| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 13,169,057 | 13,169,057 | 0 | 2.61 | 2.72 | +0.10 | hold |
| VANGUARD GROUP INC | 10,569,814 | 10,404,123 | -165,691 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 5,572,607 | 5,572,607 | 0 | 0.55 | 0.62 | +0.08 | hold |
| STATE STREET CORP | 5,338,689 | 5,252,974 | -85,715 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 4,839,779 | 4,839,779 | 0 | 0.26 | 0.27 | +0.02 | hold |
| CITADEL ADVISORS LLC | 4,488,026 | 4,282,077 | -205,949 | 0.01 | 0.02 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,555,871 | 3,555,871 | 0 | 0.19 | 0.19 | -0.01 | hold |
| JOHNSON & JOHNSON | 3,379,064 | 3,379,064 | 0 | 2.77 | 2.77 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 4,077,922 | 3,377,650 | -700,272 | 0.02 | 0.02 | -0.00 | sell |
| Woodline Partners LP | 1,002,002 | 3,065,747 | +2,063,745 | 0.03 | 0.09 | +0.06 | buy |
| MORGAN STANLEY | 3,147,989 | 3,063,421 | -84,568 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 2,997,772 | 2,997,772 | 0 | 0.13 | 0.11 | -0.02 | hold |
| GOLDMAN SACHS GROUP INC | 2,348,554 | 2,823,403 | +474,849 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,130,280 | 2,619,017 | +488,737 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 2,574,703 | 2,434,198 | -140,505 | 0.02 | 0.02 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,247,383 | 2,258,246 | +10,863 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,429,545 | 1,837,304 | +407,759 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 2,000,000 | 1,685,000 | -315,000 | 0.49 | 0.47 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 1,355,352 | 1,680,580 | +325,228 | 0.09 | 0.11 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,008,862 | 1,602,120 | -406,742 | 0.02 | 0.02 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,694,217 | 1,587,900 | -106,317 | 0.02 | 0.02 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 497,360 | 1,466,934 | +969,574 | 2.06 | 4.59 | +2.53 | buy |
| Integral Health Asset Management, LLC | 850,000 | 975,000 | +125,000 | 0.28 | 0.40 | +0.12 | buy |
| TWO SIGMA ADVISERS, LP | 1,523,500 | 927,240 | -596,260 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 870,000 | 870,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 1,985,732 | 854,195 | -1,131,537 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 736,674 | 815,160 | +78,486 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 879,375 | 763,808 | -115,567 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 0.23 | 0.18 | -0.06 | hold |
| FEDERATED HERMES, INC. | 1,031,505 | 553,100 | -478,405 | 0.01 | 0.00 | -0.00 | sell |
| GCM Grosvenor Holdings, LLC | 495,916 | 495,916 | 0 | 0.24 | 0.26 | +0.03 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,019,987 | 459,565 | -560,422 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 122,888 | 424,277 | +301,389 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 164,356 | 404,279 | +239,923 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 548,544 | 362,619 | -185,925 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 356,101 | 356,601 | +500 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 355,225 | 353,771 | -1,454 | 0.06 | 0.06 | -0.00 | sell |
| Bruce & Co., Inc. | 300,000 | 350,000 | +50,000 | 0.32 | 0.36 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 345,575 | 345,575 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Bank of New York Mellon Corp | 374,132 | 299,286 | -74,846 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 446,668 | 270,616 | -176,052 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 242,432 | 249,742 | +7,310 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 181,089 | 227,981 | +46,892 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 250,793 | 214,425 | -36,368 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 59,026 | 209,144 | +150,118 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 166,255 | 185,409 | +19,154 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 12,372 | 174,148 | +161,776 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 179,100 | 166,700 | -12,400 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 167,055 | 163,104 | -3,951 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 160,001 | 156,998 | -3,003 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 229,863 | 150,821 | -79,042 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 217,739 | 147,872 | -69,867 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 146,580 | 146,580 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 188,460 | 142,131 | -46,329 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 28,652 | 138,339 | +109,687 | 0.02 | 0.11 | +0.09 | buy |
| Monaco Asset Management SAM | 286,900 | 137,671 | -149,229 | 0.47 | 0.20 | -0.27 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 139,366 | 134,866 | -4,500 | 0.00 | 0.00 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 100,566 | 125,370 | +24,804 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 102,096 | 101,878 | -218 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 88,514 | 89,716 | +1,202 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 89,330 | 89,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,653 | 81,778 | -7,875 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 80,670 | +80,670 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 47,869 | 74,205 | +26,336 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 77,816 | 71,101 | -6,715 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 18,600 | 67,609 | +49,009 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 65,611 | 65,611 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 65,219 | 65,219 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 102,295 | 63,903 | -38,392 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 51,744 | 63,264 | +11,520 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 101,933 | 62,870 | -39,063 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 57,252 | 59,111 | +1,859 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,293 | 56,761 | +3,468 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 33,453 | 55,663 | +22,210 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 53,859 | 53,529 | -330 | 0.00 | 0.00 | +0.00 | sell |
| Privium Fund Management B.V. | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| TUDOR INVESTMENT CORP ET AL | 45,290 | 48,169 | +2,879 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 58,365 | 46,631 | -11,734 | 0.03 | 0.02 | -0.01 | sell |
| CANADA LIFE ASSURANCE Co | 42,166 | 45,632 | +3,466 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 46,528 | 42,652 | -3,876 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 59,989 | 42,652 | -17,337 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 30,059 | 42,289 | +12,230 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 39,715 | 38,464 | -1,251 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 34,797 | 34,797 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 36,372 | 34,363 | -2,009 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 33,254 | 33,434 | +180 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 32,098 | +32,098 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 30,946 | +30,946 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 29,649 | 29,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 28,016 | 28,016 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,015 | 28,015 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parcion Private Wealth LLC | 28,000 | 28,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 19,065 | 26,849 | +7,784 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 25,486 | 24,583 | -903 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 41,487 | 24,096 | -17,391 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 16,460 | 24,084 | +7,624 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 23,906 | 23,653 | -253 | 0.00 | 0.00 | +0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 19,999 | 21,430 | +1,431 | 0.00 | 0.00 | -0.00 | buy |
| Castleview Partners, LLC | 0 | 20,826 | +20,826 | 0.00 | 0.04 | +0.04 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 43,472 | 20,683 | -22,789 | 0.02 | 0.02 | -0.00 | sell |