| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7,155,417 | 7,934,104 | +778,687 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,658,000 | 5,800,000 | +3,142,000 | 1.36 | 1.17 | -0.18 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,652,782 | 5,076,448 | -2,576,334 | 5.37 | 1.64 | -3.73 | sell |
| VANGUARD GROUP INC | 4,203,687 | 4,818,898 | +615,211 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,451,041 | +4,451,041 | 0.00 | 0.52 | +0.52 | buy |
| EcoR1 Capital, LLC | 5,806,871 | 3,557,269 | -2,249,602 | 3.89 | 1.24 | -2.65 | sell |
| STATE STREET CORP | 2,668,844 | 3,345,462 | +676,618 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,206,714 | 3,274,125 | +2,067,411 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 3,371,761 | 2,567,469 | -804,292 | 1.93 | 0.76 | -1.17 | sell |
| MILLENNIUM MANAGEMENT LLC | 845,194 | 2,367,148 | +1,521,954 | 0.01 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 3,541,505 | 2,250,000 | -1,291,505 | 1.01 | 0.28 | -0.73 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,780,509 | 1,782,044 | +1,535 | 0.00 | 0.00 | -0.00 | buy |
| Foresite Capital Management IV, LLC | 1,849,947 | 1,726,882 | -123,065 | 23.62 | 13.83 | -9.80 | sell |
| FRANKLIN RESOURCES INC | 1,588,401 | 1,538,592 | -49,809 | 0.01 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,053,764 | 1,425,960 | +372,196 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 1,423,642 | 1,423,642 | 0 | 2.36 | 1.21 | -1.15 | hold |
| Siren, L.L.C. | 1,339,942 | 1,339,942 | 0 | 1.31 | 0.52 | -0.79 | hold |
| Prosight Management, LP | 705,109 | 1,325,000 | +619,891 | 3.49 | 3.23 | -0.26 | buy |
| D. E. Shaw & Co., Inc. | 423,208 | 1,151,195 | +727,987 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 103,069 | 1,115,741 | +1,012,672 | 0.00 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,188,995 | 986,951 | -202,044 | 0.02 | 0.01 | -0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 977,920 | +977,920 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 948,905 | +948,905 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 1,052,063 | 905,184 | -146,879 | 0.04 | 0.01 | -0.03 | sell |
| ALGERT GLOBAL LLC | 272,276 | 883,703 | +611,427 | 0.14 | 0.18 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 709,484 | 863,085 | +153,601 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 694,387 | +694,387 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 685,167 | 664,928 | -20,239 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 624,952 | 635,494 | +10,542 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 610,087 | 610,087 | 0 | 1.95 | 0.98 | -0.97 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 106,110 | 597,810 | +491,700 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 58,583 | 566,945 | +508,362 | 0.01 | 0.06 | +0.04 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 553,542 | 558,442 | +4,900 | 7.81 | 4.16 | -3.65 | buy |
| Walleye Capital LLC | 571,365 | 536,318 | -35,047 | 0.12 | 0.04 | -0.07 | sell |
| DAFNA Capital Management LLC | 408,368 | 448,368 | +40,000 | 1.89 | 0.99 | -0.89 | buy |
| Candriam S.C.A. | 906,482 | 422,652 | -483,830 | 0.10 | 0.02 | -0.08 | sell |
| JPMORGAN CHASE & CO | 409,241 | 365,921 | -43,320 | 0.00 | 0.00 | -0.00 | sell |
| 1492 Capital Management LLC | 73,224 | 342,598 | +269,374 | 0.72 | 1.42 | +0.70 | buy |
| BANK OF AMERICA CORP /DE/ | 350,415 | 325,220 | -25,195 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 129,816 | 315,475 | +185,659 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 166,526 | 314,526 | +148,000 | 0.26 | 0.28 | +0.02 | buy |
| Russell Investments Group, Ltd. | 252,770 | 298,662 | +45,892 | 0.01 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 54,971 | 297,234 | +242,263 | 0.01 | 0.03 | +0.02 | buy |
| Voss Capital, LP | 0 | 275,000 | +275,000 | 0.00 | 0.18 | +0.18 | buy |
| TWO SIGMA ADVISERS, LP | 97,999 | 242,200 | +144,201 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 24,940 | 239,933 | +214,993 | 0.01 | 0.04 | +0.03 | buy |
| Holocene Advisors, LP | 2,689,456 | 226,895 | -2,462,561 | 0.21 | 0.01 | -0.21 | sell |
| Bank of New York Mellon Corp | 205,678 | 202,941 | -2,737 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 165,484 | 201,864 | +36,380 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 86,431 | 184,428 | +97,997 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 143,207 | 172,704 | +29,497 | 0.02 | 0.01 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 208,239 | 166,119 | -42,120 | 0.01 | 0.00 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 15,287 | 163,559 | +148,272 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 157,959 | +157,959 | 0.00 | 1.21 | +1.21 | buy |
| Velan Capital Investment Management LP | 0 | 150,000 | +150,000 | 0.00 | 1.13 | +1.13 | buy |
| AQR CAPITAL MANAGEMENT LLC | 122,515 | 149,728 | +27,213 | 0.00 | 0.00 | -0.00 | buy |
| Wealthfront Advisers LLC | 0 | 147,943 | +147,943 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 91,737 | 145,614 | +53,877 | 0.01 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 100,875 | 143,587 | +42,712 | 0.36 | 0.23 | -0.13 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,668 | 131,718 | +9,050 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 130,000 | 130,000 | 0 | 1.47 | 1.12 | -0.35 | hold |
| CITIGROUP INC | 65,010 | 125,914 | +60,904 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 124,169 | 122,915 | -1,254 | 0.11 | 0.05 | -0.06 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 117,334 | +117,334 | 0.00 | 0.08 | +0.08 | buy |
| Verition Fund Management LLC | 88,395 | 115,594 | +27,199 | 0.01 | 0.01 | -0.01 | buy |
| JANE STREET GROUP, LLC | 126,085 | 100,216 | -25,869 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.14 | 0.06 | -0.08 | hold |
| RHUMBLINE ADVISERS | 98,068 | 99,991 | +1,923 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 93,496 | +93,496 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 91,680 | +91,680 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 89,305 | +89,305 | 0.00 | 0.06 | +0.06 | buy |
| Swiss National Bank | 89,300 | 89,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,321 | 84,514 | +60,193 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 80,000 | 80,000 | 0 | 0.11 | 0.05 | -0.06 | hold |
| Aquatic Capital Management LLC | 18,700 | 79,917 | +61,217 | 0.01 | 0.02 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 41,874 | 76,533 | +34,659 | 0.04 | 0.04 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 71,497 | +71,497 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 66,439 | 67,238 | +799 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 33,094 | 66,706 | +33,612 | 0.00 | 0.00 | -0.00 | buy |
| Aaron Wealth Advisors LLC | 67,991 | 65,685 | -2,306 | 0.16 | 0.07 | -0.09 | sell |
| DEUTSCHE BANK AG\ | 43,488 | 64,623 | +21,135 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 0 | 63,866 | +63,866 | 0.00 | 0.07 | +0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 60,847 | 60,847 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 54,090 | 53,980 | -110 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 53,738 | 53,738 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 76,016 | 53,623 | -22,393 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,239 | 51,852 | +46,613 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,257 | 51,167 | +35,910 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 50,949 | +50,949 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 50,039 | +50,039 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 47,295 | 49,371 | +2,076 | 0.04 | 0.02 | -0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,414 | 47,031 | +3,617 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 21,161 | 46,181 | +25,020 | 0.14 | 0.15 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,206 | 44,923 | -283 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 42,052 | 44,828 | +2,776 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 16,163 | 43,085 | +26,922 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 38,805 | +38,805 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,813 | 37,007 | -806 | 0.00 | 0.00 | -0.00 | sell |