| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,190,408 | 3,555,871 | +1,365,463 | 0.28 | 0.19 | -0.09 | buy |
| CITADEL ADVISORS LLC | 3,131,526 | 4,488,026 | +1,356,500 | 0.02 | 0.01 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 2,730,966 | 4,077,922 | +1,346,956 | 0.03 | 0.02 | -0.01 | buy |
| Vestal Point Capital, LP | 800,000 | 2,000,000 | +1,200,000 | 0.49 | 0.49 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,818,181 | 2,997,772 | +1,179,591 | 0.17 | 0.13 | -0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,063,179 | 2,130,280 | +1,067,101 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 265,000 | 1,019,987 | +754,987 | 0.00 | 0.01 | +0.00 | buy |
| Artal Group S.A. | 360,311 | 1,032,500 | +672,189 | 0.07 | 0.09 | +0.02 | buy |
| VANGUARD GROUP INC | 9,911,007 | 10,569,814 | +658,807 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 200,000 | 850,000 | +650,000 | 0.14 | 0.28 | +0.13 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 548,544 | +548,544 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 446,668 | +446,668 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 345,575 | +345,575 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,905,983 | 2,247,383 | +341,400 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,012,258 | 2,348,554 | +336,296 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 324,585 | +324,585 | 0.00 | 0.09 | +0.09 | buy |
| E Fund Management Co., Ltd. | 34,480 | 355,225 | +320,745 | 0.02 | 0.06 | +0.05 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,714,124 | 2,008,862 | +294,738 | 0.04 | 0.02 | -0.02 | buy |
| Jump Financial, LLC | 0 | 215,600 | +215,600 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 52,279 | 264,467 | +212,188 | 0.03 | 0.06 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 188,460 | +188,460 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 179,100 | +179,100 | 0.00 | 0.00 | +0.00 | buy |
| Bruce & Co., Inc. | 143,000 | 300,000 | +157,000 | 0.35 | 0.32 | -0.02 | buy |
| Squarepoint Ops LLC | 0 | 128,759 | +128,759 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 151,121 | 262,414 | +111,293 | 0.05 | 0.02 | -0.03 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 100,566 | +100,566 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,437,700 | 1,523,500 | +85,800 | 0.02 | 0.01 | -0.01 | buy |
| MORGAN STANLEY | 3,065,789 | 3,147,989 | +82,200 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,520 | 89,653 | +81,133 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 77,816 | +77,816 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 12,401 | 89,330 | +76,929 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 301,993 | 374,132 | +72,139 | 0.00 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 0 | 71,955 | +71,955 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,919,776 | 1,985,732 | +65,956 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 59,026 | +59,026 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 58,365 | +58,365 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 15,680 | 65,611 | +49,931 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,380 | 146,580 | +46,200 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 36,675 | +36,675 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 131,579 | 166,255 | +34,676 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 44,185 | 75,161 | +30,976 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 11,240 | 42,166 | +30,926 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 28,652 | +28,652 | 0.00 | 0.02 | +0.02 | buy |
| Headlands Technologies LLC | 532 | 28,508 | +27,976 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 19,823 | 47,468 | +27,645 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 2,548,304 | 2,574,703 | +26,399 | 0.05 | 0.02 | -0.03 | buy |
| Arizona State Retirement System | 0 | 25,486 | +25,486 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 24,223 | +24,223 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 1,007,378 | 1,031,505 | +24,127 | 0.02 | 0.01 | -0.01 | buy |
| Qube Research & Technologies Ltd | 11,310 | 35,134 | +23,824 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 194,659 | 217,739 | +23,080 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 65,931 | 88,514 | +22,583 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 38,329 | 59,989 | +21,660 | 0.00 | 0.00 | -0.00 | buy |
| DRW Securities, LLC | 0 | 21,550 | +21,550 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 716,052 | 736,674 | +20,622 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 19,999 | +19,999 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 19,065 | +19,065 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 18,600 | +18,600 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 17,053 | +17,053 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 17,388 | 33,898 | +16,510 | 0.02 | 0.01 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 41,013 | 57,252 | +16,239 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 144,176 | 160,001 | +15,825 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,201 | 22,117 | +13,916 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 11,565 | +11,565 | 0.00 | 0.00 | +0.00 | buy |
| Leo Wealth, LLC | 0 | 10,439 | +10,439 | 0.00 | 0.00 | +0.00 | buy |
| Ausdal Financial Partners, Inc. | 0 | 10,007 | +10,007 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 161,450 | 167,055 | +5,605 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 27,788 | 33,254 | +5,466 | 0.00 | 0.00 | -0.00 | buy |
| Amundi | 0 | 4,990 | +4,990 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,575 | +1,575 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 13,582 | 14,777 | +1,195 | 0.00 | 0.00 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 33,910 | 34,797 | +887 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 858 | +858 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 11,016 | 11,419 | +403 | 0.00 | 0.00 | -0.00 | buy |
| Bleakley Financial Group, LLC | 11,016 | 11,419 | +403 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 17,137 | 17,502 | +365 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 23,653 | 23,906 | +253 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 27,876 | 28,016 | +140 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 11,100 | 11,204 | +104 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Caitlin John, LLC | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 550 | 630 | +80 | 0.00 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,995 | 28,015 | +20 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 400 | 410 | +10 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| MATHER GROUP, LLC. | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ALBION FINANCIAL GROUP /UT | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 1,355,352 | 1,355,352 | 0 | 0.18 | 0.09 | -0.09 | hold |
| Ameritas Investment Partners, Inc. | 8,358 | 8,358 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EVERMAY WEALTH MANAGEMENT LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 0.53 | 0.23 | -0.30 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 132,700 | 132,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN ADVISORY INC | 19,338 | 19,338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redmile Group, LLC | 13,169,057 | 13,169,057 | 0 | 3.55 | 2.61 | -0.94 | hold |
| Parametrica Management Ltd | 18,472 | 18,472 | 0 | 0.20 | 0.08 | -0.12 | hold |
| Allworth Financial LP | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |