | 91,801 | +37,550 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 79,518 | 113,715 | +34,197 | 0.02 | 0.04 | +0.02 | buy |
| Russell Investments Group, Ltd. | 195,967 | 224,784 | +28,817 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 36,715 | 64,027 | +27,312 | 0.01 | 0.02 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 25,211 | +25,211 | 0.00 | 0.00 | +0.00 | buy |
| ADVISORY RESEARCH INC | 0 | 24,804 | +24,804 | 0.00 | 0.06 | +0.06 | buy |
| Pale Fire Capital SE | 10,050 | 31,050 | +21,000 | 0.01 | 0.07 | +0.06 | buy |
| Point72 Middle East FZE | 0 | 20,366 | +20,366 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 3,575 | 23,155 | +19,580 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 18,917 | +18,917 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 48,520 | 67,266 | +18,746 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 77,231 | 95,159 | +17,928 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 563,421 | 579,987 | +16,566 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 12,219 | +12,219 | 0.00 | 0.09 | +0.09 | buy |
| Brevan Howard Capital Management LP | 0 | 11,891 | +11,891 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 58,895 | 69,127 | +10,232 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 11,852 | 20,773 | +8,921 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,643 | 31,709 | +8,066 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 215 | 7,545 | +7,330 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,596 | 16,393 | +6,797 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,898 | 8,590 | +6,692 | 0.01 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 33,237 | 37,826 | +4,589 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 705,378 | 709,820 | +4,442 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 10,581 | 14,175 | +3,594 | 0.00 | 0.01 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,866 | 6,268 | +3,402 | 0.00 | 0.00 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 52,196 | 54,946 | +2,750 | 0.06 | 0.13 | +0.07 | buy |
| ProShare Advisors LLC | 14,019 | 16,426 | +2,407 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 48 | 1,690 | +1,642 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 3,589 | 5,038 | +1,449 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 110,876 | 112,063 | +1,187 | 0.00 | 0.00 | +0.00 | buy |
| 1492 Capital Management LLC | 100,466 | 101,500 | +1,034 | 0.59 | 0.83 | +0.24 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,871 | 27,845 | +974 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,475 | 7,304 | +829 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,446 | 2,097 | +651 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 28,736 | 29,159 | +423 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 233 | +233 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 974 | 990 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 14,900 | 14,900 | 0 | 0.03 | 0.11 | +0.09 | hold |
| ALLIANCEBERNSTEIN L.P. | 80,100 | 80,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JUPITER ASSET MANAGEMENT LTD | 57,877 | 57,877 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Daiwa Securities Group Inc. | 227 | 227 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 703,287 | 703,287 | 0 | 1.54 | 1.88 | +0.34 | hold |
| MetLife Investment Management, LLC | 37,332 | 37,332 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Assenagon Asset Management S.A. | 1,153,845 | 1,153,845 | 0 | 0.04 | 0.05 | +0.01 | hold |
| ALETHEA CAPITAL MANAGEMENT, LLC | 350,445 | 350,445 | 0 | 3.93 | 5.81 | +1.89 | hold |
| EcoR1 Capital, LLC | 5,806,871 | 5,806,871 | 0 | 1.80 | 2.17 | +0.36 | hold |
| Avoro Capital Advisors LLC | 2,980,000 | 2,980,000 | 0 | 0.42 | 0.59 | +0.17 | hold |
| Holocene Advisors, LP | 2,437,463 | 2,437,463 | 0 | 0.10 | 0.14 | +0.04 | hold |
| Foresite Capital Management IV, LLC | 1,849,947 | 1,849,947 | 0 | 9.37 | 13.44 | +4.07 | hold |
| Key FInancial Inc | 360 | 360 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 1,423,642 | 1,423,642 | 0 | 1.91 | 2.27 | +0.36 | hold |
| Simplify Asset Management Inc. | 80,000 | 80,000 | 0 | 0.12 | 0.18 | +0.06 | hold |
| NorthCrest Asset Manangement, LLC | 10,500 | 10,500 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Washington Trust Advisors, Inc. | 115 | 115 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 11,000 | 11,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 11,295 | 11,295 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 4,127 | 4,127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 53,585 | 53,585 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 81,856 | 81,856 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 21,222 | 21,222 | 0 | 0.00 | 0.01 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 22,684 | 22,684 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 11 | 10 | -1 | 0.00 | 0.00 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 25,335 | 25,261 | -74 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 35,216 | 35,074 | -142 | 0.00 | 0.00 | -0.00 | sell |
| Glassman Wealth Services | 183 | 0 | -183 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 215 | 0 | -215 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 350 | 0 | -350 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 413 | 0 | -413 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 6,824 | 6,162 | -662 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 702,093 | 701,349 | -744 | 4.66 | 5.68 | +1.02 | sell |
| VIRTUS ADVISERS, LLC | 8,624 | 7,747 | -877 | 0.05 | 0.07 | +0.02 | sell |
| Bank of New York Mellon Corp | 261,744 | 260,789 | -955 | 0.00 | 0.00 | +0.00 | sell |