| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 7,967,836 | 13,133,131 | +5,165,295 | 4.37 | 6.76 | +2.39 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,462,000 | 6,865,000 | +4,403,000 | 0.78 | 1.97 | +1.19 | buy |
| Sofinnova Investments, Inc. | 752,261 | 4,045,215 | +3,292,954 | 1.01 | 5.94 | +4.92 | buy |
| CITADEL ADVISORS LLC | 0 | 2,475,991 | +2,475,991 | 0.00 | 0.04 | +0.04 | buy |
| Deep Track Capital, LP | 3,663,250 | 5,650,000 | +1,986,750 | 2.03 | 2.29 | +0.26 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,339,432 | 3,506,843 | +1,167,411 | 0.05 | 0.07 | +0.02 | buy |
| Qube Research & Technologies Ltd | 677,346 | 1,689,284 | +1,011,938 | 0.03 | 0.05 | +0.03 | buy |
| MARSHALL WACE, LLP | 15,000 | 829,659 | +814,659 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 298,132 | 961,053 | +662,921 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 222,607 | 744,815 | +522,208 | 0.00 | 0.00 | +0.00 | buy |
| Dixon Mitchell Investment Counsel Inc. | 0 | 416,000 | +416,000 | 0.00 | 0.37 | +0.37 | buy |
| GOLDMAN SACHS GROUP INC | 931,259 | 1,279,231 | +347,972 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 2,461,342 | 2,756,522 | +295,180 | 0.05 | 0.04 | -0.00 | buy |
| SummitTX Capital, L.P. | 84,354 | 318,408 | +234,054 | 0.07 | 0.23 | +0.16 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 196,709 | 430,600 | +233,891 | 3.77 | 7.47 | +3.70 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 211,705 | 420,487 | +208,782 | 0.21 | 0.26 | +0.06 | buy |
| Caption Management, LLC | 0 | 199,774 | +199,774 | 0.00 | 0.19 | +0.19 | buy |
| FEDERATED HERMES, INC. | 1,251,590 | 1,449,376 | +197,786 | 0.05 | 0.06 | +0.00 | buy |
| Perpetual Ltd | 758,503 | 919,048 | +160,545 | 0.31 | 0.36 | +0.05 | buy |
| Alyeska Investment Group, L.P. | 645,481 | 804,374 | +158,893 | 0.05 | 0.06 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 139,125 | +139,125 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 135,647 | +135,647 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 4,536,565 | 4,671,252 | +134,687 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 133,387 | +133,387 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 13,467 | 141,353 | +127,886 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 792,293 | 910,604 | +118,311 | 0.02 | 0.02 | +0.00 | buy |
| Russell Investments Group, Ltd. | 776,976 | 860,493 | +83,517 | 0.02 | 0.02 | -0.00 | buy |
| IMC-Chicago, LLC | 0 | 71,596 | +71,596 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 98,432 | 164,743 | +66,311 | 0.00 | 0.00 | +0.00 | buy |
| Legacy Wealth Asset Management, LLC | 38,680 | 102,164 | +63,484 | 0.25 | 0.62 | +0.36 | buy |
| AMERICAN CENTURY COMPANIES INC | 538,944 | 599,953 | +61,009 | 0.01 | 0.01 | -0.00 | buy |
| Integrated Quantitative Investments LLC | 36,355 | 90,718 | +54,363 | 0.18 | 0.41 | +0.23 | buy |
| Quantinno Capital Management LP | 282,498 | 333,388 | +50,890 | 0.01 | 0.01 | -0.00 | buy |
| Entropy Technologies, LP | 0 | 48,654 | +48,654 | 0.00 | 0.05 | +0.05 | buy |
| Quadrature Capital Ltd | 33,399 | 78,569 | +45,170 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 43,172 | +43,172 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 0 | 42,948 | +42,948 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 42,196 | +42,196 | 0.00 | 0.01 | +0.01 | buy |
| GTS SECURITIES LLC | 0 | 32,116 | +32,116 | 0.00 | 0.02 | +0.02 | buy |
| CIBC WORLD MARKET INC. | 488,266 | 514,764 | +26,498 | 0.02 | 0.02 | +0.00 | buy |
| WINTON GROUP Ltd | 15,800 | 40,900 | +25,100 | 0.01 | 0.04 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 83,279 | 106,104 | +22,825 | 0.00 | 0.00 | -0.00 | buy |
| Terra Nova Asset Management LLC | 42,644 | 64,239 | +21,595 | 0.85 | 1.08 | +0.23 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 21,565 | +21,565 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 20,343 | +20,343 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 310,000 | 330,000 | +20,000 | 0.05 | 0.04 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 241,520 | 259,249 | +17,729 | 0.00 | 0.00 | -0.00 | buy |
| MML INVESTORS SERVICES, LLC | 38,230 | 55,948 | +17,718 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 17,530 | +17,530 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 14,943 | +14,943 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 224,144 | 238,803 | +14,659 | 0.01 | 0.01 | -0.00 | buy |
| Virtu Financial LLC | 0 | 14,517 | +14,517 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 13,003 | 27,141 | +14,138 | 0.04 | 0.08 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 13,090 | +13,090 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,571 | 139,125 | +11,554 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 10,849 | +10,849 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 10,369 | +10,369 | 0.00 | 0.18 | +0.18 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 10,203 | +10,203 | 0.00 | 0.04 | +0.04 | buy |
| Everstar Asset Management, LLC | 0 | 10,113 | +10,113 | 0.00 | 0.13 | +0.13 | buy |
| FRANKLIN RESOURCES INC | 1,193,145 | 1,202,923 | +9,778 | 0.01 | 0.01 | -0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 16,083 | 24,346 | +8,263 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 7,624 | +7,624 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 8,898 | 16,322 | +7,424 | 0.00 | 0.00 | +0.00 | buy |
| JUNCTURE WEALTH STRATEGIES, LLC | 0 | 7,341 | +7,341 | 0.00 | 0.05 | +0.05 | buy |
| Knollwood Investment Advisory, LLC | 0 | 7,300 | +7,300 | 0.00 | 0.02 | +0.02 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 65,822 | 72,643 | +6,821 | 0.02 | 0.02 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 695 | 7,260 | +6,565 | 0.00 | 0.00 | +0.00 | buy |
| FOLKETRYGDFONDET | 160,773 | 165,082 | +4,309 | 0.08 | 0.10 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 3,394 | +3,394 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Advisors Network LLC | 7,635 | 10,911 | +3,276 | 0.01 | 0.01 | +0.00 | buy |
| SYON CAPITAL LLC | 7,900 | 11,023 | +3,123 | 0.01 | 0.01 | +0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 42,400 | 45,400 | +3,000 | 0.39 | 0.35 | -0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 66,902 | 69,579 | +2,677 | 0.00 | 0.00 | -0.00 | buy |
| Kestra Advisory Services, LLC | 9,988 | 12,016 | +2,028 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 1,062 | 2,549 | +1,487 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 8,887 | 10,217 | +1,330 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 4,871 | 6,091 | +1,220 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 58,921 | 60,106 | +1,185 | 0.00 | 0.00 | -0.00 | buy |
| Aaron Wealth Advisors LLC | 9,285 | 10,431 | +1,146 | 0.01 | 0.01 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 1,116 | +1,116 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 13,861 | 14,928 | +1,067 | 0.00 | 0.00 | -0.00 | buy |
| LEVEL FOUR ADVISORY SERVICES, LLC | 57,023 | 58,000 | +977 | 0.05 | 0.05 | -0.01 | buy |
| Pinnacle Bancorp, Inc. | 0 | 817 | +817 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 16,073 | 16,885 | +812 | 0.00 | 0.00 | -0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 20,779 | 21,529 | +750 | 0.01 | 0.01 | -0.00 | buy |
| SIGNATUREFD, LLC | 15,780 | 16,442 | +662 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,424 | 12,077 | +653 | 0.02 | 0.02 | -0.00 | buy |
| Quantbot Technologies LP | 3,836 | 4,449 | +613 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 65,130 | 65,711 | +581 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 118,596 | 119,169 | +573 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 3,417 | 3,978 | +561 | 0.00 | 0.00 | -0.00 | buy |
| Strategic Investment Advisors / MI | 5,113 | 5,653 | +540 | 0.01 | 0.01 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 30,530 | 31,068 | +538 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 21,957 | 22,457 | +500 | 0.02 | 0.02 | -0.00 | buy |
| GRANDFIELD & DODD, LLC | 37,163 | 37,633 | +470 | 0.06 | 0.05 | -0.00 | buy |
| REGIONS FINANCIAL CORP | 14,646 | 15,096 | +450 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 4,691 | 5,126 | +435 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 39,562 | 39,985 | +423 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 227,587 | 227,990 | +403 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 1,885 | 2,264 | +379 | 0.00 | 0.00 | -0.00 | buy |