| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Palo Alto Investors LP | 0 | 2,106,792 | +2,106,792 | 0.00 | 1.54 | +1.54 | buy |
| DEUTSCHE BANK AG\ | 503,287 | 1,915,412 | +1,412,125 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,482,125 | 3,715,545 | +1,233,420 | 0.00 | 0.00 | +0.00 | buy |
| Invenomic Capital Management LP | 0 | 1,053,251 | +1,053,251 | 0.00 | 0.46 | +0.46 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 1,021,818 | +1,021,818 | 0.00 | 0.07 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.75 | +0.75 | buy |
| Woodline Partners LP | 646,295 | 1,604,706 | +958,411 | 0.03 | 0.14 | +0.11 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 200,424 | 983,080 | +782,656 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 151,091 | 837,158 | +686,067 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 22,143,470 | 22,812,820 | +669,350 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 637,742 | +637,742 | 0.00 | 0.19 | +0.19 | buy |
| UBS Group AG | 241,388 | 857,308 | +615,920 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 562,000 | +562,000 | 0.00 | 0.03 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 0 | 468,821 | +468,821 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,245,037 | 1,598,930 | +353,893 | 0.01 | 0.02 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 324,736 | +324,736 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 294,763 | +294,763 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,749,411 | 5,037,098 | +287,687 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 610,000 | 897,000 | +287,000 | 0.90 | 1.94 | +1.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 301,311 | 552,847 | +251,536 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 119,801 | 367,000 | +247,199 | 0.00 | 0.01 | +0.00 | buy |
| Parametrica Management Ltd | 95,400 | 320,276 | +224,876 | 0.73 | 4.27 | +3.54 | buy |
| NFJ INVESTMENT GROUP, LLC | 0 | 212,745 | +212,745 | 0.00 | 0.05 | +0.05 | buy |
| SIMPLEX TRADING, LLC | 175,417 | 374,067 | +198,650 | 0.03 | 0.09 | +0.07 | buy |
| NORTHERN TRUST CORP | 1,993,179 | 2,182,877 | +189,698 | 0.00 | 0.00 | +0.00 | buy |
| Arete Wealth Advisors, LLC | 33,000 | 216,250 | +183,250 | 0.03 | 0.13 | +0.11 | buy |
| D. E. Shaw & Co., Inc. | 37,762 | 215,134 | +177,372 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 950,000 | 1,116,818 | +166,818 | 0.47 | 0.91 | +0.44 | buy |
| BANQUE PICTET & CIE SA | 633,794 | 778,038 | +144,244 | 0.03 | 0.07 | +0.04 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 109,101 | +109,101 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 180,495 | 286,034 | +105,539 | 0.05 | 0.13 | +0.08 | buy |
| JPMORGAN CHASE & CO | 2,746,356 | 2,839,667 | +93,311 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 91,155 | +91,155 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 230,154 | 308,754 | +78,600 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 757,951 | 836,175 | +78,224 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 58,862 | 122,127 | +63,265 | 0.00 | 0.01 | +0.00 | buy |
| J.W. COLE ADVISORS, INC. | 0 | 62,292 | +62,292 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,692,533 | 1,747,023 | +54,490 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 101,573 | 155,145 | +53,572 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 200,000 | 250,000 | +50,000 | 0.97 | 1.63 | +0.67 | buy |
| ROYAL BANK OF CANADA | 42,020 | 81,981 | +39,961 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 39,873 | +39,873 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 35,468 | +35,468 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,148 | +33,148 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 45,568 | 76,740 | +31,172 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,186 | 35,333 | +29,147 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,722,711 | 1,750,907 | +28,196 | 0.50 | 0.82 | +0.33 | buy |
| Handelsbanken Fonder AB | 29,200 | 55,700 | +26,500 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 5,056 | 31,494 | +26,438 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 103,544 | 129,136 | +25,592 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,356 | 29,602 | +23,246 | 0.01 | 0.05 | +0.04 | buy |
| OSAIC HOLDINGS, INC. | 16,400 | 38,324 | +21,924 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 15,265 | 36,698 | +21,433 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 21,270 | +21,270 | 0.00 | 0.13 | +0.13 | buy |
| Bayesian Capital Management, LP | 14,400 | 35,400 | +21,000 | 0.01 | 0.03 | +0.02 | buy |
| GRIMES & COMPANY, INC. | 14,771 | 34,998 | +20,227 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 20,149 | +20,149 | 0.00 | 0.00 | +0.00 | buy |
| Close Asset Management Ltd | 0 | 19,550 | +19,550 | 0.00 | 0.01 | +0.01 | buy |
| Bank Pictet & Cie (Europe) AG | 43,724 | 62,963 | +19,239 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 11,962,938 | 11,979,415 | +16,477 | 1.83 | 2.18 | +0.35 | buy |
| RHUMBLINE ADVISERS | 352,167 | 368,456 | +16,289 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 15,407 | +15,407 | 0.00 | 0.00 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 0 | 15,290 | +15,290 | 0.00 | 0.03 | +0.03 | buy |
| StoneX Group Inc. | 0 | 14,999 | +14,999 | 0.00 | 0.01 | +0.01 | buy |
| INCEPTIONR LLC | 0 | 13,266 | +13,266 | 0.00 | 0.08 | +0.08 | buy |
| BAILARD, INC. | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 333,974 | 346,190 | +12,216 | 0.01 | 0.02 | +0.01 | buy |
| CALTON & ASSOCIATES, INC. | 0 | 12,090 | +12,090 | 0.00 | 0.04 | +0.04 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.01 | +0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 0 | 12,000 | +12,000 | 0.00 | 0.02 | +0.02 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 11,977 | +11,977 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 11,619 | +11,619 | 0.00 | 0.00 | -0.00 | buy |
| DUMONT & BLAKE INVESTMENT ADVISORS LLC | 0 | 11,500 | +11,500 | 0.00 | 0.03 | +0.03 | buy |
| Clear Harbor Asset Management, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| Baird Financial Group, Inc. | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 25,017 | 35,768 | +10,751 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 10,741 | +10,741 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 10,462 | +10,462 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4,587 | 14,757 | +10,170 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 1,992,335 | 2,001,510 | +9,175 | 0.29 | 0.45 | +0.16 | buy |
| Legal & General Group Plc | 219,630 | 228,251 | +8,621 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 45,994 | 54,319 | +8,325 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 64,863 | 72,733 | +7,870 | 0.06 | 0.11 | +0.05 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 37,488 | 44,765 | +7,277 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 19,857 | 26,603 | +6,746 | 0.00 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 16,079 | 22,712 | +6,633 | 0.02 | 0.05 | +0.03 | buy |
| SIGNATUREFD, LLC | 2,446 | 8,723 | +6,277 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,964 | 7,541 | +5,577 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 38,990 | 44,145 | +5,155 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 381 | 5,059 | +4,678 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 22,598 | 26,921 | +4,323 | 0.00 | 0.00 | +0.00 | buy |
| Carnegie Investment Counsel | 23,400 | 27,400 | +4,000 | 0.00 | 0.01 | +0.00 | buy |
| Belvedere Trading LLC | 589 | 4,323 | +3,734 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 63,061 | 66,654 | +3,593 | 0.01 | 0.01 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 17,871 | 20,559 | +2,688 | 0.00 | 0.01 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 7,230 | 9,630 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 3,681 | 6,001 | +2,320 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 3,287,397 | 3,289,470 | +2,073 | 3.99 | 6.26 | +2.26 | buy |
| Pale Fire Capital SE | 15,100 | 17,024 | +1,924 | 0.01 | 0.02 | +0.01 | buy |
| Diversified Trust Co | 12,031 | 13,512 | +1,481 | 0.00 | 0.00 | +0.00 | buy |