| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10,511,166 | 11,419,586 | +908,420 | 0.18 | 0.16 | -0.02 | buy |
| FMR LLC | 9,617,863 | 10,967,967 | +1,350,104 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 7,869,352 | 7,792,033 | -77,319 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 4,756,666 | 4,959,988 | +203,322 | 0.01 | 0.01 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 3,763,891 | 4,897,417 | +1,133,526 | 3.52 | 4.80 | +1.28 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 4,779,000 | +4,779,000 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 4,278,180 | 4,142,551 | -135,629 | 2.99 | 2.43 | -0.56 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,143,495 | 2,369,559 | +226,064 | 0.01 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,246,779 | 1,966,779 | -280,000 | 0.13 | 0.09 | -0.04 | sell |
| Stephens Investment Management Group LLC | 1,721,623 | 1,798,466 | +76,843 | 0.86 | 0.73 | -0.12 | buy |
| GOLDMAN SACHS GROUP INC | 1,868,212 | 1,719,721 | -148,491 | 0.01 | 0.01 | -0.00 | sell |
| Kynam Capital Management, LP | 517,884 | 1,569,018 | +1,051,134 | 1.29 | 2.96 | +1.67 | buy |
| EMERALD ADVISERS, LLC | 1,594,184 | 1,557,196 | -36,988 | 1.88 | 1.46 | -0.41 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,156,807 | 1,508,259 | +351,452 | 0.07 | 0.04 | -0.03 | buy |
| Rock Springs Capital Management LP | 2,210,322 | 1,477,954 | -732,368 | 4.33 | 2.59 | -1.75 | sell |
| BANK OF AMERICA CORP /DE/ | 1,850,355 | 1,345,111 | -505,244 | 0.01 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 901,404 | 1,282,518 | +381,114 | 0.23 | 0.28 | +0.05 | buy |
| MPM BioImpact LLC | 0 | 1,133,365 | +1,133,365 | 0.00 | 2.60 | +2.60 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 798,984 | 1,022,272 | +223,288 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,927,000 | 977,000 | -1,950,000 | 0.17 | 0.04 | -0.12 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 948,459 | 945,033 | -3,426 | 1.77 | 1.36 | -0.40 | sell |
| Nuveen, LLC | 993,613 | 938,569 | -55,044 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 881,680 | 925,919 | +44,239 | 0.01 | 0.01 | -0.00 | buy |
| Fiera Capital Corp | 874,053 | 900,868 | +26,815 | 0.11 | 0.09 | -0.01 | buy |
| UBS Group AG | 422,619 | 856,757 | +434,138 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,094,556 | 836,544 | -258,012 | 0.03 | 0.02 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 808,189 | 790,812 | -17,377 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 761,473 | 781,418 | +19,945 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 746,841 | +746,841 | 0.00 | 0.24 | +0.24 | buy |
| Ensign Peak Advisors, Inc | 805,215 | 715,707 | -89,508 | 0.05 | 0.04 | -0.01 | sell |
| Qube Research & Technologies Ltd | 406,221 | 669,159 | +262,938 | 0.02 | 0.03 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 587,354 | 592,912 | +5,558 | 0.08 | 0.07 | -0.01 | buy |
| Aberdeen Group plc | 518,357 | 557,147 | +38,790 | 0.03 | 0.03 | -0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 546,000 | +546,000 | 0.00 | 0.66 | +0.66 | buy |
| Eversept Partners, LP | 1,174,968 | 542,610 | -632,358 | 2.52 | 1.06 | -1.46 | sell |
| Pictet Asset Management Holding SA | 534,614 | 529,757 | -4,857 | 0.02 | 0.02 | -0.00 | sell |
| Invesco Ltd. | 474,075 | 523,711 | +49,636 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 520,604 | +520,604 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 536,925 | 451,056 | -85,869 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 394,844 | 404,805 | +9,961 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 396,853 | +396,853 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 468,556 | 369,995 | -98,561 | 0.09 | 0.06 | -0.03 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 268,926 | 369,193 | +100,267 | 0.04 | 0.05 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 352,717 | 305,412 | -47,305 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 164,264 | 302,666 | +138,402 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 392,273 | 302,280 | -89,993 | 0.02 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 1,415,897 | 301,655 | -1,114,242 | 0.00 | 0.00 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 238,924 | 301,466 | +62,542 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 300,000 | 0 | 0.82 | 0.52 | -0.30 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 249,557 | 293,357 | +43,800 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 321,615 | 288,551 | -33,064 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 341,724 | 268,549 | -73,175 | 0.01 | 0.01 | -0.00 | sell |
| Palisades Investment Partners, LLC | 137,768 | 255,240 | +117,472 | 1.99 | 2.97 | +0.98 | buy |
| Engineers Gate Manager LP | 136,608 | 254,401 | +117,793 | 0.06 | 0.09 | +0.03 | buy |
| BARCLAYS PLC | 369,530 | 248,861 | -120,669 | 0.01 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 202,222 | 246,648 | +44,426 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 285,311 | 234,265 | -51,046 | 0.01 | 0.01 | -0.00 | sell |
| Palo Alto Investors LP | 110,719 | 230,453 | +119,734 | 0.59 | 1.05 | +0.46 | buy |
| Impax Asset Management Group plc | 225,000 | 225,000 | 0 | 0.05 | 0.05 | -0.01 | hold |
| Bank of New York Mellon Corp | 219,996 | 217,226 | -2,770 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 214,925 | +214,925 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 319,658 | 200,111 | -119,547 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 155,895 | 196,541 | +40,646 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 218,027 | 190,762 | -27,265 | 0.01 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 177,220 | 182,320 | +5,100 | 0.19 | 0.15 | -0.04 | buy |
| MARSHALL WACE, LLP | 217,171 | 178,536 | -38,635 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 149,938 | 176,908 | +26,970 | 0.09 | 0.08 | -0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 623,390 | 176,390 | -447,000 | 0.06 | 0.01 | -0.05 | sell |
| HRT FINANCIAL LP | 0 | 173,612 | +173,612 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 167,100 | 168,100 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 133,595 | 166,477 | +32,882 | 0.01 | 0.00 | -0.00 | buy |
| F/m Investments LLC | 168,416 | 164,990 | -3,426 | 0.24 | 0.33 | +0.08 | sell |
| PRUDENTIAL FINANCIAL INC | 219,745 | 162,235 | -57,510 | 0.01 | 0.01 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 158,709 | 161,705 | +2,996 | 0.92 | 0.76 | -0.16 | buy |
| CenterBook Partners LP | 0 | 157,122 | +157,122 | 0.00 | 0.25 | +0.25 | buy |
| Rafferty Asset Management, LLC | 169,208 | 152,433 | -16,775 | 0.02 | 0.02 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 125,069 | 143,817 | +18,748 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 186,000 | 140,633 | -45,367 | 3.29 | 2.49 | -0.80 | sell |
| GW&K Investment Management, LLC | 141,180 | 140,458 | -722 | 0.05 | 0.04 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 215,951 | 137,025 | -78,926 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 20,335 | 128,364 | +108,029 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,926 | 125,879 | +66,953 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 93,702 | 124,192 | +30,490 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 121,200 | +121,200 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 39,568 | 117,361 | +77,793 | 0.03 | 0.07 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 867,622 | 114,268 | -753,354 | 0.12 | 0.01 | -0.10 | sell |
| Hennion & Walsh Asset Management, Inc. | 99,229 | 113,511 | +14,282 | 0.13 | 0.11 | -0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 39,749 | 111,633 | +71,884 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 665,795 | 109,382 | -556,413 | 0.02 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,472 | 105,132 | +25,660 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 109,767 | 103,605 | -6,162 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 38,022 | 102,754 | +64,732 | 0.78 | 2.18 | +1.40 | buy |
| FEDERATED HERMES, INC. | 68,299 | 92,812 | +24,513 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 91,536 | 92,757 | +1,221 | 0.19 | 0.15 | -0.04 | buy |
| WELLS FARGO & COMPANY/MN | 158,834 | 89,406 | -69,428 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 94,832 | 86,236 | -8,596 | 0.01 | 0.01 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 85,881 | +85,881 | 0.00 | 0.02 | +0.02 | buy |
| Empowered Funds, LLC | 3,008 | 84,820 | +81,812 | 0.00 | 0.02 | +0.02 | buy |
| MACKENZIE FINANCIAL CORP | 41,390 | 75,603 | +34,213 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 73,263 | 75,096 | +1,833 | 0.02 | 0.01 | -0.01 | buy |