| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 646,295 | 1,604,706 | +958,411 | 0.03 | 0.14 | +0.11 | buy |
| Opaleye Management Inc. | 610,000 | 897,000 | +287,000 | 0.90 | 1.94 | +1.04 | buy |
| Parametrica Management Ltd | 95,400 | 320,276 | +224,876 | 0.73 | 4.27 | +3.54 | buy |
| Arete Wealth Advisors, LLC | 33,000 | 216,250 | +183,250 | 0.03 | 0.13 | +0.11 | buy |
| Rhenman & Partners Asset Management AB | 950,000 | 1,116,818 | +166,818 | 0.47 | 0.91 | +0.44 | buy |
| BANQUE PICTET & CIE SA | 633,794 | 778,038 | +144,244 | 0.03 | 0.05 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 241,974 | 104,059 | +137,915 | 0.03 | 0.06 | 0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 180,495 | 286,034 | +105,539 | 0.05 | 0.13 | +0.08 | buy |
| CM Management, LLC | 200,000 | 250,000 | +50,000 | 0.97 | 1.63 | +0.67 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,722,711 | 1,750,907 | +28,196 | 0.50 | 0.82 | +0.33 | buy |
| China Universal Asset Management Co., Ltd. | 6,356 | 29,602 | +23,246 | 0.01 | 0.05 | +0.04 | buy |
| Bayesian Capital Management, LP | 14,400 | 35,400 | +21,000 | 0.01 | 0.03 | +0.02 | buy |
| GRIMES & COMPANY, INC. | 14,771 | 34,998 | +20,227 | 0.00 | 0.01 | +0.01 | buy |
| Bank Pictet & Cie (Europe) AG | 43,724 | 62,963 | +19,239 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 11,962,938 | 11,979,415 | +16,477 | 1.82 | 2.17 | +0.36 | buy |
| PANAGORA ASSET MANAGEMENT INC | 333,974 | 346,190 | +12,216 | 0.01 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 1,992,335 | 2,001,510 | +9,175 | 0.29 | 0.45 | +0.16 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 64,863 | 72,733 | +7,870 | 0.06 | 0.11 | +0.05 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,758,759 | 1,750,907 | +7,852 | 0.70 | 0.82 | 0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 19,857 | 26,603 | +6,746 | 0.00 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 16,079 | 22,712 | +6,633 | 0.02 | 0.05 | +0.03 | buy |
| Carnegie Investment Counsel | 23,400 | 27,400 | +4,000 | 0.00 | 0.01 | +0.00 | buy |
| Belvedere Trading LLC | 589 | 4,323 | +3,734 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 17,871 | 20,559 | +2,688 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 3,287,397 | 3,289,470 | +2,073 | 3.99 | 6.26 | +2.26 | buy |
| Pale Fire Capital SE | 15,100 | 17,024 | +1,924 | 0.01 | 0.02 | +0.01 | buy |
| Diversified Trust Co | 12,031 | 13,512 | +1,481 | 0.00 | 0.00 | +0.00 | buy |
| Curi Capital, LLC | 69,817 | 70,817 | +1,000 | 0.01 | 0.02 | +0.01 | buy |
| Legato Capital Management LLC | 17,445 | 18,087 | +642 | 0.01 | 0.02 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 11,405 | 12,008 | +603 | 0.03 | 0.06 | +0.03 | buy |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 35,996 | 36,574 | +578 | 0.02 | 0.03 | +0.01 | buy |
| HAZLETT, BURT & WATSON, INC. | 147 | 100 | -47 | 0.00 | 0.00 | +0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 31,714 | 31,657 | -57 | 0.03 | 0.04 | +0.02 | sell |
| SATURNA CAPITAL CORP | 26,200 | 25,200 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| Pekin Hardy Strauss, Inc. | 56,000 | 53,000 | -3,000 | 0.04 | 0.06 | +0.02 | sell |
| Intellectus Partners, LLC | 120,279 | 116,679 | -3,600 | 0.17 | 0.27 | +0.10 | sell |
| AXQ CAPITAL, LP | 21,700 | 17,400 | -4,300 | 0.03 | 0.04 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 21,792 | 11,703 | -10,089 | 0.01 | 0.01 | +0.01 | sell |
| E Fund Management Co., Ltd. | 76,850 | 66,738 | -10,112 | 0.03 | 0.03 | +0.01 | sell |
| PROFUND ADVISORS LLC | 250,510 | 202,426 | -48,084 | 0.06 | 0.07 | +0.01 | sell |
| Zimmer Partners, LP | 588,000 | 495,000 | -93,000 | 0.07 | 0.15 | +0.08 | sell |
| GREAT LAKES ADVISORS, LLC | 276,534 | 136,183 | -140,351 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 430,200 | 275,000 | -155,200 | 0.02 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 5,036,479 | 4,827,670 | -208,809 | 0.04 | 0.06 | +0.02 | sell |
| Rafferty Asset Management, LLC | 1,496,170 | 1,247,515 | -248,655 | 0.04 | 0.04 | +0.00 | sell |
| ALGERT GLOBAL LLC | 393,776 | 120,088 | -273,688 | 0.08 | 0.04 | -0.04 | sell |
| 683 Capital Management, LLC | 2,050,000 | 1,750,000 | -300,000 | 0.73 | 1.17 | +0.44 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,597,120 | 3,276,602 | -320,518 | 0.00 | 0.00 | +0.00 | sell |
| Long Focus Capital Management, LLC | 2,470,521 | 2,135,521 | -335,000 | 0.40 | 0.58 | +0.18 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 4,476,836 | 3,926,159 | -550,677 | 0.06 | 0.09 | +0.03 | sell |
| Soleus Capital Management, L.P. | 1,239,777 | 555,000 | -684,777 | 0.52 | 0.50 | -0.02 | sell |
| SECTORAL ASSET MANAGEMENT INC | 985,000 | 198,800 | -786,200 | 0.87 | 0.70 | -0.18 | sell |
| Brevan Howard Capital Management LP | 1,562,686 | 692,775 | -869,911 | 2.11 | 0.57 | -1.54 | sell |
| Candriam S.C.A. | 2,747,853 | 1,727,822 | -1,020,031 | 0.09 | 0.10 | +0.01 | sell |
| Pictet Asset Management Holding SA | 6,913,684 | 5,263,309 | -1,650,375 | 0.04 | 0.05 | +0.01 | sell |