| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rosalind Advisors, Inc. | 3,905,743 | 3,905,743 | 0 | 3.33 | 2.53 | -0.79 | hold |
| Nantahala Capital Management, LLC | 3,376,484 | 3,376,484 | 0 | 0.50 | 0.36 | -0.14 | hold |
| Aberdeen Group plc | 2,481,117 | 3,173,364 | +692,247 | 0.01 | 0.01 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 2,133,405 | 3,133,405 | +1,000,000 | 0.12 | 0.11 | -0.01 | buy |
| Parkman Healthcare Partners LLC | 2,440,633 | 2,416,518 | -24,115 | 0.65 | 0.41 | -0.24 | sell |
| Velan Capital Investment Management LP | 2,143,698 | 2,143,698 | 0 | 4.85 | 2.22 | -2.63 | hold |
| MARSHALL WACE, LLP | 1,860,405 | 1,860,405 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 1,470,934 | 1,150,000 | -320,934 | 0.19 | 0.09 | -0.10 | sell |
| PURA VIDA INVESTMENTS, LLC | 450,517 | 450,517 | 0 | 6.62 | 3.00 | -3.62 | hold |
| INGALLS & SNYDER LLC | 225,002 | 384,300 | +159,298 | 0.02 | 0.03 | +0.01 | buy |
| Affiance Financial, LLC | 250,370 | 250,370 | 0 | 0.11 | 0.07 | -0.04 | hold |
| CITADEL ADVISORS LLC | 0 | 193,710 | +193,710 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 147,423 | 124,090 | -23,333 | 0.00 | 0.00 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 114,085 | +114,085 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 53,714 | 60,895 | +7,181 | 0.00 | 0.00 | -0.00 | buy |
| COURIER CAPITAL LLC | 55,000 | 55,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VESTIA PERSONAL WEALTH ADVISORS | 42,425 | 42,425 | 0 | 0.06 | 0.03 | -0.02 | hold |
| NORTHERN TRUST CORP | 33,572 | 33,572 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 32,550 | 32,550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legato Capital Management LLC | 0 | 26,850 | +26,850 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 86,092 | 23,334 | -62,758 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 19,569 | 19,714 | +145 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 18,244 | 18,244 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtu Financial LLC | 0 | 17,684 | +17,684 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 17,019 | +17,019 | 0.00 | 0.00 | +0.00 | buy |
| Avestar Capital, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 0 | 11,789 | +11,789 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 11,000 | 11,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 0 | 10,089 | +10,089 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| McKinley Carter Wealth Services, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AdvisorNet Financial, Inc | 8,783 | 8,783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 462 | 3,175 | +2,713 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 27 | 27 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BELLEVUE ASSET MANAGEMENT, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 61,579 | 0 | -61,579 | 0.06 | 0.00 | -0.06 | sell |
| HOLLENCREST CAPITAL MANAGEMENT | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Huntleigh Advisors, Inc. | 264,004 | 0 | -264,004 | 0.11 | 0.00 | -0.11 | sell |
| Mesirow Financial Investment Management, Inc. | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| Ghisallo Capital Management LLC | 921,587 | 0 | -921,587 | 0.07 | 0.00 | -0.07 | sell |
| SBI Securities Co., Ltd. | 230 | 0 | -230 | 0.00 | 0.00 | -0.00 | sell |
| Koesten, Hirschmann & Crabtree, INC. | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Uniting Wealth Partners, LLC | 21,066 | 0 | -21,066 | 0.01 | 0.00 | -0.01 | sell |