| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 13,169,057 | 12,872,946 | -296,111 | 2.72 | 1.48 | -1.24 | sell |
| BlackRock, Inc. | 10,473,250 | 10,941,582 | +468,332 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 10,404,123 | 10,333,033 | -71,090 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 4,839,779 | 4,839,779 | 0 | 0.27 | 0.15 | -0.12 | hold |
| CITADEL ADVISORS LLC | 4,282,077 | 4,382,257 | +100,180 | 0.02 | 0.01 | -0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,555,871 | 3,555,871 | 0 | 0.19 | 0.11 | -0.07 | hold |
| JOHNSON & JOHNSON | 3,379,064 | 3,379,064 | 0 | 2.77 | 1.44 | -1.32 | hold |
| BAKER BROS. ADVISORS LP | 2,997,772 | 3,258,402 | +260,630 | 0.11 | 0.06 | -0.05 | buy |
| EcoR1 Capital, LLC | 0 | 3,049,405 | +3,049,405 | 0.00 | 0.20 | +0.20 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,619,017 | 2,898,377 | +279,360 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 3,063,421 | 2,822,183 | -241,238 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,823,403 | 2,476,414 | -346,989 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 1,685,000 | 2,465,000 | +780,000 | 0.47 | 0.24 | -0.22 | buy |
| STATE STREET CORP | 5,252,974 | 2,227,295 | -3,025,679 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,258,246 | 2,226,967 | -31,279 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 1,855,954 | +1,155,954 | 0.18 | 0.20 | +0.03 | buy |
| ORBIMED ADVISORS LLC | 1,680,580 | 1,680,580 | 0 | 0.11 | 0.06 | -0.05 | hold |
| JPMORGAN CHASE & CO | 1,837,304 | 1,669,562 | -167,742 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,587,900 | 1,586,987 | -913 | 0.02 | 0.01 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 3,377,650 | 1,536,633 | -1,841,017 | 0.02 | 0.00 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,602,120 | 1,473,792 | -128,328 | 0.02 | 0.01 | -0.01 | sell |
| Woodline Partners LP | 3,065,747 | 1,422,785 | -1,642,962 | 0.09 | 0.02 | -0.07 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,466,934 | 1,379,556 | -87,378 | 4.59 | 2.00 | -2.59 | sell |
| UBS Group AG | 404,279 | 1,103,393 | +699,114 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 67,609 | 1,083,092 | +1,015,483 | 0.00 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 927,240 | 828,100 | -99,140 | 0.01 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 16,288 | 823,134 | +806,846 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 815,160 | 805,518 | -9,642 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 74,205 | 781,889 | +707,684 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 763,808 | 770,280 | +6,472 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 975,000 | 600,000 | -375,000 | 0.40 | 0.09 | -0.31 | sell |
| FEDERATED HERMES, INC. | 553,100 | 543,021 | -10,079 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 512,641 | +512,641 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 424,277 | 416,731 | -7,546 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 270,616 | 413,192 | +142,576 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 397,177 | +397,177 | 0.00 | 0.12 | +0.12 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 362,619 | 378,619 | +16,000 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 2,434,198 | 372,507 | -2,061,691 | 0.02 | 0.00 | -0.02 | sell |
| FMR LLC | 227,981 | 356,964 | +128,983 | 0.00 | 0.00 | -0.00 | buy |
| Bruce & Co., Inc. | 350,000 | 350,000 | 0 | 0.36 | 0.19 | -0.17 | hold |
| E Fund Management Co., Ltd. | 353,771 | 339,994 | -13,777 | 0.06 | 0.03 | -0.04 | sell |
| Monaco Asset Management SAM | 137,671 | 327,671 | +190,000 | 0.20 | 0.24 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 356,601 | 321,401 | -35,200 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 854,195 | 304,129 | -550,066 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 459,565 | 297,106 | -162,459 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 299,286 | 293,006 | -6,280 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 174,148 | 287,711 | +113,563 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 249,800 | +249,800 | 0.00 | 0.03 | +0.03 | buy |
| BIT Capital GmbH | 0 | 247,564 | +247,564 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 185,409 | 197,704 | +12,295 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 249,742 | 177,161 | -72,581 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 150,821 | 165,353 | +14,532 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 156,998 | 159,172 | +2,174 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,084 | 147,602 | +123,518 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 146,580 | 146,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 262,414 | 118,186 | -144,228 | 0.02 | 0.00 | -0.02 | sell |
| HSBC HOLDINGS PLC | 89,716 | 109,422 | +19,706 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 101,878 | 108,934 | +7,056 | 0.00 | 0.00 | -0.00 | buy |
| Aristides Capital LLC | 0 | 100,555 | +100,555 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 59,111 | 92,395 | +33,284 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 62,870 | 89,823 | +26,953 | 0.00 | 0.00 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 125,370 | 89,322 | -36,048 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 134,866 | 88,766 | -46,100 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 50,000 | 87,000 | +37,000 | 0.04 | 0.03 | -0.01 | buy |
| LPL Financial LLC | 0 | 73,120 | +73,120 | 0.00 | 0.00 | +0.00 | buy |
| Leo Wealth, LLC | 10,439 | 70,439 | +60,000 | 0.00 | 0.01 | +0.01 | buy |
| Institute for Wealth Management, LLC. | 0 | 66,886 | +66,886 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 65,611 | 65,510 | -101 | 0.01 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 26,849 | 61,220 | +34,371 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 63,264 | 57,281 | -5,983 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 53,585 | +53,585 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 53,529 | 49,772 | -3,757 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 34,363 | 44,874 | +10,511 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 42,289 | 42,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 30,946 | 39,443 | +8,497 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,464 | 38,403 | -61 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 65,219 | 38,049 | -27,170 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 35,360 | +35,360 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 13,490 | 34,295 | +20,805 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 18,917 | 33,645 | +14,728 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 33,094 | +33,094 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 31,682 | +31,682 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,434 | 31,259 | -2,175 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 29,649 | 29,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 209,144 | 29,173 | -179,971 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 28,016 | 28,016 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,015 | 28,015 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parcion Private Wealth LLC | 28,000 | 28,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 26,533 | +26,533 | 0.00 | 0.00 | +0.00 | buy |
| FPC INVESTMENT ADVISORY, INC. | 0 | 26,456 | +26,456 | 0.00 | 0.03 | +0.03 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 32,098 | 25,580 | -6,518 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 24,636 | +24,636 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 23,653 | 24,193 | +540 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 24,150 | +24,150 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 22,342 | +22,342 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 45,632 | 21,267 | -24,365 | 0.00 | 0.00 | -0.00 | sell |
| Castleview Partners, LLC | 20,826 | 19,279 | -1,547 | 0.04 | 0.02 | -0.02 | sell |
| Parametrica Management Ltd | 18,472 | 18,472 | 0 | 0.08 | 0.04 | -0.04 | hold |
| Grassi Investment Management | 18,000 | 18,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 17,151 | 17,135 | -16 | 0.00 | 0.00 | -0.00 | sell |