| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 12,872,946 | 12,872,946 | 0 | 1.58 | 0.93 | -0.65 | hold |
| BlackRock, Inc. | 10,680,727 | 10,176,487 | -504,240 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 8,798,491 | 8,971,347 | +172,856 | 0.00 | 0.00 | -0.00 | buy |
| JOHNSON & JOHNSON | 3,379,064 | 3,379,064 | 0 | 0.84 | 0.60 | -0.25 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 2,710,234 | 2,931,893 | +221,659 | 0.01 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,530,212 | 2,468,348 | -61,864 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,262,515 | 2,360,881 | +1,098,366 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,417,135 | 2,265,217 | -151,918 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 900,757 | 1,734,064 | +833,307 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 2,515,000 | 1,725,000 | -790,000 | 0.14 | 0.06 | -0.08 | sell |
| TWO SIGMA ADVISERS, LP | 1,007,400 | 1,651,700 | +644,300 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,094,975 | 1,577,478 | -517,497 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 1,527,986 | +1,527,986 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,486,407 | 1,435,040 | -51,367 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,867,773 | 1,167,773 | -700,000 | 0.09 | 0.06 | -0.03 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,131,414 | 1,162,005 | +30,591 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 603,761 | 842,807 | +239,046 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 770,000 | 830,000 | +60,000 | 0.36 | 0.24 | -0.12 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 785,921 | 784,628 | -1,293 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 824,545 | 749,336 | -75,209 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 814,465 | 732,670 | -81,795 | 0.00 | 0.00 | -0.00 | sell |
| Bruce & Co., Inc. | 729,188 | 729,188 | 0 | 0.28 | 0.22 | -0.06 | hold |
| DAFNA Capital Management LLC | 0 | 550,000 | +550,000 | 0.00 | 0.13 | +0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 963,871 | 522,617 | -441,254 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 314,759 | 403,524 | +88,765 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 314,825 | 379,025 | +64,200 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 333,219 | 369,100 | +35,881 | 0.08 | 0.07 | -0.01 | buy |
| Knott David M Jr | 365,000 | 365,000 | 0 | 0.19 | 0.17 | -0.03 | hold |
| XTX Topco Ltd | 437,918 | 364,738 | -73,180 | 0.03 | 0.01 | -0.02 | sell |
| Woodline Partners LP | 712,650 | 356,650 | -356,000 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 336,872 | 336,872 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,927 | 310,191 | +131,264 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 210,487 | 308,542 | +98,055 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 316,336 | 307,597 | -8,739 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 377,357 | 298,082 | -79,275 | 0.01 | 0.00 | -0.00 | sell |
| Man Group plc | 219,658 | 261,172 | +41,514 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 310,826 | 213,645 | -97,181 | 0.03 | 0.02 | -0.01 | sell |
| Graham Capital Management, L.P. | 469,071 | 195,579 | -273,492 | 0.02 | 0.01 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 544,587 | 192,682 | -351,905 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 187,700 | 187,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 133,839 | 172,283 | +38,444 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 145,838 | 148,653 | +2,815 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 154,086 | 146,761 | -7,325 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 100,000 | 135,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 137,561 | 121,501 | -16,060 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 111,227 | +111,227 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 97,802 | 97,684 | -118 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 95,185 | 95,185 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 157,159 | 91,679 | -65,480 | 0.00 | 0.00 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 0 | 90,000 | +90,000 | 0.00 | 0.00 | +0.00 | buy |
| Leo Wealth, LLC | 70,439 | 70,439 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Shay Capital LLC | 0 | 70,000 | +70,000 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 68,871 | +68,871 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 67,721 | 67,643 | -78 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 54,470 | 54,470 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cerity Partners LLC | 50,817 | 52,489 | +1,672 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,672 | 52,373 | +1,701 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 66,093 | 51,789 | -14,304 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 56,316 | 51,660 | -4,656 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 64,243 | 50,947 | -13,296 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 60,877 | 48,544 | -12,333 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 14,900 | 38,913 | +24,013 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 35,658 | +35,658 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 38,743 | 34,925 | -3,818 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 34,105 | 34,105 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighTower Advisors, LLC | 37,200 | 32,219 | -4,981 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 12,138 | 31,966 | +19,828 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 0 | 29,830 | +29,830 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 27,356 | 29,295 | +1,939 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,015 | 28,015 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 10,574 | 27,459 | +16,885 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 26,548 | +26,548 | 0.00 | 0.00 | +0.00 | buy |
| FPC INVESTMENT ADVISORY, INC. | 26,456 | 26,456 | 0 | 0.02 | 0.01 | -0.01 | hold |
| CAPTRUST FINANCIAL ADVISORS | 19,489 | 25,534 | +6,045 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 29,674 | 24,419 | -5,255 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 26,294 | 23,891 | -2,403 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 43,191 | 23,160 | -20,031 | 0.00 | 0.00 | -0.00 | sell |
| Bronte Capital Management Pty Ltd. | 0 | 22,853 | +22,853 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 22,502 | 22,502 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 20,768 | 20,768 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quinn Opportunity Partners LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 22,703 | 19,872 | -2,831 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 0 | 19,445 | +19,445 | 0.00 | 0.00 | +0.00 | buy |
| Parametrica Management Ltd | 18,472 | 18,472 | 0 | 0.04 | 0.03 | -0.01 | hold |
| TIAA TRUST, NATIONAL ASSOCIATION | 17,592 | 17,592 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 22,930 | 14,889 | -8,041 | 0.00 | 0.00 | -0.00 | sell |
| Pallas Capital Advisors LLC | 16,759 | 14,674 | -2,085 | 0.00 | 0.00 | -0.00 | sell |
| Parcion Private Wealth LLC | 14,469 | 14,057 | -412 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 0 | 13,950 | +13,950 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 16,377 | 13,918 | -2,459 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 10,484 | 12,756 | +2,272 | 0.00 | 0.00 | -0.00 | buy |
| Narwhal Capital Management | 12,700 | 12,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaCore Capital LLC | 0 | 12,689 | +12,689 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,600 | 12,628 | +28 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 11,937 | 11,029 | -908 | 0.00 | 0.00 | -0.00 | sell |
| HBK Sorce Advisory LLC | 11,620 | 10,659 | -961 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 17,929 | 10,458 | -7,471 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 10,398 | 10,398 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Westmount Partners, LLC | 10,098 | 10,098 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 28,676 | 9,300 | -19,376 | 0.00 | 0.00 | -0.00 | sell |