| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hood River Capital Management LLC | 2,732,427 | 8,144,637 | +5,412,210 | 0.45 | 1.23 | +0.78 | buy |
| T. Rowe Price Investment Management, Inc. | 2,050,500 | 5,861,279 | +3,810,779 | 0.01 | 0.03 | +0.02 | buy |
| MACQUARIE GROUP LTD | 0 | 3,190,036 | +3,190,036 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 2,621,784 | 4,390,032 | +1,768,248 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 2,536,243 | 4,033,184 | +1,496,941 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 25,950,644 | 27,313,967 | +1,363,323 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 7,548,000 | 8,528,500 | +980,500 | 5.34 | 6.66 | +1.32 | buy |
| Palo Alto Investors LP | 2,116,403 | 3,041,685 | +925,282 | 1.97 | 3.71 | +1.74 | buy |
| Cutter Capital Management, LP | 0 | 876,009 | +876,009 | 0.00 | 2.43 | +2.43 | buy |
| CITADEL ADVISORS LLC | 243,258 | 1,023,836 | +780,578 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 25,933,142 | 26,617,709 | +684,567 | 5.02 | 5.36 | +0.34 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 675,000 | +675,000 | 0.00 | 4.41 | +4.41 | buy |
| STATE STREET CORP | 12,625,177 | 13,201,978 | +576,801 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 0 | 562,435 | +562,435 | 0.00 | 0.04 | +0.04 | buy |
| GROUP ONE TRADING LLC | 731,607 | 1,282,968 | +551,361 | 0.18 | 0.48 | +0.29 | buy |
| AMERIPRISE FINANCIAL INC | 27,999 | 557,534 | +529,535 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 991,649 | 1,413,917 | +422,268 | 0.01 | 0.02 | +0.01 | buy |
| Long Focus Capital Management, LLC | 4,132,000 | 4,532,000 | +400,000 | 3.43 | 3.76 | +0.34 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 395,447 | +395,447 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 276,300 | 604,584 | +328,284 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 330,032 | 631,130 | +301,098 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,167,225 | 2,450,838 | +283,613 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 284,761 | 469,516 | +184,755 | 0.00 | 0.01 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 147,000 | +147,000 | 0.00 | 0.34 | +0.34 | buy |
| Bayesian Capital Management, LP | 47,200 | 184,400 | +137,200 | 0.04 | 0.20 | +0.16 | buy |
| Rhenman & Partners Asset Management AB | 920,000 | 1,052,500 | +132,500 | 0.71 | 0.80 | +0.09 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 28,893 | 144,280 | +115,387 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 113,777 | +113,777 | 0.00 | 0.03 | +0.03 | buy |
| Orion Investment Co | 794,700 | 906,285 | +111,585 | 2.54 | 3.31 | +0.77 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 97,958 | +97,958 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 284,878 | 369,278 | +84,400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 2,166,958 | 2,248,576 | +81,618 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 496,396 | 575,844 | +79,448 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 136,334 | 209,164 | +72,830 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 84,722 | 155,572 | +70,850 | 0.02 | 0.05 | +0.03 | buy |
| CITIGROUP INC | 138,182 | 208,764 | +70,582 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 65,525 | +65,525 | 0.00 | 0.06 | +0.06 | buy |
| Gotham Asset Management, LLC | 0 | 61,009 | +61,009 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 164,320 | 223,107 | +58,787 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 136,600 | 193,845 | +57,245 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 53,275 | 109,325 | +56,050 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 257,543 | 307,384 | +49,841 | 0.01 | 0.01 | +0.00 | buy |
| NOMURA HOLDINGS INC | 14,175 | 61,689 | +47,514 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,636,025 | 1,679,157 | +43,132 | 0.79 | 0.85 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 714,367 | 755,481 | +41,114 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,366,714 | 2,406,714 | +40,000 | 2.95 | 3.39 | +0.44 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 24,124 | 61,759 | +37,635 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 46,136 | 82,662 | +36,526 | 0.00 | 0.00 | +0.00 | buy |
| Curi Capital, LLC | 72,520 | 108,637 | +36,117 | 0.01 | 0.02 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 35,200 | +35,200 | 0.00 | 0.01 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 383,260 | 414,673 | +31,413 | 0.03 | 0.04 | +0.01 | buy |
| GRANDFIELD & DODD, LLC | 0 | 30,070 | +30,070 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 25,824 | +25,824 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 32,876 | 58,376 | +25,500 | 0.04 | 0.06 | +0.02 | buy |
| CAPTRUST FINANCIAL ADVISORS | 25,435 | 49,606 | +24,171 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 23,679 | +23,679 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 14,700 | 37,375 | +22,675 | 0.01 | 0.06 | +0.04 | buy |
| SHAKER INVESTMENTS LLC/OH | 78,853 | 100,712 | +21,859 | 0.27 | 0.39 | +0.12 | buy |
| SkyView Investment Advisors, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 35,286 | 54,070 | +18,784 | 0.01 | 0.01 | +0.00 | buy |
| HUB Investment Partners, LLC | 0 | 18,686 | +18,686 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 145,760 | 164,316 | +18,556 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 17,900 | +17,900 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 33,995 | 51,720 | +17,725 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 17,484 | +17,484 | 0.00 | 0.03 | +0.03 | buy |
| ProShare Advisors LLC | 49,061 | 65,779 | +16,718 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 16,625 | +16,625 | 0.00 | 0.01 | +0.01 | buy |
| nVerses Capital, LLC | 0 | 15,800 | +15,800 | 0.00 | 0.07 | +0.07 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 15,071 | +15,071 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 12,854 | +12,854 | 0.00 | 0.01 | +0.01 | buy |
| Teza Capital Management LLC | 0 | 12,272 | +12,272 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 117,418 | 129,482 | +12,064 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 63,300 | 74,800 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,208,867 | 1,220,257 | +11,390 | 0.01 | 0.02 | +0.00 | buy |
| Brevan Howard Capital Management LP | 23,771 | 34,121 | +10,350 | 0.01 | 0.02 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 10,040 | +10,040 | 0.00 | 0.02 | +0.02 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 30,000 | 40,000 | +10,000 | 0.09 | 0.13 | +0.05 | buy |
| Farther Finance Advisors, LLC | 6,352 | 15,389 | +9,037 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 91,759 | 100,229 | +8,470 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 13,650 | 21,740 | +8,090 | 0.01 | 0.02 | +0.01 | buy |
| CHOREO, LLC | 14,354 | 21,820 | +7,466 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Financial Advisory LLC | 14,800 | 21,120 | +6,320 | 0.04 | 0.07 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 42,928 | 49,130 | +6,202 | 0.00 | 0.00 | +0.00 | buy |
| Brookstone Capital Management | 13,935 | 20,055 | +6,120 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 22,085 | 27,847 | +5,762 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 36,334 | 41,869 | +5,535 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 14,293 | 18,940 | +4,647 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 32,329 | 36,644 | +4,315 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 24,336 | 28,591 | +4,255 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 8,686 | 12,853 | +4,167 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 124,660 | 128,804 | +4,144 | 0.04 | 0.05 | +0.01 | buy |
| DnB Asset Management AS | 28,022 | 31,941 | +3,919 | 0.00 | 0.00 | +0.00 | buy |
| AVANTAX ADVISORY SERVICES, INC. | 11,409 | 15,159 | +3,750 | 0.00 | 0.00 | +0.00 | buy |
| Keystone Financial Group | 0 | 3,617 | +3,617 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 25,793 | 29,377 | +3,584 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 214,069 | 216,961 | +2,892 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 8,354 | 10,978 | +2,624 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 13,405 | 15,401 | +1,996 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 71,593 | 73,489 | +1,896 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 14,163 | 15,947 | +1,784 | 0.00 | 0.00 | +0.00 | buy |