| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 13,169,057 | 13,169,057 | 0 | 1.76 | 3.55 | +1.79 | hold |
| VANGUARD GROUP INC | 9,293,363 | 9,911,007 | +617,644 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,861,919 | 8,036,669 | +6,174,750 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 5,572,607 | +5,572,607 | 0.00 | 1.18 | +1.18 | buy |
| Bellevue Group AG | 4,851,579 | 4,839,779 | -11,800 | 0.28 | 0.54 | +0.26 | sell |
| JOHNSON & JOHNSON | 3,379,064 | 3,379,064 | 0 | 0.29 | 0.56 | +0.27 | hold |
| CITADEL ADVISORS LLC | 2,666,208 | 3,131,526 | +465,318 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 1,321,356 | 3,065,789 | +1,744,433 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 3,581,979 | 2,730,966 | -851,013 | 0.02 | 0.03 | +0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 2,562,852 | +2,562,852 | 0.00 | 0.79 | +0.79 | buy |
| Assenagon Asset Management S.A. | 163,097 | 2,548,304 | +2,385,207 | 0.00 | 0.05 | +0.05 | buy |
| Holocene Advisors, LP | 0 | 2,527,747 | +2,527,747 | 0.00 | 0.07 | +0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 2,190,408 | +2,190,408 | 0.00 | 0.28 | +0.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,700,000 | 2,140,000 | +440,000 | 0.01 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 590,993 | 2,012,258 | +1,421,265 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,616,820 | 1,999,822 | -616,998 | 0.05 | 0.07 | +0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 607,004 | 1,919,776 | +1,312,772 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,863,485 | 1,905,983 | +42,498 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 385,364 | 1,892,002 | +1,506,638 | 0.02 | 0.13 | +0.11 | buy |
| BAKER BROS. ADVISORS LP | 0 | 1,818,181 | +1,818,181 | 0.00 | 0.17 | +0.17 | buy |
| JPMORGAN CHASE & CO | 2,072,506 | 1,759,321 | -313,185 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 2,281,171 | 1,714,124 | -567,047 | 0.03 | 0.04 | +0.01 | sell |
| Point72 Asset Management, L.P. | 3,489,163 | 1,584,300 | -1,904,863 | 0.04 | 0.03 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 1,876,900 | 1,437,700 | -439,200 | 0.02 | 0.02 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 528,080 | 1,355,352 | +827,272 | 0.04 | 0.18 | +0.14 | buy |
| DIMENSIONAL FUND ADVISORS LP | 320,774 | 1,063,179 | +742,405 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,849,872 | 1,007,378 | -842,494 | 0.02 | 0.02 | -0.00 | sell |
| Invesco Ltd. | 129,454 | 965,431 | +835,977 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 983,019 | 956,331 | -26,688 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 847,823 | 920,476 | +72,653 | 2.26 | 4.47 | +2.20 | buy |
| Schonfeld Strategic Advisors LLC | 497,457 | 886,925 | +389,468 | 0.02 | 0.05 | +0.04 | buy |
| Soleus Capital Management, L.P. | 0 | 870,000 | +870,000 | 0.00 | 0.56 | +0.56 | buy |
| Vestal Point Capital, LP | 1,290,000 | 800,000 | -490,000 | 0.51 | 0.49 | -0.03 | sell |
| Rafferty Asset Management, LLC | 0 | 729,657 | +729,657 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 708,589 | 716,052 | +7,463 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 0.24 | 0.53 | +0.29 | hold |
| CITIGROUP INC | 843,962 | 623,058 | -220,904 | 0.00 | 0.00 | +0.00 | sell |
| Octagon Capital Advisors LP | 0 | 520,800 | +520,800 | 0.00 | 0.46 | +0.46 | buy |
| GCM Grosvenor Holdings, LLC | 495,916 | 495,916 | 0 | 0.33 | 0.56 | +0.23 | hold |
| Hudson Bay Capital Management LP | 0 | 460,000 | +460,000 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 176,305 | 444,050 | +267,745 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 560,011 | 383,201 | -176,810 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 378,608 | +378,608 | 0.00 | 0.01 | +0.01 | buy |
| Artal Group S.A. | 0 | 360,311 | +360,311 | 0.00 | 0.07 | +0.07 | buy |
| MARSHALL WACE, LLP | 0 | 345,437 | +345,437 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 359,375 | 324,243 | -35,132 | 0.00 | 0.00 | +0.00 | sell |
| Monaco Asset Management SAM | 2,183,228 | 316,805 | -1,866,423 | 3.14 | 1.03 | -2.11 | sell |
| Bank of New York Mellon Corp | 321,952 | 301,993 | -19,959 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 251,649 | 284,390 | +32,741 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 54,357 | 274,289 | +219,932 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 16,511 | 266,009 | +249,498 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,550,659 | 265,000 | -1,285,659 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 0 | 257,716 | +257,716 | 0.00 | 0.04 | +0.04 | buy |
| FMR LLC | 291,172 | 255,646 | -35,526 | 0.00 | 0.00 | +0.00 | sell |
| Integral Health Asset Management, LLC | 900,000 | 200,000 | -700,000 | 0.49 | 0.14 | -0.34 | sell |
| JANE STREET GROUP, LLC | 711,287 | 194,659 | -516,628 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 12,504 | 183,950 | +171,446 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 161,450 | +161,450 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 151,121 | +151,121 | 0.00 | 0.05 | +0.05 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 154,178 | 147,799 | -6,379 | 0.00 | 0.00 | +0.00 | sell |
| Pennant Investors, LP | 146,100 | 146,100 | 0 | 0.17 | 0.30 | +0.13 | hold |
| RHUMBLINE ADVISERS | 140,335 | 144,176 | +3,841 | 0.00 | 0.00 | +0.00 | buy |
| Bruce & Co., Inc. | 143,000 | 143,000 | 0 | 0.19 | 0.35 | +0.16 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 132,700 | +132,700 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 52,982 | 131,579 | +78,597 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 112,351 | +112,351 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 233,748 | 110,248 | -123,500 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 160,760 | 100,380 | -60,380 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,509 | 93,336 | -59,173 | 0.00 | 0.00 | +0.00 | sell |
| Institute for Wealth Management, LLC. | 0 | 66,928 | +66,928 | 0.00 | 0.06 | +0.06 | buy |
| HSBC HOLDINGS PLC | 78,747 | 65,931 | -12,816 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,898 | 59,840 | +24,942 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 58,835 | +58,835 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 43,003 | 52,279 | +9,276 | 0.01 | 0.03 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 48,082 | +48,082 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 23,380 | 46,962 | +23,582 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 44,185 | +44,185 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 41,337 | 43,812 | +2,475 | 0.03 | 0.05 | +0.02 | buy |
| STIFEL FINANCIAL CORP | 43,950 | 43,790 | -160 | 0.00 | 0.00 | +0.00 | sell |
| ROYCE & ASSOCIATES LP | 107,318 | 43,399 | -63,919 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 42,126 | 41,767 | -359 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 38,340 | 41,013 | +2,673 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 37,825 | 39,982 | +2,157 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 19,636 | 39,800 | +20,164 | 0.01 | 0.03 | +0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 63,725 | 39,410 | -24,315 | 0.01 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 44,004 | 38,329 | -5,675 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 29,649 | 37,503 | +7,854 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 90,553 | 37,456 | -53,097 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 0 | 34,480 | +34,480 | 0.00 | 0.02 | +0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 33,910 | +33,910 | 0.00 | 0.00 | +0.00 | buy |
| Parcion Private Wealth LLC | 28,000 | 28,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,025 | 27,995 | -30 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 28,016 | 27,876 | -140 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 93,313 | 27,788 | -65,525 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 26,787 | 23,876 | -2,911 | 0.00 | 0.00 | +0.00 | sell |
| Focus Partners Wealth | 0 | 23,653 | +23,653 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 23,343 | +23,343 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 235,058 | 22,098 | -212,960 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 0 | 20,400 | +20,400 | 0.00 | 0.04 | +0.04 | buy |