| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 1,003,000 | 60,000 | +943,000 | 4.46 | 0.18 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,144,822 | 1,555,013 | +589,809 | 0.07 | 0.04 | -0.03 | sell |
| D. E. Shaw & Co., Inc. | 999,491 | 1,261,004 | +261,513 | 0.04 | 0.03 | 0.00 | buy |
| Rock Springs Capital Management LP | 1,276,650 | 1,527,720 | +251,070 | 0.69 | 0.56 | -0.13 | buy |
| JANUS HENDERSON GROUP PLC | 6,845,813 | 6,966,970 | +121,157 | 0.10 | 0.07 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 553,713 | 441,267 | +112,446 | 0.04 | 0.02 | 0.00 | sell |
| NATIXIS | 40,300 | 135,000 | +94,700 | 0.01 | 0.02 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 358,613 | 435,313 | +76,700 | 1.55 | 1.11 | 0.00 | buy |
| GW&K Investment Management, LLC | 301,754 | 350,610 | +48,856 | 0.07 | 0.05 | -0.01 | buy |
| TWINBEECH CAPITAL LP | 132,628 | 171,846 | +39,218 | 0.06 | 0.05 | 0.00 | buy |
| PROFUND ADVISORS LLC | 60,529 | 89,930 | +29,401 | 0.08 | 0.07 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 277,012 | 290,911 | +13,899 | 0.03 | 0.02 | -0.01 | buy |
| ALPS ADVISORS INC | 48,112 | 54,843 | +6,731 | 0.01 | 0.01 | 0.00 | buy |
| Dana Investment Advisors, Inc. | 24,411 | 30,801 | +6,390 | 0.03 | 0.02 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 141,887 | 146,323 | +4,436 | 0.69 | 0.39 | 0.00 | buy |
| Dynamic Technology Lab Private Ltd | 15,540 | 19,537 | +3,997 | 0.03 | 0.04 | +0.01 | buy |
| OAK RIDGE INVESTMENTS LLC | 80,050 | 76,615 | -3,435 | 0.24 | 0.15 | -0.10 | sell |