| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 3,049,405 | +3,049,405 | 0.00 | 0.20 | +0.20 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 1,855,954 | +1,155,954 | 0.18 | 0.20 | +0.03 | buy |
| Walleye Capital LLC | 67,609 | 1,083,092 | +1,015,483 | 0.00 | 0.02 | +0.01 | buy |
| Cerity Partners LLC | 16,288 | 823,134 | +806,846 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 1,685,000 | 2,465,000 | +780,000 | 0.47 | 0.24 | -0.22 | buy |
| CITIGROUP INC | 74,205 | 781,889 | +707,684 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 404,279 | 1,103,393 | +699,114 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 512,641 | +512,641 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 10,473,250 | 10,941,582 | +468,332 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 397,177 | +397,177 | 0.00 | 0.12 | +0.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,619,017 | 2,898,377 | +279,360 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,997,772 | 3,258,402 | +260,630 | 0.11 | 0.06 | -0.05 | buy |
| XTX Topco Ltd | 0 | 249,800 | +249,800 | 0.00 | 0.03 | +0.03 | buy |
| BIT Capital GmbH | 0 | 247,564 | +247,564 | 0.00 | 0.04 | +0.04 | buy |
| Monaco Asset Management SAM | 137,671 | 327,671 | +190,000 | 0.20 | 0.24 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 270,616 | 413,192 | +142,576 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 227,981 | 356,964 | +128,983 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,084 | 147,602 | +123,518 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 174,148 | 287,711 | +113,563 | 0.00 | 0.00 | -0.00 | buy |
| Aristides Capital LLC | 0 | 100,555 | +100,555 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 4,282,077 | 4,382,257 | +100,180 | 0.02 | 0.01 | -0.01 | buy |
| LPL Financial LLC | 0 | 73,120 | +73,120 | 0.00 | 0.00 | +0.00 | buy |
| Institute for Wealth Management, LLC. | 0 | 66,886 | +66,886 | 0.00 | 0.01 | +0.01 | buy |
| Leo Wealth, LLC | 10,439 | 70,439 | +60,000 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 53,585 | +53,585 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 50,000 | 87,000 | +37,000 | 0.04 | 0.03 | -0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 35,360 | +35,360 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 26,849 | 61,220 | +34,371 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,111 | 92,395 | +33,284 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 33,094 | +33,094 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 31,682 | +31,682 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 62,870 | 89,823 | +26,953 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 26,533 | +26,533 | 0.00 | 0.00 | +0.00 | buy |
| FPC INVESTMENT ADVISORY, INC. | 0 | 26,456 | +26,456 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 24,636 | +24,636 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 24,150 | +24,150 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 22,342 | +22,342 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 13,490 | 34,295 | +20,805 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 89,716 | 109,422 | +19,706 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 362,619 | 378,619 | +16,000 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 18,917 | 33,645 | +14,728 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 150,821 | 165,353 | +14,532 | 0.00 | 0.00 | -0.00 | buy |
| RPO LLC | 0 | 14,222 | +14,222 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,633 | +13,633 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 185,409 | 197,704 | +12,295 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 10,666 | +10,666 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 34,363 | 44,874 | +10,511 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 30,946 | 39,443 | +8,497 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,885 | 14,728 | +7,843 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 7,776 | +7,776 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 101,878 | 108,934 | +7,056 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 2,117 | 8,728 | +6,611 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 763,808 | 770,280 | +6,472 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 5,430 | +5,430 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 3,795 | +3,795 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 868 | 4,145 | +3,277 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 352 | 3,400 | +3,048 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 156,998 | 159,172 | +2,174 | 0.00 | 0.00 | -0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 1,761 | 3,585 | +1,824 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 900 | +900 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 13,951 | 14,772 | +821 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 570 | +570 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 23,653 | 24,193 | +540 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,078 | 12,117 | +39 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 70 | +30 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 13 | 31 | +18 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,555,871 | 3,555,871 | 0 | 0.19 | 0.11 | -0.07 | hold |
| ALBION FINANCIAL GROUP /UT | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 1,680,580 | 1,680,580 | 0 | 0.11 | 0.06 | -0.05 | hold |
| Ameritas Investment Partners, Inc. | 8,358 | 8,358 | 0 | 0.00 | 0.00 | -0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 146,580 | 146,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 255 | 255 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHELL ASSET MANAGEMENT CO | 1 | 1 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Bruce & Co., Inc. | 350,000 | 350,000 | 0 | 0.36 | 0.19 | -0.17 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 42,289 | 42,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parametrica Management Ltd | 18,472 | 18,472 | 0 | 0.08 | 0.04 | -0.04 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Grassi Investment Management | 18,000 | 18,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Wilshire Advisors LLC | 4,083 | 4,083 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bellevue Group AG | 4,839,779 | 4,839,779 | 0 | 0.27 | 0.15 | -0.12 | hold |
| EverSource Wealth Advisors, LLC | 682 | 682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parcion Private Wealth LLC | 28,000 | 28,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Eagle Bay Advisors LLC | 76 | 76 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bell Investment Advisors, Inc | 260 | 260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corient Private Wealth LLC | 29,649 | 29,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dunhill Financial, LLC | 3,180 | 3,180 | 0 | 0.01 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 3,379,064 | 3,379,064 | 0 | 2.77 | 1.44 | -1.32 | hold |
| Caitlin John, LLC | 92 | 92 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hilltop National Bank | 285 | 285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 95 | 95 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legacy Investment Solutions, LLC | 115 | 115 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legacy Wealth Managment, LLC/ID | 115 | 115 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,015 | 28,015 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,912 | 2,912 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 28,016 | 28,016 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 17,151 | 17,135 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 41 | 4 | -37 | 0.00 | 0.00 | -0.00 | sell |