| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 24,915,300 | 25,950,644 | +1,035,344 | 0.01 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 19,272,991 | 25,933,142 | +6,660,151 | 5.03 | 5.02 | -0.01 | buy |
| MHR FUND MANAGEMENT LLC | 23,997,103 | 23,997,103 | 0 | 34.36 | 23.45 | -10.91 | hold |
| STATE STREET CORP | 10,402,719 | 12,625,177 | +2,222,458 | 0.01 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 11,700,000 | 11,700,000 | 0 | 2.02 | 1.25 | -0.77 | hold |
| Soleus Capital Management, L.P. | 3,505,000 | 7,548,000 | +4,043,000 | 4.56 | 5.34 | +0.78 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,506,617 | 5,786,532 | +279,915 | 0.01 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 5,138,222 | 5,111,409 | -26,813 | 0.11 | 0.06 | -0.05 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,200,864 | 4,540,560 | +3,339,696 | 0.05 | 0.09 | +0.05 | buy |
| Long Focus Capital Management, LLC | 1,400,312 | 4,132,000 | +2,731,688 | 2.40 | 3.43 | +1.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,267,864 | 3,482,402 | -1,785,462 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 4,385,694 | 3,398,110 | -987,584 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,691,021 | 2,822,863 | +131,842 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 2,624,238 | 2,732,427 | +108,189 | 0.87 | 0.45 | -0.41 | buy |
| GOLDMAN SACHS GROUP INC | 3,782,563 | 2,621,784 | -1,160,779 | 0.01 | 0.00 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 2,005,905 | 2,536,243 | +530,338 | 0.02 | 0.01 | -0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 3,494,184 | 2,491,659 | -1,002,525 | 0.19 | 0.07 | -0.11 | sell |
| MPM BioImpact LLC | 2,200,000 | 2,366,714 | +166,714 | 5.24 | 2.95 | -2.29 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,871,498 | 2,265,555 | -605,943 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 1,532,304 | 2,167,225 | +634,921 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 2,227,344 | 2,166,958 | -60,386 | 0.01 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 2,112,811 | 2,116,403 | +3,592 | 3.53 | 1.97 | -1.56 | buy |
| T. Rowe Price Investment Management, Inc. | 1,313,339 | 2,050,500 | +737,161 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 179,850 | 1,994,500 | +1,814,650 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,913,100 | 1,984,945 | +71,845 | 0.01 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,713,825 | 1,636,025 | -77,800 | 1.45 | 0.79 | -0.66 | sell |
| MARSHALL WACE, LLP | 0 | 1,612,055 | +1,612,055 | 0.00 | 0.02 | +0.02 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 2,965,987 | 1,555,408 | -1,410,579 | 2.10 | 0.58 | -1.52 | sell |
| 683 Capital Management, LLC | 1,225,000 | 1,500,000 | +275,000 | 1.85 | 1.26 | -0.59 | buy |
| BRAIDWELL LP | 660,022 | 1,466,610 | +806,588 | 0.32 | 0.37 | +0.05 | buy |
| C WorldWide Group Holding A/S | 1,060,000 | 1,260,000 | +200,000 | 0.18 | 0.11 | -0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,164,734 | 1,208,867 | +44,133 | 0.02 | 0.01 | -0.01 | buy |
| Bank of New York Mellon Corp | 834,224 | 1,034,760 | +200,536 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 1,021,067 | 1,030,312 | +9,245 | 0.02 | 0.01 | -0.01 | buy |
| Artal Group S.A. | 0 | 1,011,500 | +1,011,500 | 0.00 | 0.21 | +0.21 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,817,000 | 991,649 | -825,351 | 0.04 | 0.01 | -0.03 | sell |
| NORGES BANK | 1,091,987 | 942,983 | -149,004 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 3,250,554 | 920,077 | -2,330,477 | 0.05 | 0.01 | -0.04 | sell |
| Rhenman & Partners Asset Management AB | 955,000 | 920,000 | -35,000 | 1.34 | 0.71 | -0.63 | sell |
| Opaleye Management Inc. | 897,000 | 897,000 | 0 | 2.90 | 1.64 | -1.25 | hold |
| UBS Group AG | 690,880 | 795,204 | +104,324 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 774,783 | +774,783 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 330,783 | 769,160 | +438,377 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 488,038 | 731,607 | +243,569 | 0.26 | 0.18 | -0.07 | buy |
| Rafferty Asset Management, LLC | 584,111 | 724,179 | +140,068 | 0.03 | 0.02 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 723,666 | 714,367 | -9,299 | 0.00 | 0.00 | -0.00 | sell |
| QVT Financial LP | 678,564 | 678,564 | 0 | 0.94 | 0.51 | -0.43 | hold |
| BANQUE PICTET & CIE SA | 689,356 | 668,650 | -20,706 | 0.11 | 0.05 | -0.05 | sell |
| D. E. Shaw & Co., Inc. | 2,352,166 | 655,830 | -1,696,336 | 0.04 | 0.01 | -0.04 | sell |
| Candriam S.C.A. | 1,059,142 | 500,033 | -559,109 | 0.10 | 0.02 | -0.08 | sell |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.77 | 0.41 | -0.36 | hold |
| SG Americas Securities, LLC | 53,218 | 498,390 | +445,172 | 0.00 | 0.03 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 367,787 | 496,396 | +128,609 | 0.00 | 0.00 | -0.00 | buy |
| Zimmer Partners, LP | 43,500 | 475,000 | +431,500 | 0.01 | 0.07 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 145,924 | 464,052 | +318,128 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 378,956 | 384,456 | +5,500 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 383,260 | +383,260 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 391,550 | 368,800 | -22,750 | 0.01 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 407,429 | 368,152 | -39,277 | 0.32 | 0.15 | -0.17 | sell |
| PANAGORA ASSET MANAGEMENT INC | 323,666 | 361,187 | +37,521 | 0.03 | 0.01 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 358,988 | 335,513 | -23,475 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 315,440 | 330,032 | +14,592 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.18 | +0.18 | buy |
| TUDOR INVESTMENT CORP ET AL | 244,616 | 299,885 | +55,269 | 0.04 | 0.03 | -0.02 | buy |
| TD ASSET MANAGEMENT INC | 505,278 | 284,878 | -220,400 | 0.01 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 333,148 | 284,761 | -48,387 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 255,353 | 276,300 | +20,947 | 0.00 | 0.00 | -0.00 | buy |
| Parametrica Management Ltd | 131,590 | 261,090 | +129,500 | 2.81 | 2.77 | -0.04 | buy |
| Squarepoint Ops LLC | 0 | 257,543 | +257,543 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 50,000 | 250,000 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| CM Management, LLC | 250,000 | 250,000 | 0 | 3.11 | 1.84 | -1.27 | hold |
| LPL Financial LLC | 240,677 | 243,839 | +3,162 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,110,997 | 243,258 | -867,739 | 0.02 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 159,280 | 236,369 | +77,089 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 203,744 | 218,504 | +14,760 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 216,798 | 214,069 | -2,729 | 0.00 | 0.00 | -0.00 | sell |
| Neo Ivy Capital Management | 0 | 212,648 | +212,648 | 0.00 | 0.33 | +0.33 | buy |
| AMERICAN CENTURY COMPANIES INC | 338,516 | 203,038 | -135,478 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 55,010 | 200,401 | +145,391 | 0.00 | 0.00 | +0.00 | buy |
| NFJ INVESTMENT GROUP, LLC | 212,156 | 198,430 | -13,726 | 0.09 | 0.05 | -0.04 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 196,461 | 195,180 | -1,281 | 0.00 | 0.00 | -0.00 | sell |
| Quantitative Investment Management, LLC | 0 | 187,508 | +187,508 | 0.00 | 0.16 | +0.16 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 199,913 | 172,885 | -27,028 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,616,861 | 166,149 | -1,450,712 | 0.02 | 0.00 | -0.02 | sell |
| STIFEL FINANCIAL CORP | 258,295 | 164,320 | -93,975 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 310,754 | 152,795 | -157,959 | 0.23 | 0.07 | -0.16 | sell |
| MetLife Investment Management, LLC | 121,106 | 146,416 | +25,310 | 0.01 | 0.01 | -0.01 | buy |
| CITIGROUP INC | 539,895 | 138,182 | -401,713 | 0.01 | 0.00 | -0.01 | sell |
| Baird Financial Group, Inc. | 10,800 | 136,600 | +125,800 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 99,145 | 136,334 | +37,189 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 0 | 131,800 | +131,800 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 128,984 | 125,503 | -3,481 | 0.02 | 0.01 | -0.01 | sell |
| PROFUND ADVISORS LLC | 93,650 | 124,660 | +31,010 | 0.05 | 0.04 | -0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 110,219 | 117,418 | +7,199 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 22,412 | 114,983 | +92,571 | 0.07 | 0.15 | +0.08 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 113,952 | 113,952 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Intellectus Partners, LLC | 117,929 | 113,929 | -4,000 | 0.46 | 0.25 | -0.21 | sell |
| GUGGENHEIM CAPITAL LLC | 77,463 | 112,471 | +35,008 | 0.01 | 0.01 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 112,277 | +112,277 | 0.00 | 0.08 | +0.08 | buy |
| DekaBank Deutsche Girozentrale | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |