| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 19,272,991 | 25,933,142 | +6,660,151 | 5.03 | 5.02 | -0.01 | buy |
| Soleus Capital Management, L.P. | 3,505,000 | 7,548,000 | +4,043,000 | 4.56 | 5.34 | +0.78 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,200,864 | 4,540,560 | +3,339,696 | 0.05 | 0.09 | +0.05 | buy |
| Long Focus Capital Management, LLC | 1,400,312 | 4,132,000 | +2,731,688 | 2.40 | 3.43 | +1.03 | buy |
| STATE STREET CORP | 10,402,719 | 12,625,177 | +2,222,458 | 0.01 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 179,850 | 1,994,500 | +1,814,650 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 1,612,055 | +1,612,055 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 24,915,300 | 25,950,644 | +1,035,344 | 0.01 | 0.00 | -0.00 | buy |
| Artal Group S.A. | 0 | 1,011,500 | +1,011,500 | 0.00 | 0.21 | +0.21 | buy |
| BRAIDWELL LP | 660,022 | 1,466,610 | +806,588 | 0.32 | 0.37 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 774,783 | +774,783 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 1,313,339 | 2,050,500 | +737,161 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,532,304 | 2,167,225 | +634,921 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 2,005,905 | 2,536,243 | +530,338 | 0.02 | 0.01 | -0.01 | buy |
| SG Americas Securities, LLC | 53,218 | 498,390 | +445,172 | 0.00 | 0.03 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 330,783 | 769,160 | +438,377 | 0.01 | 0.01 | +0.00 | buy |
| Zimmer Partners, LP | 43,500 | 475,000 | +431,500 | 0.01 | 0.07 | +0.06 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 383,260 | +383,260 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 145,924 | 464,052 | +318,128 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.18 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,506,617 | 5,786,532 | +279,915 | 0.01 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 1,225,000 | 1,500,000 | +275,000 | 1.85 | 1.26 | -0.59 | buy |
| Squarepoint Ops LLC | 0 | 257,543 | +257,543 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 488,038 | 731,607 | +243,569 | 0.26 | 0.18 | -0.07 | buy |
| Neo Ivy Capital Management | 0 | 212,648 | +212,648 | 0.00 | 0.33 | +0.33 | buy |
| Bank of New York Mellon Corp | 834,224 | 1,034,760 | +200,536 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 50,000 | 250,000 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| C WorldWide Group Holding A/S | 1,060,000 | 1,260,000 | +200,000 | 0.18 | 0.11 | -0.07 | buy |
| Quantitative Investment Management, LLC | 0 | 187,508 | +187,508 | 0.00 | 0.16 | +0.16 | buy |
| MPM BioImpact LLC | 2,200,000 | 2,366,714 | +166,714 | 5.24 | 2.95 | -2.29 | buy |
| Qube Research & Technologies Ltd | 55,010 | 200,401 | +145,391 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 584,111 | 724,179 | +140,068 | 0.03 | 0.02 | -0.01 | buy |
| MORGAN STANLEY | 2,691,021 | 2,822,863 | +131,842 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 0 | 131,800 | +131,800 | 0.00 | 0.00 | +0.00 | buy |
| Parametrica Management Ltd | 131,590 | 261,090 | +129,500 | 2.81 | 2.77 | -0.04 | buy |
| WELLS FARGO & COMPANY/MN | 367,787 | 496,396 | +128,609 | 0.00 | 0.00 | -0.00 | buy |
| Baird Financial Group, Inc. | 10,800 | 136,600 | +125,800 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 112,277 | +112,277 | 0.00 | 0.08 | +0.08 | buy |
| Hood River Capital Management LLC | 2,624,238 | 2,732,427 | +108,189 | 0.87 | 0.45 | -0.41 | buy |
| UBS Group AG | 690,880 | 795,204 | +104,324 | 0.00 | 0.00 | -0.00 | buy |
| Edgestream Partners, L.P. | 0 | 99,605 | +99,605 | 0.00 | 0.04 | +0.04 | buy |
| Virtu Financial LLC | 0 | 94,099 | +94,099 | 0.00 | 0.05 | +0.05 | buy |
| Nebula Research & Development LLC | 22,412 | 114,983 | +92,571 | 0.07 | 0.15 | +0.08 | buy |
| Magnetar Financial LLC | 0 | 82,363 | +82,363 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 159,280 | 236,369 | +77,089 | 0.01 | 0.01 | -0.00 | buy |
| HighTower Advisors, LLC | 0 | 76,203 | +76,203 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,913,100 | 1,984,945 | +71,845 | 0.01 | 0.00 | -0.00 | buy |
| Wealthspire Advisors, LLC | 0 | 57,000 | +57,000 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 244,616 | 299,885 | +55,269 | 0.04 | 0.03 | -0.02 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 53,275 | +53,275 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 40,101 | 91,759 | +51,658 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 33,195 | 84,722 | +51,527 | 0.01 | 0.02 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 44,858 | +44,858 | 0.00 | 0.07 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,164,734 | 1,208,867 | +44,133 | 0.02 | 0.01 | -0.01 | buy |
| KETTLE HILL CAPITAL MANAGEMENT, LLC | 0 | 41,906 | +41,906 | 0.00 | 0.08 | +0.08 | buy |
| PANAGORA ASSET MANAGEMENT INC | 323,666 | 361,187 | +37,521 | 0.03 | 0.01 | -0.01 | buy |
| ROYAL BANK OF CANADA | 99,145 | 136,334 | +37,189 | 0.00 | 0.00 | -0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 16,300 | 51,980 | +35,680 | 0.06 | 0.09 | +0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 77,463 | 112,471 | +35,008 | 0.01 | 0.01 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 33,400 | +33,400 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 32,947 | +32,947 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 93,650 | 124,660 | +31,010 | 0.05 | 0.04 | -0.02 | buy |
| Clear Harbor Asset Management, LLC | 0 | 30,800 | +30,800 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 11,237 | 39,069 | +27,832 | 0.09 | 0.15 | +0.06 | buy |
| MetLife Investment Management, LLC | 121,106 | 146,416 | +25,310 | 0.01 | 0.01 | -0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 24,124 | +24,124 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 23,767 | +23,767 | 0.00 | 0.02 | +0.02 | buy |
| TRANSCEND CAPITAL ADVISORS, LLC | 0 | 22,500 | +22,500 | 0.00 | 0.01 | +0.01 | buy |
| SeaCrest Wealth Management, LLC | 0 | 21,683 | +21,683 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 835 | 22,000 | +21,165 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 255,353 | 276,300 | +20,947 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 216 | 20,216 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 18,770 | +18,770 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 5,000 | 22,400 | +17,400 | 0.02 | 0.04 | +0.02 | buy |
| CIM INVESTMENT MANAGEMENT INC | 13,773 | 31,172 | +17,399 | 0.06 | 0.08 | +0.02 | buy |
| Walleye Capital LLC | 0 | 17,330 | +17,330 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 48,311 | 65,451 | +17,140 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 16,939 | +16,939 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 43,878 | 60,012 | +16,134 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 16,067 | +16,067 | 0.00 | 0.01 | +0.01 | buy |
| Blueshift Asset Management, LLC | 0 | 15,831 | +15,831 | 0.00 | 0.04 | +0.04 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 15,000 | 30,000 | +15,000 | 0.06 | 0.09 | +0.02 | buy |
| Beacon Financial Advisory LLC | 0 | 14,800 | +14,800 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 203,744 | 218,504 | +14,760 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 315,440 | 330,032 | +14,592 | 0.00 | 0.00 | -0.00 | buy |
| CHOREO, LLC | 0 | 14,354 | +14,354 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 14,293 | +14,293 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 14,106 | +14,106 | 0.00 | 0.02 | +0.02 | buy |
| Brookstone Capital Management | 0 | 13,935 | +13,935 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 27,602 | 40,912 | +13,310 | 0.03 | 0.02 | -0.01 | buy |
| B. Riley Wealth Advisors, Inc. | 0 | 13,296 | +13,296 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,483 | +11,483 | 0.00 | 0.00 | +0.00 | buy |
| AVANTAX ADVISORY SERVICES, INC. | 0 | 11,409 | +11,409 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 16,931 | 28,022 | +11,091 | 0.00 | 0.00 | -0.00 | buy |
| Bollard Group LLC | 0 | 10,700 | +10,700 | 0.00 | 0.00 | +0.00 | buy |
| Abacus Planning Group, Inc. | 0 | 10,284 | +10,284 | 0.00 | 0.02 | +0.02 | buy |
| Ethic Inc. | 0 | 10,242 | +10,242 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 10,034 | +10,034 | 0.00 | 0.00 | +0.00 | buy |
| Prime Capital Investment Advisors, LLC | 0 | 10,021 | +10,021 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,015 | +10,015 | 0.00 | 0.02 | +0.02 | buy |