| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 9,515,135 | 9,010,793 | -504,342 | 0.00 | 0.00 | +0.00 | sell |
| BVF INC/IL | 8,617,162 | 8,617,162 | 0 | 3.09 | 3.01 | -0.08 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,116,000 | 8,575,422 | +459,422 | 2.18 | 2.22 | +0.04 | buy |
| VANGUARD GROUP INC | 5,468,522 | 5,507,627 | +39,105 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 4,672,000 | 4,936,000 | +264,000 | 1.30 | 1.26 | -0.04 | buy |
| STATE STREET CORP | 3,343,131 | 4,931,090 | +1,587,959 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 2,242,192 | 3,062,212 | +820,020 | 0.01 | 0.02 | +0.00 | buy |
| Prosight Management, LP | 2,758,516 | 2,529,600 | -228,916 | 5.86 | 5.43 | -0.43 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,047,926 | 2,028,618 | -19,308 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,224,590 | 2,022,333 | -202,257 | 0.08 | 0.08 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,614,726 | 1,837,264 | -777,462 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 865,310 | 1,830,566 | +965,256 | 0.01 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,093,702 | 1,584,399 | -509,303 | 0.01 | 0.01 | -0.00 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 1,388,794 | 1,422,682 | +33,888 | 7.91 | 7.18 | -0.73 | buy |
| MORGAN STANLEY | 1,813,064 | 1,389,828 | -423,236 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,712,716 | 1,333,523 | -379,193 | 0.02 | 0.02 | -0.00 | sell |
| Assenagon Asset Management S.A. | 1,265,030 | 1,145,016 | -120,014 | 0.02 | 0.02 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 669,046 | 1,117,042 | +447,996 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,139,365 | 1,077,818 | -61,547 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 485,570 | 1,060,025 | +574,455 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 230,880 | 964,880 | +734,000 | 0.20 | 0.79 | +0.59 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,060,829 | 886,579 | -174,250 | 0.02 | 0.02 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 490,000 | 872,000 | +382,000 | 0.48 | 0.85 | +0.37 | buy |
| BANK OF AMERICA CORP /DE/ | 572,175 | 842,128 | +269,953 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 753,600 | 723,217 | -30,383 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 711,896 | 710,882 | -1,014 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 364,932 | 618,571 | +253,639 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 245,822 | 477,145 | +231,323 | 0.00 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 471,993 | +471,993 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 204,725 | 471,794 | +267,069 | 0.00 | 0.01 | +0.00 | buy |
| SECTOR GAMMA AS | 438,415 | 455,841 | +17,426 | 0.96 | 1.08 | +0.12 | buy |
| 1492 Capital Management LLC | 445,640 | 452,638 | +6,998 | 1.60 | 1.80 | +0.21 | buy |
| Pale Fire Capital SE | 607,790 | 452,245 | -155,545 | 0.59 | 0.61 | +0.02 | sell |
| Jump Financial, LLC | 32,794 | 422,443 | +389,649 | 0.00 | 0.06 | +0.05 | buy |
| IEQ CAPITAL, LLC | 274,086 | 398,455 | +124,369 | 0.01 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 376,879 | 394,605 | +17,726 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 343,891 | 392,817 | +48,926 | 0.05 | 0.06 | +0.01 | buy |
| CITADEL ADVISORS LLC | 808,818 | 390,672 | -418,146 | 0.01 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 0 | 390,231 | +390,231 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 327,564 | 346,676 | +19,112 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 86,874 | 306,602 | +219,728 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 245,522 | 295,522 | +50,000 | 0.52 | 0.64 | +0.13 | buy |
| Hennion & Walsh Asset Management, Inc. | 214,850 | 294,805 | +79,955 | 0.07 | 0.11 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 228,444 | 281,115 | +52,671 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 255,240 | 258,427 | +3,187 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 458,264 | 241,539 | -216,725 | 0.01 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 241,095 | +241,095 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 463,368 | 235,868 | -227,500 | 1.01 | 0.57 | -0.44 | sell |
| Trexquant Investment LP | 215,043 | 227,382 | +12,339 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 182,687 | 209,370 | +26,683 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 177,055 | 198,785 | +21,730 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 113,222 | 187,391 | +74,169 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 183,505 | +183,505 | 0.00 | 0.09 | +0.09 | buy |
| SEI INVESTMENTS CO | 0 | 183,448 | +183,448 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 179,728 | +179,728 | 0.00 | 0.35 | +0.35 | buy |
| Russell Investments Group, Ltd. | 327,970 | 160,031 | -167,939 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 118,363 | 156,544 | +38,181 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 126,200 | 152,600 | +26,400 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 48,304 | 151,715 | +103,411 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 399,789 | 151,070 | -248,719 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 145,704 | 145,704 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Swiss National Bank | 134,300 | 145,600 | +11,300 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 93,844 | 134,311 | +40,467 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 124,900 | 133,357 | +8,457 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 62,013 | 125,920 | +63,907 | 0.00 | 0.00 | +0.00 | buy |
| Xcel Wealth Management, LLC | 102,321 | 118,846 | +16,525 | 0.24 | 0.32 | +0.08 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 386,956 | 116,513 | -270,443 | 0.01 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 91,055 | 115,307 | +24,252 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,766 | 106,889 | -3,877 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 119,935 | 104,447 | -15,488 | 0.00 | 0.00 | +0.00 | sell |
| Rangeley Capital, LLC | 120,000 | 102,900 | -17,100 | 1.00 | 0.92 | -0.08 | sell |
| Rosalind Advisors, Inc. | 100,000 | 100,000 | 0 | 0.31 | 0.38 | +0.07 | hold |
| HRT FINANCIAL LP | 368,557 | 98,029 | -270,528 | 0.01 | 0.00 | -0.01 | sell |
| DekaBank Deutsche Girozentrale | 95,000 | 95,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 83,748 | 92,200 | +8,452 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 62,825 | 91,514 | +28,689 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 90,847 | +90,847 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 117,590 | 88,395 | -29,195 | 0.09 | 0.08 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 84,800 | 84,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 78,041 | 80,809 | +2,768 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 78,350 | 78,258 | -92 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,549 | 75,702 | +11,153 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,867 | 72,051 | +6,184 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 38,982 | 71,447 | +32,465 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 24,835 | 69,124 | +44,289 | 0.01 | 0.02 | +0.01 | buy |
| Aaron Wealth Advisors LLC | 67,146 | 67,142 | -4 | 0.04 | 0.04 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 17,085 | 66,870 | +49,785 | 0.04 | 0.19 | +0.15 | buy |
| GROUP ONE TRADING LLC | 76,627 | 65,012 | -11,615 | 0.02 | 0.02 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 64,675 | +64,675 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 395,872 | 54,110 | -341,762 | 2.16 | 0.45 | -1.71 | sell |
| HSBC HOLDINGS PLC | 131,192 | 52,003 | -79,189 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 32,883 | 50,080 | +17,197 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,930 | 48,366 | +5,436 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 32,784 | 46,363 | +13,579 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 46,000 | 46,000 | 0 | 2.31 | 2.47 | +0.16 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,959 | 45,727 | +3,768 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,053 | 45,610 | +5,557 | 0.03 | 0.04 | +0.01 | buy |
| Brevan Howard Capital Management LP | 47,690 | 44,843 | -2,847 | 0.01 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 45,369 | 44,625 | -744 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 44,020 | +44,020 | 0.00 | 0.00 | +0.00 | buy |