| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 4,081,544 | 4,037,154 | -44,390 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 4,615,676 | 3,476,143 | -1,139,533 | 0.21 | 0.16 | -0.06 | sell |
| VANGUARD GROUP INC | 2,952,686 | 3,083,362 | +130,676 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,168,000 | 2,225,000 | -1,943,000 | 0.06 | 0.03 | -0.03 | sell |
| Nantahala Capital Management, LLC | 1,471,936 | 1,971,936 | +500,000 | 0.92 | 1.16 | +0.24 | buy |
| FMR LLC | 2,289,243 | 1,634,571 | -654,672 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,241,658 | 1,427,291 | +185,633 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,242,386 | 1,300,340 | +57,954 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 918,893 | 1,231,932 | +313,039 | 3.80 | 4.10 | +0.30 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,493 | 1,205,514 | +1,044,021 | 0.00 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 935,677 | 1,053,399 | +117,722 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 634,820 | 1,035,251 | +400,431 | 0.01 | 0.01 | +0.00 | buy |
| 683 Capital Management, LLC | 1,125,000 | 975,000 | -150,000 | 1.01 | 0.84 | -0.16 | sell |
| MARSHALL WACE, LLP | 0 | 912,299 | +912,299 | 0.00 | 0.01 | +0.01 | buy |
| Stonepine Capital Management, LLC | 775,620 | 810,000 | +34,380 | 6.73 | 6.26 | -0.47 | buy |
| GOLDMAN SACHS GROUP INC | 374,792 | 761,777 | +386,985 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 189,313 | 725,830 | +536,517 | 0.00 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 691,239 | +691,239 | 0.00 | 0.07 | +0.07 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 450,000 | 650,000 | +200,000 | 0.77 | 0.97 | +0.20 | buy |
| Retirement Planning Co of New England, Inc. | 553,297 | 600,770 | +47,473 | 2.17 | 2.30 | +0.13 | buy |
| MORGAN STANLEY | 213,088 | 555,950 | +342,862 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 510,091 | +510,091 | 0.00 | 0.28 | +0.28 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 447,896 | +447,896 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 425,119 | 439,480 | +14,361 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 28,161 | 438,984 | +410,823 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 418,550 | +418,550 | 0.00 | 0.07 | +0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 315,469 | 412,547 | +97,078 | 0.00 | 0.00 | +0.00 | buy |
| Mystic Asset Management, Inc. | 346,652 | 346,652 | 0 | 0.74 | 0.74 | +0.01 | hold |
| BARCLAYS PLC | 104,351 | 332,443 | +228,092 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 11,288 | 306,489 | +295,201 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 302,863 | +302,863 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 223,852 | 288,045 | +64,193 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 268,077 | +268,077 | 0.00 | 0.01 | +0.01 | buy |
| Propel Bio Management, LLC | 231,874 | 231,874 | 0 | 2.48 | 2.21 | -0.27 | hold |
| Stratos Wealth Partners, LTD. | 220,000 | 229,000 | +9,000 | 0.03 | 0.03 | -0.00 | buy |
| UBS Group AG | 154,184 | 218,096 | +63,912 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 148,904 | 214,202 | +65,298 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 193,509 | +193,509 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 114,267 | 191,796 | +77,529 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 146,284 | 187,266 | +40,982 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 256,664 | 183,701 | -72,963 | 0.01 | 0.00 | -0.00 | sell |
| Kovack Advisors, Inc. | 146,788 | 175,283 | +28,495 | 0.13 | 0.16 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,967 | 157,765 | -4,202 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 143,132 | 153,032 | +9,900 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 152,311 | +152,311 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 147,000 | 147,000 | 0 | 0.08 | 0.03 | -0.05 | hold |
| Brevan Howard Capital Management LP | 0 | 130,751 | +130,751 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 118,975 | 125,831 | +6,856 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 20,001 | 117,576 | +97,575 | 0.00 | 0.02 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 81,570 | +81,570 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 83,221 | 77,489 | -5,732 | 0.00 | 0.00 | -0.00 | sell |
| Arete Wealth Advisors, LLC | 74,789 | 74,279 | -510 | 0.05 | 0.04 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 70,300 | 70,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 0 | 67,485 | +67,485 | 0.00 | 0.00 | +0.00 | buy |
| PharVision Advisers, LLC | 0 | 66,733 | +66,733 | 0.00 | 0.36 | +0.36 | buy |
| XTX Topco Ltd | 0 | 66,381 | +66,381 | 0.00 | 0.03 | +0.03 | buy |
| Virtu Financial LLC | 0 | 62,740 | +62,740 | 0.00 | 0.03 | +0.03 | buy |
| Quantbot Technologies LP | 28,992 | 62,646 | +33,654 | 0.01 | 0.02 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 121,225 | 58,540 | -62,685 | 0.00 | 0.00 | -0.00 | sell |
| CARRET ASSET MANAGEMENT, LLC | 39,640 | 57,040 | +17,400 | 0.04 | 0.05 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 54,397 | +54,397 | 0.00 | 0.04 | +0.04 | buy |
| GROUP ONE TRADING LLC | 0 | 52,638 | +52,638 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 51,049 | +51,049 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 38,470 | 44,003 | +5,533 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 43,026 | +43,026 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 41,452 | +41,452 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 40,705 | +40,705 | 0.00 | 0.01 | +0.01 | buy |
| DLD Asset Management, LP | 0 | 40,000 | +40,000 | 0.00 | 0.05 | +0.05 | buy |
| Campbell & CO Investment Adviser LLC | 83,245 | 37,631 | -45,614 | 0.05 | 0.03 | -0.02 | sell |
| WELLS FARGO & COMPANY/MN | 29,853 | 36,856 | +7,003 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 36,835 | +36,835 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 35,661 | +35,661 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 33,652 | +33,652 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 16,732 | 31,698 | +14,966 | 0.02 | 0.04 | +0.02 | buy |
| Invesco Ltd. | 19,744 | 31,535 | +11,791 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 11,251 | 31,021 | +19,770 | 0.02 | 0.05 | +0.03 | buy |
| IFG Advisors, LLC | 29,050 | 29,050 | 0 | 0.04 | 0.05 | +0.00 | hold |
| EntryPoint Capital, LLC | 0 | 28,882 | +28,882 | 0.00 | 0.11 | +0.11 | buy |
| Aquatic Capital Management LLC | 32,298 | 28,593 | -3,705 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,690 | 28,492 | +2,802 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 27,980 | +27,980 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 31,334 | 25,943 | -5,391 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 25,328 | +25,328 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 32,682 | 25,214 | -7,468 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,260 | 24,896 | -5,364 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 26,916 | 23,306 | -3,610 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 22,826 | +22,826 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 4,000 | 22,338 | +18,338 | 0.00 | 0.00 | +0.00 | buy |
| STONERIDGE INVESTMENT PARTNERS LLC | 0 | 21,129 | +21,129 | 0.00 | 0.14 | +0.14 | buy |
| OMERS ADMINISTRATION Corp | 0 | 21,100 | +21,100 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,592 | 20,895 | -4,697 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 0 | 20,499 | +20,499 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 824 | 19,914 | +19,090 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,294 | 18,664 | -1,630 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 60,134 | 17,522 | -42,612 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON ASSOCIATES LLP | 0 | 17,317 | +17,317 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 17,190 | +17,190 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 15,600 | +15,600 | 0.00 | 0.01 | +0.01 | buy |
| City State Bank | 16,224 | 15,478 | -746 | 0.04 | 0.04 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 0 | 15,081 | +15,081 | 0.00 | 0.00 | +0.00 | buy |