| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 7,967,836 | 13,133,131 | +5,165,295 | 4.37 | 6.76 | +2.39 | buy |
| Orbis Allan Gray Ltd | 12,925,578 | 11,368,161 | -1,557,417 | 1.46 | 1.07 | -0.39 | sell |
| ALLIANCEBERNSTEIN L.P. | 9,557,149 | 8,644,877 | -912,272 | 0.10 | 0.08 | -0.02 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,462,000 | 6,865,000 | +4,403,000 | 0.78 | 1.97 | +1.19 | buy |
| Deep Track Capital, LP | 3,663,250 | 5,650,000 | +1,986,750 | 2.03 | 2.29 | +0.26 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 4,975,324 | 4,975,324 | 0 | 0.07 | 0.06 | -0.01 | hold |
| BlackRock, Inc. | 4,536,565 | 4,671,252 | +134,687 | 0.00 | 0.00 | -0.00 | buy |
| Sofinnova Investments, Inc. | 752,261 | 4,045,215 | +3,292,954 | 1.01 | 5.94 | +4.92 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 4,414,550 | 3,517,850 | -896,700 | 0.19 | 0.13 | -0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 2,339,432 | 3,506,843 | +1,167,411 | 0.05 | 0.07 | +0.02 | buy |
| HARDING LOEVNER LP | 3,231,601 | 3,086,318 | -145,283 | 0.89 | 0.82 | -0.08 | sell |
| FIRST TRUST ADVISORS LP | 2,461,342 | 2,756,522 | +295,180 | 0.05 | 0.04 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 2,475,991 | +2,475,991 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 677,346 | 1,689,284 | +1,011,938 | 0.03 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 2,184,701 | 1,630,161 | -554,540 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,251,590 | 1,449,376 | +197,786 | 0.05 | 0.06 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 931,259 | 1,279,231 | +347,972 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,193,145 | 1,202,923 | +9,778 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,077,471 | 1,065,927 | -11,544 | 0.03 | 0.03 | -0.00 | sell |
| UBS Group AG | 298,132 | 961,053 | +662,921 | 0.00 | 0.00 | +0.00 | buy |
| Perpetual Ltd | 758,503 | 919,048 | +160,545 | 0.31 | 0.36 | +0.05 | buy |
| NORTHERN TRUST CORP | 950,534 | 916,600 | -33,934 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 792,293 | 910,604 | +118,311 | 0.02 | 0.02 | +0.00 | buy |
| Russell Investments Group, Ltd. | 776,976 | 860,493 | +83,517 | 0.02 | 0.02 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 862,301 | 829,687 | -32,614 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 15,000 | 829,659 | +814,659 | 0.00 | 0.02 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 645,481 | 804,374 | +158,893 | 0.05 | 0.06 | +0.01 | buy |
| FMR LLC | 1,011,726 | 764,694 | -247,032 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 222,607 | 744,815 | +522,208 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 538,944 | 599,953 | +61,009 | 0.01 | 0.01 | -0.00 | buy |
| CIBC WORLD MARKET INC. | 488,266 | 514,764 | +26,498 | 0.02 | 0.02 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 457,508 | 447,426 | -10,082 | 0.14 | 0.13 | -0.01 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 196,709 | 430,600 | +233,891 | 3.77 | 7.47 | +3.70 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 211,705 | 420,487 | +208,782 | 0.21 | 0.26 | +0.06 | buy |
| Dixon Mitchell Investment Counsel Inc. | 0 | 416,000 | +416,000 | 0.00 | 0.37 | +0.37 | buy |
| Quantinno Capital Management LP | 282,498 | 333,388 | +50,890 | 0.01 | 0.01 | -0.00 | buy |
| Hudson Bay Capital Management LP | 310,000 | 330,000 | +20,000 | 0.05 | 0.04 | -0.01 | buy |
| SummitTX Capital, L.P. | 84,354 | 318,408 | +234,054 | 0.07 | 0.23 | +0.16 | buy |
| WELLS FARGO & COMPANY/MN | 319,592 | 303,639 | -15,953 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 241,520 | 259,249 | +17,729 | 0.00 | 0.00 | -0.00 | buy |
| EAGLE GLOBAL ADVISORS LLC | 244,565 | 244,730 | +165 | 0.24 | 0.22 | -0.01 | buy |
| ASSETMARK, INC | 224,144 | 238,803 | +14,659 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 227,587 | 227,990 | +403 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 199,774 | +199,774 | 0.00 | 0.19 | +0.19 | buy |
| FOLKETRYGDFONDET | 160,773 | 165,082 | +4,309 | 0.08 | 0.10 | +0.02 | buy |
| JANE STREET GROUP, LLC | 98,432 | 164,743 | +66,311 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 184,124 | 162,384 | -21,740 | 0.02 | 0.01 | -0.00 | sell |
| AIMZ Investment Advisors, LLC | 160,910 | 160,910 | 0 | 1.33 | 1.22 | -0.12 | hold |
| LPL Financial LLC | 188,637 | 144,321 | -44,316 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 13,467 | 141,353 | +127,886 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 139,125 | +139,125 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,571 | 139,125 | +11,554 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 135,647 | +135,647 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 133,387 | +133,387 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 150,135 | 127,889 | -22,246 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 118,596 | 119,169 | +573 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 83,279 | 106,104 | +22,825 | 0.00 | 0.00 | -0.00 | buy |
| Legacy Wealth Asset Management, LLC | 38,680 | 102,164 | +63,484 | 0.25 | 0.62 | +0.36 | buy |
| SEI INVESTMENTS CO | 93,012 | 91,324 | -1,688 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Quantitative Investments LLC | 36,355 | 90,718 | +54,363 | 0.18 | 0.41 | +0.23 | buy |
| US BANCORP \DE\ | 95,548 | 88,420 | -7,128 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 33,399 | 78,569 | +45,170 | 0.01 | 0.02 | +0.01 | buy |
| Cetera Investment Advisers | 81,420 | 76,454 | -4,966 | 0.00 | 0.00 | -0.00 | sell |
| QRG CAPITAL MANAGEMENT, INC. | 65,822 | 72,643 | +6,821 | 0.02 | 0.02 | -0.00 | buy |
| IMC-Chicago, LLC | 0 | 71,596 | +71,596 | 0.00 | 0.02 | +0.02 | buy |
| Madison Asset Management, LLC | 70,970 | 70,781 | -189 | 0.02 | 0.02 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 66,902 | 69,579 | +2,677 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 65,130 | 65,711 | +581 | 0.00 | 0.00 | -0.00 | buy |
| Terra Nova Asset Management LLC | 42,644 | 64,239 | +21,595 | 0.85 | 1.08 | +0.23 | buy |
| NATIXIS ADVISORS, LLC | 70,980 | 62,632 | -8,348 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 61,924 | 60,207 | -1,717 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 58,921 | 60,106 | +1,185 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 79,105 | 58,237 | -20,868 | 0.00 | 0.00 | -0.00 | sell |
| LEVEL FOUR ADVISORY SERVICES, LLC | 57,023 | 58,000 | +977 | 0.05 | 0.05 | -0.01 | buy |
| MML INVESTORS SERVICES, LLC | 38,230 | 55,948 | +17,718 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 59,306 | 55,781 | -3,525 | 0.02 | 0.01 | -0.00 | sell |
| Callan Family Office, LLC | 55,047 | 55,033 | -14 | 0.03 | 0.03 | -0.00 | sell |
| Mariner, LLC | 56,309 | 54,677 | -1,632 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 52,688 | 52,043 | -645 | 0.00 | 0.00 | -0.00 | sell |
| INGALLS & SNYDER LLC | 72,891 | 50,841 | -22,050 | 0.07 | 0.04 | -0.03 | sell |
| Neuberger Berman Group LLC | 53,962 | 50,557 | -3,405 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 50,000 | 50,000 | 0 | 0.27 | 0.22 | -0.05 | hold |
| Vanguard Personalized Indexing Management, LLC | 57,292 | 49,511 | -7,781 | 0.02 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 56,438 | 49,015 | -7,423 | 0.00 | 0.00 | -0.00 | sell |
| Entropy Technologies, LP | 0 | 48,654 | +48,654 | 0.00 | 0.05 | +0.05 | buy |
| FIFTH THIRD BANCORP | 47,371 | 47,181 | -190 | 0.00 | 0.00 | -0.00 | sell |
| BAROMETER CAPITAL MANAGEMENT INC. | 42,400 | 45,400 | +3,000 | 0.39 | 0.35 | -0.04 | buy |
| Vident Advisory, LLC | 48,379 | 44,400 | -3,979 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 43,172 | +43,172 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 0 | 42,948 | +42,948 | 0.00 | 0.00 | +0.00 | buy |
| DAVENPORT & Co LLC | 44,901 | 42,544 | -2,357 | 0.01 | 0.01 | -0.00 | sell |
| LMR Partners LLP | 0 | 42,196 | +42,196 | 0.00 | 0.01 | +0.01 | buy |
| WINTON GROUP Ltd | 15,800 | 40,900 | +25,100 | 0.01 | 0.04 | +0.02 | buy |
| RHUMBLINE ADVISERS | 39,562 | 39,985 | +423 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 39,702 | 39,904 | +202 | 0.00 | 0.00 | -0.00 | buy |
| TRUIST FINANCIAL CORP | 42,057 | 38,356 | -3,701 | 0.00 | 0.00 | -0.00 | sell |
| GRANDFIELD & DODD, LLC | 37,163 | 37,633 | +470 | 0.06 | 0.05 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 32,644 | 32,612 | -32 | 0.00 | 0.00 | -0.00 | sell |
| GTS SECURITIES LLC | 0 | 32,116 | +32,116 | 0.00 | 0.02 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 55,399 | 31,361 | -24,038 | 0.01 | 0.01 | -0.01 | sell |