| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 19,272,991 | 25,933,142 | +6,660,151 | 5.00 | 5.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 3,505,000 | 7,548,000 | +4,043,000 | 4.56 | 5.34 | +0.78 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,200,864 | 4,540,560 | +3,339,696 | 0.05 | 0.10 | +0.05 | buy |
| Long Focus Capital Management, LLC | 1,400,312 | 4,132,000 | +2,731,688 | 1.06 | 1.27 | +0.21 | buy |
| BRAIDWELL LP | 660,022 | 1,466,610 | +806,588 | 0.32 | 0.37 | +0.05 | buy |
| T. Rowe Price Investment Management, Inc. | 1,313,339 | 2,050,500 | +737,161 | 0.01 | 0.01 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 2,005,905 | 2,536,243 | +530,338 | 0.02 | 0.01 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 330,783 | 769,160 | +438,377 | 0.01 | 0.01 | +0.00 | buy |
| Zimmer Partners, LP | 43,500 | 475,000 | +431,500 | 0.01 | 0.07 | +0.06 | buy |
| 683 Capital Management, LLC | 1,225,000 | 1,500,000 | +275,000 | 1.33 | 0.91 | -0.42 | buy |
| GROUP ONE TRADING LLC | 488,038 | 731,607 | +243,569 | 0.32 | 0.22 | -0.10 | buy |
| Hudson Bay Capital Management LP | 50,000 | 250,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| C WorldWide Group Holding A/S | 1,060,000 | 1,260,000 | +200,000 | 0.18 | 0.11 | -0.07 | buy |
| MPM BioImpact LLC | 2,200,000 | 2,366,714 | +166,714 | 5.24 | 2.95 | -2.29 | buy |
| Rafferty Asset Management, LLC | 584,111 | 724,179 | +140,068 | 0.03 | 0.02 | -0.01 | buy |
| Parametrica Management Ltd | 131,590 | 261,090 | +129,500 | 2.81 | 2.77 | -0.04 | buy |
| Hood River Capital Management LLC | 2,624,238 | 2,732,427 | +108,189 | 0.87 | 0.45 | -0.41 | buy |
| Nebula Research & Development LLC | 22,412 | 114,983 | +92,571 | 0.07 | 0.15 | +0.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 244,616 | 299,885 | +55,269 | 0.05 | 0.03 | -0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,164,734 | 1,208,867 | +44,133 | 0.02 | 0.01 | -0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 323,666 | 361,187 | +37,521 | 0.03 | 0.01 | -0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 16,300 | 51,980 | +35,680 | 0.06 | 0.09 | +0.03 | buy |
| PROFUND ADVISORS LLC | 93,650 | 124,660 | +31,010 | 0.05 | 0.04 | -0.02 | buy |
| VIRTUS ADVISERS, LLC | 11,237 | 39,069 | +27,832 | 0.09 | 0.15 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 5,000 | 22,400 | +17,400 | 0.02 | 0.04 | +0.02 | buy |
| CIM INVESTMENT MANAGEMENT INC | 13,773 | 31,172 | +17,399 | 0.06 | 0.08 | +0.02 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 15,000 | 30,000 | +15,000 | 0.07 | 0.09 | +0.02 | buy |
| E Fund Management Co., Ltd. | 27,602 | 40,912 | +13,310 | 0.03 | 0.02 | -0.01 | buy |
| DnB Asset Management AS | 16,931 | 28,022 | +11,091 | 0.00 | 0.00 | -0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 4,400 | 13,650 | +9,250 | 0.01 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 50,029 | 58,084 | +8,055 | 0.00 | 0.00 | -0.00 | buy |
| GRIMES & COMPANY, INC. | 29,250 | 33,375 | +4,125 | 0.01 | 0.01 | -0.01 | buy |
| Pale Fire Capital SE | 11,000 | 14,700 | +3,700 | 0.02 | 0.01 | -0.01 | buy |
| Palo Alto Investors LP | 2,112,811 | 2,116,403 | +3,592 | 3.53 | 1.97 | -1.56 | buy |
| Diversified Trust Co | 15,511 | 16,980 | +1,469 | 0.01 | 0.00 | -0.00 | buy |
| Dunhill Financial, LLC | 30 | 1,130 | +1,100 | 0.00 | 0.01 | +0.01 | buy |
| XML Financial, LLC | 13,000 | 13,500 | +500 | 0.02 | 0.01 | -0.01 | buy |
| Riggs Asset Managment Co. Inc. | 29 | 374 | +345 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 18,087 | 18,218 | +131 | 0.03 | 0.02 | -0.01 | buy |
| Thrive Capital Management, LLC | 10,000 | 10,050 | +50 | 0.08 | 0.04 | -0.04 | buy |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 37,344 | 37,345 | +1 | 0.06 | 0.03 | -0.03 | buy |
| FAIRFIELD, BUSH & CO. | 21,450 | 21,225 | -225 | 0.19 | 0.10 | -0.09 | sell |
| SHAKER INVESTMENTS LLC/OH | 79,087 | 78,853 | -234 | 0.50 | 0.27 | -0.22 | sell |
| Curi Capital, LLC | 72,770 | 72,520 | -250 | 0.02 | 0.01 | -0.01 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 31,657 | 31,360 | -297 | 0.07 | 0.04 | -0.03 | sell |
| Carnegie Investment Counsel | 27,400 | 27,000 | -400 | 0.01 | 0.01 | -0.01 | sell |
| Costello Asset Management, INC | 2,300 | 300 | -2,000 | 0.02 | 0.00 | -0.02 | sell |
| GREAT LAKES ADVISORS, LLC | 128,984 | 125,503 | -3,481 | 0.02 | 0.01 | -0.01 | sell |
| Intellectus Partners, LLC | 117,929 | 113,929 | -4,000 | 0.46 | 0.25 | -0.21 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 20,052 | 15,295 | -4,757 | 0.01 | 0.00 | -0.00 | sell |
| Arete Wealth Advisors, LLC | 68,500 | 63,400 | -5,100 | 0.09 | 0.04 | -0.05 | sell |
| SATURNA CAPITAL CORP | 25,200 | 19,200 | -6,000 | 0.01 | 0.00 | -0.00 | sell |
| Pekin Hardy Strauss, Inc. | 43,050 | 35,050 | -8,000 | 0.09 | 0.04 | -0.05 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 16,300 | 6,600 | -9,700 | 0.06 | 0.01 | -0.05 | sell |
| Bank Pictet & Cie (Europe) AG | 53,890 | 42,973 | -10,917 | 0.02 | 0.01 | -0.01 | sell |
| NFJ INVESTMENT GROUP, LLC | 212,156 | 198,430 | -13,726 | 0.09 | 0.05 | -0.04 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 42,805 | 27,899 | -14,906 | 0.00 | 0.00 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 689,356 | 668,650 | -20,706 | 0.10 | 0.05 | -0.05 | sell |
| China Universal Asset Management Co., Ltd. | 53,708 | 32,876 | -20,832 | 0.10 | 0.04 | -0.06 | sell |
| Artisan Partners Limited Partnership | 5,138,222 | 5,111,409 | -26,813 | 0.11 | 0.06 | -0.05 | sell |
| Rhenman & Partners Asset Management AB | 955,000 | 920,000 | -35,000 | 1.34 | 0.71 | -0.63 | sell |
| Hennion & Walsh Asset Management, Inc. | 407,429 | 368,152 | -39,277 | 0.32 | 0.15 | -0.17 | sell |
| LMR Partners LLP | 121,611 | 61,211 | -60,400 | 0.05 | 0.01 | -0.04 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,713,825 | 1,636,025 | -77,800 | 1.45 | 0.79 | -0.66 | sell |
| Bayesian Capital Management, LP | 151,700 | 47,200 | -104,500 | 0.21 | 0.04 | -0.17 | sell |
| PFM Health Sciences, LP | 310,754 | 152,795 | -157,959 | 0.22 | 0.06 | -0.16 | sell |
| Brevan Howard Capital Management LP | 233,330 | 23,771 | -209,559 | 0.31 | 0.01 | -0.30 | sell |
| TD ASSET MANAGEMENT INC | 505,278 | 284,878 | -220,400 | 0.01 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 1,059,142 | 500,033 | -559,109 | 0.10 | 0.02 | -0.08 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 3,494,184 | 2,491,659 | -1,002,525 | 0.19 | 0.07 | -0.11 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 2,965,987 | 1,555,408 | -1,410,579 | 1.51 | 0.48 | -1.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,267,864 | 3,482,402 | -1,785,462 | 0.01 | 0.00 | -0.01 | sell |
| Pictet Asset Management Holding SA | 3,250,554 | 920,077 | -2,330,477 | 0.05 | 0.01 | -0.04 | sell |