| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,374,044 | 5,312,733 | +938,689 | 0.88 | 1.41 | +0.53 | buy |
| BVF INC/IL | 6,730,983 | 7,373,228 | +642,245 | 1.66 | 2.65 | +1.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 50,700 | 127,643 | +76,943 | 0.03 | 0.10 | +0.08 | buy |
| Paradigm Biocapital Advisors LP | 1,212,828 | 1,262,828 | +50,000 | 0.75 | 0.85 | +0.10 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 79,518 | 113,715 | +34,197 | 0.02 | 0.04 | +0.02 | buy |
| ALGERT GLOBAL LLC | 365,024 | 333,450 | +31,574 | 0.16 | 0.19 | 0.00 | sell |
| Pale Fire Capital SE | 10,050 | 31,050 | +21,000 | 0.01 | 0.07 | +0.06 | buy |
| PROFUND ADVISORS LLC | 39,621 | 25,588 | +14,033 | 0.02 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,898 | 8,590 | +6,692 | 0.01 | 0.02 | +0.02 | buy |
| Aaron Wealth Advisors LLC | 52,196 | 54,946 | +2,750 | 0.06 | 0.13 | +0.07 | buy |
| 1492 Capital Management LLC | 100,466 | 101,500 | +1,034 | 0.59 | 0.83 | +0.24 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 702,093 | 701,349 | -744 | 4.29 | 5.68 | +1.39 | sell |
| VIRTUS ADVISERS, LLC | 8,624 | 7,747 | -877 | 0.05 | 0.07 | +0.02 | sell |
| ALPS ADVISORS INC | 54,749 | 50,479 | -4,270 | 0.00 | 0.01 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 2,236,000 | 2,224,000 | -12,000 | 0.31 | 0.44 | +0.12 | sell |
| MYDA Advisors LLC | 80,000 | 25,000 | -55,000 | 0.24 | 0.12 | -0.12 | sell |
| DAFNA Capital Management LLC | 550,784 | 492,684 | -58,100 | 1.56 | 1.70 | +0.14 | sell |
| Rafferty Asset Management, LLC | 232,207 | 151,274 | -80,933 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 691,422 | 541,417 | -150,005 | 0.04 | 0.05 | +0.01 | sell |
| Commodore Capital LP | 1,400,000 | 1,248,062 | -151,938 | 1.49 | 1.57 | +0.08 | sell |
| Artal Group S.A. | 2,018,056 | 1,768,056 | -250,000 | 0.79 | 0.85 | +0.06 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,335,845 | 6,946,230 | -389,615 | 3.62 | 4.52 | +0.90 | sell |
| Affinity Asset Advisors, LLC | 856,535 | 191,535 | -665,000 | 2.20 | 0.50 | -1.69 | sell |
| Prosight Management, LP | 1,932,456 | 950,000 | -982,456 | 5.59 | 5.48 | -0.10 | sell |