| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,451,041 | +4,451,041 | 0.00 | 0.52 | +0.52 | buy |
| ARMISTICE CAPITAL, LLC | 2,658,000 | 5,800,000 | +3,142,000 | 1.36 | 1.17 | -0.18 | buy |
| MORGAN STANLEY | 1,206,714 | 3,274,125 | +2,067,411 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 845,194 | 2,367,148 | +1,521,954 | 0.01 | 0.02 | +0.00 | buy |
| Qube Research & Technologies Ltd | 103,069 | 1,115,741 | +1,012,672 | 0.00 | 0.02 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 977,920 | +977,920 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 948,905 | +948,905 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 7,155,417 | 7,934,104 | +778,687 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 423,208 | 1,151,195 | +727,987 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 694,387 | +694,387 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,668,844 | 3,345,462 | +676,618 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 705,109 | 1,325,000 | +619,891 | 3.49 | 3.23 | -0.26 | buy |
| VANGUARD GROUP INC | 4,203,687 | 4,818,898 | +615,211 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 272,276 | 883,703 | +611,427 | 0.14 | 0.18 | +0.04 | buy |
| Trexquant Investment LP | 58,583 | 566,945 | +508,362 | 0.01 | 0.06 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 106,110 | 597,810 | +491,700 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,053,764 | 1,425,960 | +372,196 | 0.00 | 0.00 | -0.00 | buy |
| Voss Capital, LP | 0 | 275,000 | +275,000 | 0.00 | 0.18 | +0.18 | buy |
| 1492 Capital Management LLC | 73,224 | 342,598 | +269,374 | 0.72 | 1.42 | +0.70 | buy |
| ExodusPoint Capital Management, LP | 54,971 | 297,234 | +242,263 | 0.01 | 0.03 | +0.02 | buy |
| Jump Financial, LLC | 24,940 | 239,933 | +214,993 | 0.01 | 0.04 | +0.03 | buy |
| UBS Group AG | 129,816 | 315,475 | +185,659 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 157,959 | +157,959 | 0.00 | 1.21 | +1.21 | buy |
| GOLDMAN SACHS GROUP INC | 709,484 | 863,085 | +153,601 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 0 | 150,000 | +150,000 | 0.00 | 1.13 | +1.13 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 15,287 | 163,559 | +148,272 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 166,526 | 314,526 | +148,000 | 0.26 | 0.28 | +0.02 | buy |
| Wealthfront Advisers LLC | 0 | 147,943 | +147,943 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 97,999 | 242,200 | +144,201 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 117,334 | +117,334 | 0.00 | 0.08 | +0.08 | buy |
| FMR LLC | 86,431 | 184,428 | +97,997 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 93,496 | +93,496 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 91,680 | +91,680 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 89,305 | +89,305 | 0.00 | 0.06 | +0.06 | buy |
| JENNISON ASSOCIATES LLC | 0 | 71,497 | +71,497 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 63,866 | +63,866 | 0.00 | 0.07 | +0.07 | buy |
| Aquatic Capital Management LLC | 18,700 | 79,917 | +61,217 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 65,010 | 125,914 | +60,904 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,321 | 84,514 | +60,193 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 91,737 | 145,614 | +53,877 | 0.01 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 50,949 | +50,949 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 50,039 | +50,039 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,239 | 51,852 | +46,613 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 252,770 | 298,662 | +45,892 | 0.01 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 100,875 | 143,587 | +42,712 | 0.36 | 0.23 | -0.13 | buy |
| DAFNA Capital Management LLC | 408,368 | 448,368 | +40,000 | 1.89 | 0.99 | -0.89 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 38,805 | +38,805 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 165,484 | 201,864 | +36,380 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,257 | 51,167 | +35,910 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 41,874 | 76,533 | +34,659 | 0.04 | 0.04 | +0.00 | buy |
| Creative Planning | 0 | 34,166 | +34,166 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 33,094 | 66,706 | +33,612 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 143,207 | 172,704 | +29,497 | 0.02 | 0.01 | -0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 28,748 | +28,748 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 122,515 | 149,728 | +27,213 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 88,395 | 115,594 | +27,199 | 0.01 | 0.01 | -0.01 | buy |
| HSBC HOLDINGS PLC | 16,163 | 43,085 | +26,922 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 21,161 | 46,181 | +25,020 | 0.14 | 0.15 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 43,488 | 64,623 | +21,135 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 20,669 | +20,669 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 20,331 | +20,331 | 0.00 | 0.02 | +0.02 | buy |
| Blueshift Asset Management, LLC | 0 | 20,031 | +20,031 | 0.00 | 0.06 | +0.06 | buy |
| Man Group plc | 0 | 18,705 | +18,705 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 17,538 | +17,538 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 15,912 | +15,912 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 14,926 | +14,926 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 7,769 | 22,104 | +14,335 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 12,490 | +12,490 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,562 | 34,989 | +11,427 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 0 | 11,344 | +11,344 | 0.00 | 0.06 | +0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 624,952 | 635,494 | +10,542 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 10,301 | +10,301 | 0.00 | 0.00 | +0.00 | buy |
| Harbor Advisors LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 18,868 | 28,358 | +9,490 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,668 | 131,718 | +9,050 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,060 | 26,630 | +8,570 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 14,760 | 20,815 | +6,055 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 18,230 | 24,103 | +5,873 | 0.00 | 0.00 | -0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 553,542 | 558,442 | +4,900 | 7.81 | 4.16 | -3.65 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,726 | 28,070 | +4,344 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,414 | 47,031 | +3,617 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,275 | 7,336 | +3,061 | 0.04 | 0.03 | -0.01 | buy |
| MAI Capital Management | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,052 | 44,828 | +2,776 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,464 | 13,749 | +2,285 | 0.00 | 0.00 | -0.00 | buy |
| Riverview Trust Co | 0 | 2,151 | +2,151 | 0.00 | 0.02 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 47,295 | 49,371 | +2,076 | 0.04 | 0.02 | -0.02 | buy |
| RHUMBLINE ADVISERS | 98,068 | 99,991 | +1,923 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,739 | 16,489 | +1,750 | 0.03 | 0.01 | -0.02 | buy |
| CWM, LLC | 1,236 | 2,856 | +1,620 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,780,509 | 1,782,044 | +1,535 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 1,002 | +1,002 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 66,439 | 67,238 | +799 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 668 | +668 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 221 | 772 | +551 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Management Group, LLC | 0 | 243 | +243 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 10 | 188 | +178 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,162 | 13,320 | +158 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |