| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hood River Capital Management LLC | 2,732,427 | 8,144,637 | +5,412,210 | 0.45 | 1.23 | +0.78 | buy |
| T. Rowe Price Investment Management, Inc. | 2,050,500 | 5,861,279 | +3,810,779 | 0.01 | 0.03 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 2,536,243 | 4,033,184 | +1,496,941 | 0.01 | 0.02 | 0.00 | buy |
| Soleus Capital Management, L.P. | 7,548,000 | 8,528,500 | +980,500 | 5.34 | 6.20 | +0.86 | buy |
| Palo Alto Investors LP | 2,116,403 | 3,041,685 | +925,282 | 1.97 | 3.71 | +1.74 | buy |
| PERCEPTIVE ADVISORS LLC | 25,933,142 | 26,617,709 | +684,567 | 5.01 | 5.29 | +0.28 | buy |
| GROUP ONE TRADING LLC | 731,607 | 1,282,968 | +551,361 | 0.22 | 0.71 | +0.48 | buy |
| Long Focus Capital Management, LLC | 4,132,000 | 4,532,000 | +400,000 | 1.27 | 1.49 | +0.22 | buy |
| Bayesian Capital Management, LP | 47,200 | 184,400 | +137,200 | 0.04 | 0.20 | +0.16 | buy |
| Rhenman & Partners Asset Management AB | 920,000 | 1,052,500 | +132,500 | 0.71 | 0.80 | +0.09 | buy |
| Orion Investment Co | 794,700 | 906,285 | +111,585 | 2.54 | 3.31 | +0.77 | buy |
| TD ASSET MANAGEMENT INC | 284,878 | 369,278 | +84,400 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 53,275 | 109,325 | +56,050 | 0.01 | 0.02 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,636,025 | 1,679,157 | +43,132 | 0.79 | 0.85 | +0.07 | buy |
| MPM BioImpact LLC | 2,366,714 | 2,406,714 | +40,000 | 2.95 | 3.39 | +0.44 | buy |
| Curi Capital, LLC | 72,520 | 108,637 | +36,117 | 0.01 | 0.02 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,713,825 | 1,679,157 | +34,668 | 1.45 | 0.85 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 32,876 | 58,376 | +25,500 | 0.04 | 0.06 | +0.02 | buy |
| Pale Fire Capital SE | 14,700 | 37,375 | +22,675 | 0.01 | 0.06 | +0.04 | buy |
| SHAKER INVESTMENTS LLC/OH | 78,853 | 100,712 | +21,859 | 0.27 | 0.39 | +0.12 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,208,867 | 1,220,257 | +11,390 | 0.01 | 0.02 | +0.00 | buy |
| Brevan Howard Capital Management LP | 23,771 | 34,121 | +10,350 | 0.01 | 0.02 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 30,000 | 40,000 | +10,000 | 0.09 | 0.13 | +0.05 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 13,650 | 21,740 | +8,090 | 0.01 | 0.02 | +0.01 | buy |
| Beacon Financial Advisory LLC | 14,800 | 21,120 | +6,320 | 0.04 | 0.07 | +0.02 | buy |
| Brookstone Capital Management | 13,935 | 20,055 | +6,120 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 124,660 | 128,804 | +4,144 | 0.04 | 0.05 | +0.01 | buy |
| DnB Asset Management AS | 28,022 | 31,941 | +3,919 | 0.00 | 0.00 | +0.00 | buy |
| SATURNA CAPITAL CORP | 19,200 | 20,553 | +1,353 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 40,912 | 41,952 | +1,040 | 0.02 | 0.02 | +0.00 | buy |
| XML Financial, LLC | 13,500 | 14,500 | +1,000 | 0.01 | 0.01 | +0.00 | buy |
| GRIMES & COMPANY, INC. | 33,375 | 33,625 | +250 | 0.01 | 0.01 | +0.00 | buy |
| Clearstead Advisors, LLC | 20,216 | 20,330 | +114 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 7,229 | 7,284 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Dunhill Financial, LLC | 1,130 | 1,100 | -30 | 0.01 | 0.01 | -0.00 | sell |
| TRANSCEND CAPITAL ADVISORS, LLC | 22,500 | 21,900 | -600 | 0.01 | 0.01 | +0.00 | sell |
| Intellectus Partners, LLC | 113,929 | 113,329 | -600 | 0.25 | 0.27 | +0.02 | sell |
| SeaCrest Wealth Management, LLC | 21,683 | 20,406 | -1,277 | 0.02 | 0.02 | +0.00 | sell |
| Pekin Hardy Strauss, Inc. | 35,050 | 33,050 | -2,000 | 0.04 | 0.04 | +0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 27,899 | 25,492 | -2,407 | 0.00 | 0.00 | -0.00 | sell |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 2,900 | 240 | -2,660 | 0.00 | 0.00 | +0.00 | sell |
| Wealthspire Advisors, LLC | 57,000 | 53,705 | -3,295 | 0.01 | 0.01 | -0.00 | sell |
| FAIRFIELD, BUSH & CO. | 21,225 | 14,575 | -6,650 | 0.10 | 0.08 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 22,400 | 15,700 | -6,700 | 0.04 | 0.02 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 51,980 | 44,180 | -7,800 | 0.09 | 0.09 | -0.00 | sell |
| NFJ INVESTMENT GROUP, LLC | 198,430 | 189,655 | -8,775 | 0.05 | 0.05 | +0.00 | sell |
| Clear Harbor Asset Management, LLC | 30,800 | 17,550 | -13,250 | 0.02 | 0.01 | -0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 125,503 | 112,080 | -13,423 | 0.01 | 0.01 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 368,152 | 351,449 | -16,703 | 0.15 | 0.15 | +0.00 | sell |
| Pictet Asset Management Holding SA | 920,077 | 902,268 | -17,809 | 0.01 | 0.01 | +0.00 | sell |
| LMR Partners LLP | 61,211 | 41,211 | -20,000 | 0.01 | 0.01 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 44,858 | 24,761 | -20,097 | 0.07 | 0.03 | -0.04 | sell |
| PFM Health Sciences, LP | 152,795 | 132,152 | -20,643 | 0.06 | 0.07 | +0.01 | sell |
| Bank Pictet & Cie (Europe) AG | 42,973 | 19,368 | -23,605 | 0.01 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 114,983 | 89,790 | -25,193 | 0.15 | 0.10 | -0.05 | sell |
| Arete Wealth Advisors, LLC | 63,400 | 34,600 | -28,800 | 0.04 | 0.03 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,994,500 | 1,946,842 | -47,658 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 4,540,560 | 4,472,576 | -67,984 | 0.10 | 0.12 | +0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 361,187 | 292,095 | -69,092 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 724,179 | 652,966 | -71,213 | 0.02 | 0.02 | -0.00 | sell |
| 683 Capital Management, LLC | 1,500,000 | 1,400,000 | -100,000 | 0.91 | 1.00 | +0.09 | sell |
| Hudson Bay Capital Management LP | 250,000 | 135,000 | -115,000 | 0.01 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 5,111,409 | 4,803,825 | -307,584 | 0.06 | 0.07 | +0.01 | sell |
| BANQUE PICTET & CIE SA | 668,650 | 321,759 | -346,891 | 0.05 | 0.02 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,482,402 | 3,102,912 | -379,490 | 0.00 | 0.00 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 769,160 | 243,296 | -525,864 | 0.01 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 1,466,610 | 217,928 | -1,248,682 | 0.37 | 0.06 | -0.31 | sell |
| Avoro Capital Advisors LLC | 11,700,000 | 4,240,000 | -7,460,000 | 1.25 | 0.58 | -0.67 | sell |