| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARMISTICE CAPITAL, LLC | 2,658,000 | 5,800,000 | +3,142,000 | 0.83 | 0.69 | -0.14 | buy |
| Prosight Management, LP | 705,109 | 1,325,000 | +619,891 | 3.39 | 3.19 | -0.20 | buy |
| ALGERT GLOBAL LLC | 272,276 | 883,703 | +611,427 | 0.14 | 0.18 | 0.00 | buy |
| 1492 Capital Management LLC | 73,224 | 342,598 | +269,374 | 0.71 | 1.42 | +0.70 | buy |
| ExodusPoint Capital Management, LP | 54,971 | 297,234 | +242,263 | 0.01 | 0.03 | 0.00 | buy |
| Rhenman & Partners Asset Management AB | 166,526 | 314,526 | +148,000 | 0.26 | 0.28 | +0.02 | buy |
| Rafferty Asset Management, LLC | 91,737 | 145,614 | +53,877 | 0.01 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 100,875 | 143,587 | +42,712 | 0.36 | 0.23 | -0.13 | buy |
| DAFNA Capital Management LLC | 408,368 | 448,368 | +40,000 | 1.89 | 0.99 | -0.89 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 41,874 | 76,533 | +34,659 | 0.04 | 0.04 | +0.00 | buy |
| Woodline Partners LP | 143,207 | 172,704 | +29,497 | 0.02 | 0.01 | -0.01 | buy |
| HighVista Strategies LLC | 21,161 | 46,181 | +25,020 | 0.14 | 0.15 | +0.01 | buy |
| PROFUND ADVISORS LLC | 18,868 | 28,358 | +9,490 | 0.01 | 0.01 | 0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 553,542 | 558,442 | +4,900 | 7.81 | 4.16 | -3.65 | buy |
| VIRTUS ADVISERS, LLC | 4,275 | 7,336 | +3,061 | 0.04 | 0.03 | -0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 47,295 | 49,371 | +2,076 | 0.04 | 0.02 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,739 | 16,489 | +1,750 | 0.03 | 0.01 | -0.02 | buy |
| NorthCrest Asset Manangement, LLC | 10,687 | 10,512 | -175 | 0.01 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 124,169 | 122,915 | -1,254 | 0.11 | 0.05 | -0.06 | sell |
| Aaron Wealth Advisors LLC | 67,991 | 65,685 | -2,306 | 0.16 | 0.07 | -0.09 | sell |
| Foresite Capital Management IV, LLC | 1,849,947 | 1,726,882 | -123,065 | 23.62 | 13.83 | -9.80 | sell |
| Candriam S.C.A. | 906,482 | 422,652 | -483,830 | 0.11 | 0.02 | -0.09 | sell |
| BVF INC/IL | 3,371,761 | 2,567,469 | -804,292 | 1.93 | 0.76 | -1.17 | sell |
| Avoro Capital Advisors LLC | 3,541,505 | 2,250,000 | -1,291,505 | 1.01 | 0.28 | -0.73 | sell |
| EcoR1 Capital, LLC | 5,806,871 | 3,557,269 | -2,249,602 | 3.88 | 1.17 | -2.71 | sell |
| Holocene Advisors, LP | 2,689,456 | 226,895 | -2,462,561 | 0.21 | 0.01 | -0.21 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,652,782 | 5,076,448 | -2,576,334 | 4.78 | 1.51 | -3.28 | sell |