| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MHR FUND MANAGEMENT LLC | 11,997,103 | 19,997,103 | +8,000,000 | 11.88 | 11.15 | -0.72 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,539,807 | 4,476,836 | +2,937,029 | 0.03 | 0.06 | +0.03 | buy |
| Candriam S.C.A. | 1,727,816 | 2,747,853 | +1,020,037 | 0.09 | 0.09 | +0.00 | buy |
| 683 Capital Management, LLC | 1,400,000 | 2,050,000 | +650,000 | 0.96 | 0.95 | -0.01 | buy |
| Artisan Partners Limited Partnership | 4,426,741 | 5,036,479 | +609,738 | 0.05 | 0.04 | -0.01 | buy |
| Long Focus Capital Management, LLC | 1,876,814 | 2,470,521 | +593,707 | 2.00 | 1.61 | -0.39 | buy |
| Rafferty Asset Management, LLC | 1,052,921 | 1,496,170 | +443,249 | 0.04 | 0.04 | -0.00 | buy |
| MPM BioImpact LLC | 2,950,118 | 3,287,397 | +337,279 | 4.18 | 3.99 | -0.19 | buy |
| Opaleye Management Inc. | 421,000 | 610,000 | +189,000 | 0.71 | 0.90 | +0.19 | buy |
| Hudson Bay Capital Management LP | 275,000 | 430,200 | +155,200 | 0.02 | 0.02 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 225,909 | 344,042 | +118,133 | 0.04 | 0.04 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 850,000 | 950,000 | +100,000 | 0.63 | 0.47 | -0.16 | buy |
| BANQUE PICTET & CIE SA | 534,158 | 633,794 | +99,636 | 0.03 | 0.03 | +0.00 | buy |
| Brevan Howard Capital Management LP | 1,481,435 | 1,562,686 | +81,251 | 1.92 | 2.11 | +0.19 | buy |
| PROFUND ADVISORS LLC | 191,083 | 250,510 | +59,427 | 0.07 | 0.06 | -0.01 | buy |
| Capula Management Ltd | 81,520 | 140,060 | +58,540 | 0.07 | 0.04 | -0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 289,384 | 241,974 | +47,410 | 0.08 | 0.03 | 0.00 | sell |
| ALGERT GLOBAL LLC | 352,306 | 393,776 | +41,470 | 0.11 | 0.08 | -0.02 | buy |
| Curi Capital, LLC | 34,791 | 69,817 | +35,026 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 56,609 | 76,850 | +20,241 | 0.03 | 0.03 | -0.00 | buy |
| Arete Wealth Advisors, LLC | 12,900 | 33,000 | +20,100 | 0.01 | 0.03 | +0.02 | buy |
| DUALITY ADVISERS, LP | 24,421 | 44,367 | +19,946 | 0.02 | 0.02 | +0.00 | buy |
| Hood River Capital Management LLC | 1,975,551 | 1,992,335 | +16,784 | 0.41 | 0.29 | -0.12 | buy |
| Carnegie Investment Counsel | 12,400 | 23,400 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 56,341 | 64,863 | +8,522 | 0.08 | 0.06 | -0.02 | buy |
| Bank Pictet & Cie (Europe) AG | 35,819 | 43,724 | +7,905 | 0.01 | 0.01 | -0.00 | buy |
| SATURNA CAPITAL CORP | 20,200 | 26,200 | +6,000 | 0.00 | 0.00 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 12,871 | 17,871 | +5,000 | 0.00 | 0.00 | -0.00 | buy |
| Carlson Capital, L.P. | 104,474 | 108,280 | +3,806 | 0.06 | 0.04 | -0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 16,080 | 19,857 | +3,777 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,942 | 6,356 | +3,414 | 0.01 | 0.01 | +0.00 | buy |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 35,425 | 35,996 | +571 | 0.03 | 0.02 | -0.01 | buy |
| Intellectus Partners, LLC | 120,029 | 120,279 | +250 | 0.25 | 0.17 | -0.08 | buy |
| Diversified Trust Co | 11,853 | 12,031 | +178 | 0.00 | 0.00 | -0.00 | buy |
| Bogart Wealth, LLC | 555 | 485 | -70 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 32,164 | 31,714 | -450 | 0.04 | 0.03 | -0.01 | sell |
| GRIMES & COMPANY, INC. | 15,233 | 14,771 | -462 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 181,531 | 180,495 | -1,036 | 0.08 | 0.05 | -0.02 | sell |
| Parametrica Management Ltd | 96,500 | 95,400 | -1,100 | 1.31 | 0.73 | -0.58 | sell |
| VIRTUS ADVISERS, LLC | 12,542 | 11,405 | -1,137 | 0.05 | 0.03 | -0.02 | sell |
| Vontobel Holding Ltd. | 142,298 | 139,014 | -3,284 | 0.01 | 0.01 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 284,181 | 276,534 | -7,647 | 0.02 | 0.01 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,758,759 | 1,722,711 | -36,048 | 0.70 | 0.50 | -0.20 | sell |
| PANAGORA ASSET MANAGEMENT INC | 390,094 | 333,974 | -56,120 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,663,373 | 3,597,120 | -66,253 | 0.00 | 0.00 | -0.00 | sell |
| Bayesian Capital Management, LP | 83,420 | 14,400 | -69,020 | 0.06 | 0.01 | -0.06 | sell |
| Dynamic Technology Lab Private Ltd | 113,329 | 26,791 | -86,538 | 0.10 | 0.01 | -0.09 | sell |
| Polar Asset Management Partners Inc. | 396,700 | 223,900 | -172,800 | 0.06 | 0.02 | -0.03 | sell |
| PERCEPTIVE ADVISORS LLC | 14,036,410 | 11,962,938 | -2,073,472 | 2.87 | 1.83 | -1.04 | sell |
| Point72 Asset Management, L.P. | 7,786,985 | 1,412,550 | -6,374,435 | 0.19 | 0.02 | -0.17 | sell |