| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 11,979,415 | 19,272,991 | +7,293,576 | 2.18 | 5.03 | +2.86 | buy |
| Avoro Capital Advisors LLC | 6,700,000 | 11,700,000 | +5,000,000 | 0.75 | 2.02 | +1.27 | buy |
| MHR FUND MANAGEMENT LLC | 19,997,103 | 23,997,103 | +4,000,000 | 17.76 | 34.36 | +16.60 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 2,965,987 | +2,965,987 | 0.00 | 2.10 | +2.10 | buy |
| Soleus Capital Management, L.P. | 555,000 | 3,505,000 | +2,950,000 | 0.50 | 4.56 | +4.06 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 983,080 | 3,494,184 | +2,511,104 | 0.03 | 0.19 | +0.16 | buy |
| D. E. Shaw & Co., Inc. | 215,134 | 2,352,166 | +2,137,032 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 22,812,820 | 24,915,300 | +2,102,480 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,276,602 | 5,267,864 | +1,991,262 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 2,839,667 | 4,385,694 | +1,546,027 | 0.00 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,313,339 | +1,313,339 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 286,034 | 1,110,997 | +824,963 | 0.00 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 939,546 | 1,616,861 | +677,315 | 0.01 | 0.02 | +0.01 | buy |
| BRAIDWELL LP | 0 | 660,022 | +660,022 | 0.00 | 0.32 | +0.32 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 642,761 | +642,761 | 0.00 | 0.09 | +0.09 | buy |
| Hood River Capital Management LLC | 2,001,510 | 2,624,238 | +622,728 | 0.45 | 0.87 | +0.42 | buy |
| BANK OF AMERICA CORP /DE/ | 936,887 | 1,532,304 | +595,417 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 522,561 | 1,021,067 | +498,506 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,037,098 | 5,506,617 | +469,519 | 0.00 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 310,754 | +310,754 | 0.00 | 0.23 | +0.23 | buy |
| Artisan Partners Limited Partnership | 4,827,670 | 5,138,222 | +310,552 | 0.06 | 0.11 | +0.05 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 278,135 | +278,135 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 257,460 | 505,278 | +247,818 | 0.00 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 224,831 | +224,831 | 0.00 | 0.57 | +0.57 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,598,930 | 1,817,000 | +218,070 | 0.02 | 0.04 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 213,336 | +213,336 | 0.00 | 0.49 | +0.49 | buy |
| TUDOR INVESTMENT CORP ET AL | 33,148 | 244,616 | +211,468 | 0.00 | 0.04 | +0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 182,765 | +182,765 | 0.00 | 0.01 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 0 | 167,959 | +167,959 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,747,023 | 1,913,100 | +166,077 | 0.00 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 55,700 | 218,900 | +163,200 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,021,824 | 1,164,734 | +142,910 | 0.01 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 0 | 140,325 | +140,325 | 0.00 | 0.04 | +0.04 | buy |
| MACQUARIE GROUP LTD | 0 | 122,053 | +122,053 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 286,034 | 407,429 | +121,395 | 0.13 | 0.32 | +0.19 | buy |
| Bayesian Capital Management, LP | 35,400 | 151,700 | +116,300 | 0.03 | 0.21 | +0.18 | buy |
| LPL Financial LLC | 129,136 | 240,677 | +111,541 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 3,681,560 | 3,782,563 | +101,003 | 0.01 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 264,971 | 358,988 | +94,017 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 248,766 | 333,148 | +84,382 | 0.00 | 0.01 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 84,000 | +84,000 | 0.00 | 0.29 | +0.29 | buy |
| LMR Partners LLP | 41,211 | 121,611 | +80,400 | 0.01 | 0.05 | +0.04 | buy |
| SHAKER INVESTMENTS LLC/OH | 0 | 79,087 | +79,087 | 0.00 | 0.50 | +0.50 | buy |
| Man Group plc | 11,619 | 80,583 | +68,964 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 65,792 | +65,792 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 252,890 | 315,440 | +62,550 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 61,225 | +61,225 | 0.00 | 0.07 | +0.07 | buy |
| PRUDENTIAL FINANCIAL INC | 14,895 | 75,563 | +60,668 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 55,010 | +55,010 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 2,182,877 | 2,227,344 | +44,467 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 36,698 | 77,063 | +40,365 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 40,011 | +40,011 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 161,024 | 199,913 | +38,889 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 35,333 | 68,221 | +32,888 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 29,083 | +29,083 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 27,260 | +27,260 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 24,644 | +24,644 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 27,520 | 51,996 | +24,476 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 29,602 | 53,708 | +24,106 | 0.05 | 0.10 | +0.05 | buy |
| Caption Management, LLC | 0 | 23,722 | +23,722 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 368,456 | 391,550 | +23,094 | 0.00 | 0.01 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 22,412 | +22,412 | 0.00 | 0.07 | +0.07 | buy |
| Aquatic Capital Management LLC | 0 | 21,900 | +21,900 | 0.00 | 0.01 | +0.01 | buy |
| FAIRFIELD, BUSH & CO. | 120 | 21,450 | +21,330 | 0.00 | 0.19 | +0.19 | buy |
| Allianz Asset Management GmbH | 0 | 20,800 | +20,800 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 23,100 | 43,878 | +20,778 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 20,077 | +20,077 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 347,728 | 367,787 | +20,059 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 18,510 | +18,510 | 0.00 | 0.06 | +0.06 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 72,733 | 90,267 | +17,534 | 0.11 | 0.17 | +0.06 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 96,618 | 113,952 | +17,334 | 0.00 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 81,981 | 99,145 | +17,164 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 16,931 | +16,931 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 14,757 | 31,557 | +16,800 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 16,625 | +16,625 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 16,250 | +16,250 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 44,145 | 58,753 | +14,608 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 35,468 | 50,024 | +14,556 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 14,163 | +14,163 | 0.00 | 0.00 | +0.00 | buy |
| XML Financial, LLC | 0 | 13,000 | +13,000 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 13,478 | 25,948 | +12,470 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 11,106 | +11,106 | 0.00 | 0.09 | +0.09 | buy |
| Centiva Capital, LP | 0 | 11,030 | +11,030 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 38,324 | 49,163 | +10,839 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 10,272 | +10,272 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 10,250 | +10,250 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 54,319 | 62,210 | +7,891 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 24,411 | 31,368 | +6,957 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 10,462 | 17,026 | +6,564 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 48 | 6,097 | +6,049 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 324,736 | 330,783 | +6,047 | 0.00 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 2,106,792 | 2,112,811 | +6,019 | 1.54 | 3.53 | +1.99 | buy |
| FIDELIS CAPITAL PARTNERS, LLC | 0 | 5,903 | +5,903 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 333,136 | 338,516 | +5,380 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 5,100 | +5,100 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 4,400 | +4,400 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 35,768 | 40,101 | +4,333 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Fund Management Co., Ltd | 0 | 4,208 | +4,208 | 0.00 | 0.01 | +0.01 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 17,919 | 20,906 | +2,987 | 0.00 | 0.00 | +0.00 | buy |