| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 73,401 | 3,489,163 | +3,415,762 | 0.00 | 0.04 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,700,000 | +1,700,000 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 900,000 | +900,000 | 0.00 | 0.49 | +0.49 | buy |
| CITIGROUP INC | 8,717 | 843,962 | +835,245 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,019,632 | 2,666,208 | +646,576 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 528,080 | +528,080 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 19,200 | 497,457 | +478,257 | 0.00 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 192,072 | 607,004 | +414,932 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 385,364 | +385,364 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 194,911 | 560,011 | +365,100 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 1,847,944 | 2,183,228 | +335,284 | 1.96 | 3.14 | +1.18 | buy |
| Man Group plc | 0 | 252,676 | +252,676 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 118,751 | 359,375 | +240,624 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,389,123 | 2,616,820 | +227,697 | 0.03 | 0.05 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 34,802 | 214,345 | +179,543 | 0.00 | 0.01 | +0.01 | buy |
| Pennant Investors, LP | 0 | 146,100 | +146,100 | 0.00 | 0.17 | +0.17 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,149,597 | 2,281,171 | +131,574 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 66,710 | 176,305 | +109,595 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 494,466 | 590,993 | +96,527 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 886,715 | 983,019 | +96,304 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 89,162 | +89,162 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,775,344 | 1,863,485 | +88,141 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 14,259 | 94,501 | +80,242 | 0.01 | 0.07 | +0.06 | buy |
| ROYCE & ASSOCIATES LP | 30,339 | 107,318 | +76,979 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 174,481 | 233,748 | +59,267 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 13,124,427 | 13,169,057 | +44,630 | 1.32 | 1.76 | +0.44 | buy |
| Cerity Partners LLC | 0 | 32,174 | +32,174 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 15,387 | 46,847 | +31,460 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 17,337 | 38,230 | +20,893 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 18,066 | +18,066 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 73,642 | 90,553 | +16,911 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 47,566 | 63,725 | +16,159 | 0.00 | 0.01 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 16,092 | 32,184 | +16,092 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 37,062 | 52,982 | +15,920 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,440 | 16,840 | +15,400 | 0.00 | 0.00 | +0.00 | buy |
| RPO LLC | 0 | 12,307 | +12,307 | 0.00 | 0.07 | +0.07 | buy |
| ExodusPoint Capital Management, LP | 19,031 | 31,185 | +12,154 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 81,821 | 93,313 | +11,492 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 10,637 | +10,637 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 6,289 | 16,689 | +10,400 | 0.00 | 0.00 | +0.00 | buy |
| EPIQ PARTNERS, LLC | 0 | 10,071 | +10,071 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 312,788 | 321,952 | +9,164 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,405 | 7,991 | +5,586 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 4,362 | +4,362 | 0.00 | 0.00 | +0.00 | buy |
| Wilshire Advisors LLC | 0 | 4,083 | +4,083 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 34,305 | 38,340 | +4,035 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 125,587 | 129,454 | +3,867 | 0.00 | 0.00 | +0.00 | buy |
| Dunhill Financial, LLC | 0 | 3,180 | +3,180 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,182 | 12,504 | +2,322 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 319 | 1,449 | +1,130 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 14,806 | 15,531 | +725 | 0.01 | 0.01 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 682 | +682 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 529 | +529 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 408 | +408 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 369 | +369 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 10,541 | 10,811 | +270 | 0.00 | 0.00 | -0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 260 | +260 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 19 | 43 | +24 | 0.00 | 0.00 | 0.00 | buy |
| RESOURCES MANAGEMENT CORP /CT/ /ADV | 0 | 16 | +16 | 0.00 | 0.00 | 0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 154,178 | 154,178 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALBION FINANCIAL GROUP /UT | 225 | 225 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 8,358 | 8,358 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 41,337 | 41,337 | 0 | 0.02 | 0.03 | +0.01 | hold |
| BOURGEON CAPITAL MANAGEMENT LLC | 175 | 175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 0.21 | 0.24 | +0.03 | hold |
| BROWN ADVISORY INC | 19,364 | 19,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORGES BANK | 42,672 | 42,672 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AdvisorNet Financial, Inc | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Asset Dedication, LLC | 55 | 55 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Diversified Trust Co | 12,287 | 12,287 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 44,004 | 44,004 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 2,050,000 | 2,050,000 | 0 | 0.48 | 0.76 | +0.27 | hold |
| Parametrica Management Ltd | 18,472 | 18,472 | 0 | 0.07 | 0.11 | +0.05 | hold |
| Allworth Financial LP | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Grassi Investment Management | 18,000 | 18,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| IFP Advisors, Inc | 3,360 | 3,360 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bellevue Group AG | 4,851,579 | 4,851,579 | 0 | 0.17 | 0.28 | +0.11 | hold |
| Providence Capital Advisors, LLC | 61 | 61 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parcion Private Wealth LLC | 28,000 | 28,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Eagle Bay Advisors LLC | 76 | 76 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HERBST GROUP, LLC | 15,700 | 15,700 | 0 | 0.02 | 0.04 | +0.01 | hold |
| GCM Grosvenor Holdings, LLC | 495,916 | 495,916 | 0 | 0.21 | 0.33 | +0.12 | hold |
| UniSuper Management Pty Ltd | 7,350 | 7,350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JOHNSON & JOHNSON | 3,379,064 | 3,379,064 | 0 | 2.64 | 0.29 | -2.35 | hold |
| Federation des caisses Desjardins du Quebec | 95 | 95 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 140,342 | 140,335 | -7 | 0.00 | 0.00 | +0.00 | sell |
| Newbridge Financial Services Group, Inc. | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 16,546 | 16,511 | -35 | 0.00 | 0.00 | +0.00 | sell |
| Glassman Wealth Services | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| CARY STREET PARTNERS INVESTMENT ADVISORY LLC | 85 | 0 | -85 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,193 | 28,025 | -168 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 42,297 | 42,126 | -171 | 0.00 | 0.00 | +0.00 | sell |
| Avion Wealth | 179 | 0 | -179 | 0.00 | 0.00 | 0.00 | sell |
| Daiwa Securities Group Inc. | 360 | 0 | -360 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 984 | 360 | -624 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 10,276 | 9,600 | -676 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 161,560 | 160,760 | -800 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 8,314 | 7,447 | -867 | 0.00 | 0.00 | +0.00 | sell |