| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 27,313,967 | 27,534,340 | +220,373 | 0.00 | 0.00 | -0.00 | buy |
| MHR FUND MANAGEMENT LLC | 23,997,103 | 24,417,103 | +420,000 | 24.57 | 19.98 | -4.59 | buy |
| BlackRock, Inc. | 21,483,668 | 23,476,035 | +1,992,367 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 26,617,709 | 22,112,266 | -4,505,443 | 5.36 | 4.56 | -0.80 | sell |
| STATE STREET CORP | 13,201,978 | 12,249,282 | -952,696 | 0.01 | 0.00 | -0.00 | sell |
| Hood River Capital Management LLC | 8,144,637 | 8,991,573 | +846,936 | 1.23 | 0.98 | -0.25 | buy |
| Soleus Capital Management, L.P. | 8,528,500 | 6,560,000 | -1,968,500 | 6.66 | 3.67 | -2.98 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 5,648,995 | 5,871,420 | +222,425 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 5,861,279 | 5,834,456 | -26,823 | 0.03 | 0.03 | -0.01 | sell |
| Long Focus Capital Management, LLC | 4,532,000 | 5,132,000 | +600,000 | 3.76 | 2.91 | -0.86 | buy |
| MACQUARIE GROUP LTD | 3,190,036 | 4,750,934 | +1,560,898 | 0.03 | 0.04 | +0.01 | buy |
| Artisan Partners Limited Partnership | 4,803,825 | 4,542,168 | -261,657 | 0.07 | 0.05 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 4,390,032 | 4,110,056 | -279,976 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 2,148,574 | 3,959,839 | +1,811,265 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 4,033,184 | 3,646,787 | -386,397 | 0.02 | 0.01 | -0.01 | sell |
| Avoro Capital Advisors LLC | 4,240,000 | 3,500,000 | -740,000 | 0.58 | 0.37 | -0.21 | sell |
| Palo Alto Investors LP | 3,041,685 | 3,041,685 | 0 | 3.71 | 3.49 | -0.22 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 4,472,576 | 2,819,799 | -1,652,777 | 0.11 | 0.05 | -0.06 | sell |
| UBS Group AG | 622,129 | 2,704,469 | +2,082,340 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,406,714 | 2,673,905 | +267,191 | 3.39 | 2.81 | -0.58 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,413,917 | 2,662,695 | +1,248,778 | 0.02 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,102,912 | 2,628,101 | -474,811 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,069,592 | 2,430,221 | +360,629 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 2,414,996 | +2,414,996 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 2,248,576 | 2,414,807 | +166,231 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,913,144 | 1,989,340 | +76,196 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,946,842 | 1,907,727 | -39,115 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 0 | 1,746,877 | +1,746,877 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 1,282,968 | 1,696,301 | +413,333 | 0.48 | 0.43 | -0.05 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,679,157 | 1,594,532 | -84,625 | 0.85 | 0.65 | -0.21 | sell |
| 683 Capital Management, LLC | 1,400,000 | 1,416,014 | +16,014 | 1.34 | 1.03 | -0.31 | buy |
| APIS CAPITAL ADVISORS, LLC | 675,000 | 1,363,000 | +688,000 | 4.41 | 6.72 | +2.31 | buy |
| JPMORGAN CHASE & CO | 1,892,932 | 1,306,826 | -586,106 | 0.00 | 0.00 | -0.00 | sell |
| C WorldWide Group Holding A/S | 1,260,000 | 1,260,000 | 0 | 0.12 | 0.11 | -0.01 | hold |
| Rhenman & Partners Asset Management AB | 1,052,500 | 1,235,448 | +182,948 | 0.80 | 0.94 | +0.14 | buy |
| MARSHALL WACE, LLP | 0 | 1,130,455 | +1,130,455 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,220,257 | 1,121,417 | -98,840 | 0.02 | 0.01 | -0.00 | sell |
| Siren, L.L.C. | 1,106,040 | 1,106,040 | 0 | 0.52 | 0.36 | -0.16 | hold |
| CITADEL ADVISORS LLC | 1,023,836 | 1,093,604 | +69,768 | 0.01 | 0.01 | -0.00 | buy |
| Orion Investment Co | 906,285 | 1,060,755 | +154,470 | 3.31 | 3.13 | -0.18 | buy |
| STEMPOINT CAPITAL LP | 0 | 949,401 | +949,401 | 0.00 | 1.76 | +1.76 | buy |
| DEUTSCHE BANK AG\ | 755,481 | 867,576 | +112,095 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 841,969 | 865,834 | +23,865 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 902,268 | 831,059 | -71,209 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 631,130 | 765,399 | +134,269 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,450,838 | 741,418 | -1,709,420 | 0.00 | 0.00 | -0.00 | sell |
| QVT Financial LP | 678,564 | 678,564 | 0 | 0.55 | 0.45 | -0.10 | hold |
| BARCLAYS PLC | 604,584 | 617,803 | +13,219 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 575,844 | 580,245 | +4,401 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 74,592 | 577,265 | +502,673 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 562,435 | 563,577 | +1,142 | 0.04 | 0.03 | -0.02 | buy |
| Rafferty Asset Management, LLC | 652,966 | 554,141 | -98,825 | 0.02 | 0.01 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.34 | 0.24 | -0.09 | hold |
| CITIGROUP INC | 208,764 | 484,042 | +275,278 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 469,516 | 478,481 | +8,965 | 0.01 | 0.00 | -0.00 | buy |
| Neo Ivy Capital Management | 0 | 453,138 | +453,138 | 0.00 | 0.68 | +0.68 | buy |
| Swiss National Bank | 382,356 | 417,856 | +35,500 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 767,045 | 416,237 | -350,808 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 354,071 | 385,770 | +31,699 | 0.00 | 0.00 | -0.00 | buy |
| BANQUE PICTET & CIE SA | 321,759 | 376,591 | +54,832 | 0.03 | 0.03 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 351,449 | 335,981 | -15,468 | 0.15 | 0.11 | -0.04 | sell |
| Cinctive Capital Management LP | 0 | 329,204 | +329,204 | 0.00 | 0.13 | +0.13 | buy |
| FIRST TRUST ADVISORS LP | 0 | 324,246 | +324,246 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 369,278 | 311,078 | -58,200 | 0.00 | 0.00 | -0.00 | sell |
| CM Management, LLC | 250,000 | 300,000 | +50,000 | 1.87 | 1.98 | +0.11 | buy |
| JANE STREET GROUP, LLC | 116,970 | 295,228 | +178,258 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 311,907 | 279,627 | -32,280 | 0.00 | 0.00 | -0.00 | sell |
| Parametrica Management Ltd | 261,090 | 261,090 | 0 | 2.92 | 2.55 | -0.36 | hold |
| LPL Financial LLC | 234,455 | 250,707 | +16,252 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 243,296 | 243,296 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 219,105 | 232,654 | +13,549 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 173,655 | 226,834 | +53,179 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 216,961 | 221,928 | +4,967 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 292,095 | 214,997 | -77,098 | 0.01 | 0.01 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 223,107 | 209,999 | -13,108 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 189,467 | 203,241 | +13,774 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 209,164 | 200,207 | -8,957 | 0.00 | 0.00 | -0.00 | sell |
| Baird Financial Group, Inc. | 193,845 | 195,845 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 414,673 | 190,183 | -224,490 | 0.04 | 0.01 | -0.03 | sell |
| NFJ INVESTMENT GROUP, LLC | 189,655 | 187,342 | -2,313 | 0.05 | 0.04 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 164,316 | 178,303 | +13,987 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 173,044 | 169,737 | -3,307 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 146,416 | 165,842 | +19,426 | 0.01 | 0.01 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 113,952 | 155,684 | +41,732 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 307,384 | 152,342 | -155,042 | 0.01 | 0.00 | -0.01 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 113,777 | 149,913 | +36,136 | 0.03 | 0.03 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 97,958 | 147,348 | +49,390 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 144,280 | 141,480 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 135,379 | 136,530 | +1,151 | 0.01 | 0.01 | -0.00 | buy |
| PFM Health Sciences, LP | 132,152 | 132,152 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Aberdeen Group plc | 131,800 | 131,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 198,674 | 126,654 | -72,020 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 82,662 | 117,439 | +34,777 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 129,482 | 117,426 | -12,056 | 0.00 | 0.00 | -0.00 | sell |
| Intellectus Partners, LLC | 113,329 | 114,912 | +1,583 | 0.27 | 0.19 | -0.08 | buy |
| SIT INVESTMENT ASSOCIATES INC | 109,325 | 109,325 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Curi Capital, LLC | 108,637 | 108,637 | 0 | 0.02 | 0.02 | -0.00 | hold |
| PROFUND ADVISORS LLC | 128,804 | 107,883 | -20,921 | 0.05 | 0.03 | -0.02 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 65,525 | 106,884 | +41,359 | 0.06 | 0.08 | +0.02 | buy |
| GREAT LAKES ADVISORS, LLC | 112,080 | 104,322 | -7,758 | 0.01 | 0.01 | -0.00 | sell |