| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 11,979,415 | 19,272,991 | +7,293,576 | 2.17 | 5.00 | +2.82 | buy |
| Avoro Capital Advisors LLC | 6,700,000 | 11,700,000 | +5,000,000 | 0.75 | 2.02 | +1.27 | buy |
| MHR FUND MANAGEMENT LLC | 19,997,103 | 23,997,103 | +4,000,000 | 17.76 | 34.36 | +16.60 | buy |
| Soleus Capital Management, L.P. | 555,000 | 3,505,000 | +2,950,000 | 0.50 | 4.56 | +4.06 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 983,080 | 3,494,184 | +2,511,104 | 0.03 | 0.19 | +0.16 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,276,602 | 5,267,864 | +1,991,262 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 2,001,510 | 2,624,238 | +622,728 | 0.45 | 0.87 | +0.42 | buy |
| Artisan Partners Limited Partnership | 4,827,670 | 5,138,222 | +310,552 | 0.06 | 0.11 | +0.05 | buy |
| TD ASSET MANAGEMENT INC | 257,460 | 505,278 | +247,818 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,021,824 | 1,164,734 | +142,910 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 286,034 | 407,429 | +121,395 | 0.13 | 0.32 | +0.19 | buy |
| Bayesian Capital Management, LP | 35,400 | 151,700 | +116,300 | 0.03 | 0.21 | +0.18 | buy |
| LMR Partners LLP | 41,211 | 121,611 | +80,400 | 0.01 | 0.05 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 29,602 | 53,708 | +24,106 | 0.05 | 0.10 | +0.05 | buy |
| FAIRFIELD, BUSH & CO. | 120 | 21,450 | +21,330 | 0.00 | 0.19 | +0.19 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 72,733 | 90,267 | +17,534 | 0.11 | 0.17 | +0.06 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 96,618 | 113,952 | +17,334 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 324,736 | 330,783 | +6,047 | 0.00 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 2,106,792 | 2,112,811 | +6,019 | 1.54 | 3.53 | +1.99 | buy |
| Rathbones Group PLC | 71,154 | 73,154 | +2,000 | 0.00 | 0.01 | +0.00 | buy |
| Diversified Trust Co | 13,512 | 15,511 | +1,999 | 0.00 | 0.01 | +0.00 | buy |
| Curi Capital, LLC | 70,817 | 72,770 | +1,953 | 0.02 | 0.02 | +0.01 | buy |
| HRT FINANCIAL LP | 294,763 | 296,174 | +1,411 | 0.02 | 0.03 | +0.01 | buy |
| Costello Asset Management, INC | 1,000 | 2,300 | +1,300 | 0.01 | 0.02 | +0.02 | buy |
| Intellectus Partners, LLC | 116,679 | 117,929 | +1,250 | 0.27 | 0.46 | +0.19 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 15,290 | 16,300 | +1,010 | 0.03 | 0.06 | +0.03 | buy |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 36,574 | 37,344 | +770 | 0.03 | 0.06 | +0.02 | buy |
| NFJ INVESTMENT GROUP, LLC | 212,745 | 212,156 | -589 | 0.05 | 0.09 | +0.04 | sell |
| VIRTUS ADVISERS, LLC | 12,008 | 11,237 | -771 | 0.06 | 0.09 | +0.03 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 44,765 | 42,805 | -1,960 | 0.00 | 0.00 | +0.00 | sell |
| GRIMES & COMPANY, INC. | 34,998 | 29,250 | -5,748 | 0.01 | 0.01 | +0.00 | sell |
| Pale Fire Capital SE | 17,024 | 11,000 | -6,024 | 0.02 | 0.02 | +0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 26,603 | 20,052 | -6,551 | 0.01 | 0.01 | +0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 136,183 | 128,984 | -7,199 | 0.01 | 0.02 | +0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 15,290 | 6,600 | -8,690 | 0.03 | 0.02 | -0.01 | sell |
| Bank Pictet & Cie (Europe) AG | 62,963 | 53,890 | -9,073 | 0.02 | 0.02 | +0.01 | sell |
| Pekin Hardy Strauss, Inc. | 53,000 | 43,050 | -9,950 | 0.06 | 0.09 | +0.02 | sell |
| Close Asset Management Ltd | 19,550 | 4,550 | -15,000 | 0.01 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 346,190 | 323,666 | -22,524 | 0.02 | 0.03 | +0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,750,907 | 1,713,825 | -37,082 | 0.82 | 1.45 | +0.63 | sell |
| E Fund Management Co., Ltd. | 66,738 | 27,602 | -39,136 | 0.03 | 0.03 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 91,155 | 50,029 | -41,126 | 0.00 | 0.00 | -0.00 | sell |
| J.W. COLE ADVISORS, INC. | 62,292 | 10,577 | -51,715 | 0.03 | 0.01 | -0.02 | sell |
| ALGERT GLOBAL LLC | 120,088 | 38,778 | -81,310 | 0.04 | 0.02 | -0.02 | sell |
| BANQUE PICTET & CIE SA | 778,038 | 689,356 | -88,682 | 0.05 | 0.10 | +0.04 | sell |
| PROFUND ADVISORS LLC | 202,426 | 93,650 | -108,776 | 0.07 | 0.05 | -0.02 | sell |
| Woodline Partners LP | 1,604,706 | 1,482,859 | -121,847 | 0.14 | 0.20 | +0.06 | sell |
| Arete Wealth Advisors, LLC | 216,250 | 68,500 | -147,750 | 0.13 | 0.09 | -0.04 | sell |
| Rhenman & Partners Asset Management AB | 1,116,818 | 955,000 | -161,818 | 0.91 | 1.34 | +0.43 | sell |
| Parametrica Management Ltd | 320,276 | 131,590 | -188,686 | 4.27 | 2.81 | -1.46 | sell |
| Hudson Bay Capital Management LP | 275,000 | 50,000 | -225,000 | 0.01 | 0.00 | -0.01 | sell |
| C WorldWide Group Holding A/S | 1,360,000 | 1,060,000 | -300,000 | 0.15 | 0.18 | +0.03 | sell |
| Zimmer Partners, LP | 495,000 | 43,500 | -451,500 | 0.15 | 0.01 | -0.13 | sell |
| Brevan Howard Capital Management LP | 692,775 | 233,330 | -459,445 | 0.07 | 0.03 | -0.04 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 500,000 | -500,000 | 0.75 | 0.77 | +0.02 | sell |
| 683 Capital Management, LLC | 1,750,000 | 1,225,000 | -525,000 | 1.17 | 1.33 | +0.16 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 2,636,327 | 2,005,905 | -630,422 | 0.01 | 0.02 | +0.00 | sell |
| Rafferty Asset Management, LLC | 1,247,515 | 584,111 | -663,404 | 0.04 | 0.03 | -0.01 | sell |
| Candriam S.C.A. | 1,727,822 | 1,059,142 | -668,680 | 0.10 | 0.10 | +0.00 | sell |
| Long Focus Capital Management, LLC | 2,135,521 | 1,400,312 | -735,209 | 0.58 | 1.06 | +0.48 | sell |
| Schonfeld Strategic Advisors LLC | 1,021,818 | 244,447 | -777,371 | 0.07 | 0.03 | -0.04 | sell |
| MPM BioImpact LLC | 3,289,470 | 2,200,000 | -1,089,470 | 6.26 | 5.24 | -1.01 | sell |
| DEUTSCHE BANK AG\ | 1,915,412 | 723,666 | -1,191,746 | 0.01 | 0.01 | -0.00 | sell |
| Pictet Asset Management Holding SA | 5,263,309 | 3,250,554 | -2,012,755 | 0.05 | 0.05 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 3,926,159 | 1,200,864 | -2,725,295 | 0.09 | 0.05 | -0.04 | sell |