| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Long Focus Capital Management, LLC | 5,132,000 | 9,250,055 | +4,118,055 | 1.23 | 1.03 | -0.20 | buy |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 1,800,000 | +1,300,000 | 0.24 | 0.33 | +0.09 | buy |
| Soleus Capital Management, L.P. | 6,560,000 | 7,785,000 | +1,225,000 | 3.67 | 2.03 | -1.64 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 3,646,787 | 4,694,122 | +1,047,335 | 0.02 | 0.01 | -0.01 | buy |
| 683 Capital Management, LLC | 1,416,014 | 2,400,000 | +983,986 | 0.65 | 0.55 | -0.10 | buy |
| B Group, Inc. | 992,000 | 1,500,000 | +508,000 | 4.49 | 4.34 | -0.15 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 243,296 | 502,563 | +259,267 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 56,400 | 280,882 | +224,482 | 0.01 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 8,991,573 | 9,216,040 | +224,467 | 0.98 | 0.52 | -0.46 | buy |
| CM Management, LLC | 300,000 | 500,000 | +200,000 | 1.98 | 1.67 | -0.31 | buy |
| Palo Alto Investors LP | 3,041,685 | 3,211,314 | +169,629 | 3.49 | 2.04 | -1.45 | buy |
| Orion Investment Co | 1,060,755 | 1,176,853 | +116,098 | 3.13 | 1.60 | -1.53 | buy |
| Brevan Howard Capital Management LP | 11,962 | 107,615 | +95,653 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 831,059 | 920,461 | +89,402 | 0.01 | 0.00 | -0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 54,630 | 126,940 | +72,310 | 0.08 | 0.08 | +0.00 | buy |
| DnB Asset Management AS | 40,778 | 91,580 | +50,802 | 0.00 | 0.00 | +0.00 | buy |
| Curi Capital, LLC | 108,637 | 157,696 | +49,059 | 0.02 | 0.01 | -0.01 | buy |
| Raiffeisen Bank International AG | 102,000 | 147,000 | +45,000 | 0.01 | 0.01 | -0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 55,000 | 100,000 | +45,000 | 0.10 | 0.10 | -0.00 | buy |
| MACQUARIE GROUP LTD | 4,750,934 | 4,791,235 | +40,301 | 0.04 | 0.02 | -0.02 | buy |
| GRANDFIELD & DODD, LLC | 55,715 | 90,975 | +35,260 | 0.03 | 0.02 | -0.01 | buy |
| MPM BioImpact LLC | 2,673,905 | 2,708,582 | +34,677 | 2.81 | 1.55 | -1.26 | buy |
| Hennion & Walsh Asset Management, Inc. | 335,981 | 366,775 | +30,794 | 0.11 | 0.05 | -0.06 | buy |
| Nebula Research & Development LLC | 71,964 | 94,338 | +22,374 | 0.06 | 0.03 | -0.03 | buy |
| Chicago Partners Investment Group LLC | 20,559 | 40,626 | +20,067 | 0.00 | 0.00 | -0.00 | buy |
| Shay Capital LLC | 25,400 | 42,900 | +17,500 | 0.03 | 0.02 | -0.01 | buy |
| Quarry LP | 10,000 | 23,000 | +13,000 | 0.01 | 0.02 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 23,550 | 35,250 | +11,700 | 0.01 | 0.01 | -0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 30,000 | 40,000 | +10,000 | 0.23 | 0.19 | -0.04 | buy |
| Avantax Planning Partners, Inc. | 23,000 | 29,600 | +6,600 | 0.01 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 38,875 | 42,897 | +4,022 | 0.07 | 0.02 | -0.05 | buy |
| Woodline Partners LP | 563,577 | 566,915 | +3,338 | 0.03 | 0.01 | -0.02 | buy |
| Brookstone Capital Management | 20,583 | 22,927 | +2,344 | 0.00 | 0.00 | -0.00 | buy |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 36,686 | 38,364 | +1,678 | 0.03 | 0.01 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 6,400 | 7,805 | +1,405 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 114,912 | 116,212 | +1,300 | 0.19 | 0.10 | -0.09 | buy |
| China Universal Asset Management Co., Ltd. | 64,625 | 65,766 | +1,141 | 0.04 | 0.02 | -0.02 | buy |
| Beacon Financial Advisory LLC | 20,560 | 21,425 | +865 | 0.05 | 0.02 | -0.03 | buy |
| Capital A Wealth Management, LLC | 50 | 55 | +5 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 39,439 | 39,394 | -45 | 0.01 | 0.01 | -0.01 | sell |
| CIM INVESTMENT MANAGEMENT INC | 31,172 | 30,446 | -726 | 0.07 | 0.02 | -0.04 | sell |
| Legato Capital Management LLC | 18,218 | 17,080 | -1,138 | 0.02 | 0.01 | -0.01 | sell |
| GRIMES & COMPANY, INC. | 33,625 | 32,167 | -1,458 | 0.01 | 0.00 | -0.00 | sell |
| Haven Capital Group, Inc. | 124,449 | 121,911 | -2,538 | 0.87 | 0.45 | -0.42 | sell |
| PROFUND ADVISORS LLC | 107,883 | 88,539 | -19,344 | 0.03 | 0.01 | -0.02 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,594,532 | 1,569,212 | -25,320 | 0.65 | 0.31 | -0.34 | sell |
| Parametrica Management Ltd | 261,090 | 195,878 | -65,212 | 2.55 | 1.10 | -1.46 | sell |
| APIS CAPITAL ADVISORS, LLC | 1,363,000 | 1,277,000 | -86,000 | 6.72 | 2.06 | -4.66 | sell |
| Rafferty Asset Management, LLC | 554,141 | 421,529 | -132,612 | 0.01 | 0.01 | -0.01 | sell |
| Artisan Partners Limited Partnership | 4,542,168 | 4,407,713 | -134,455 | 0.05 | 0.02 | -0.03 | sell |
| BANQUE PICTET & CIE SA | 376,591 | 66,294 | -310,297 | 0.02 | 0.00 | -0.02 | sell |
| Rhenman & Partners Asset Management AB | 1,235,448 | 647,827 | -587,621 | 0.94 | 0.25 | -0.69 | sell |
| T. Rowe Price Investment Management, Inc. | 5,834,456 | 1,930,020 | -3,904,436 | 0.03 | 0.00 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 22,112,266 | 12,711,788 | -9,400,478 | 4.51 | 1.50 | -3.01 | sell |