| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Graham Capital Management, L.P. | 0 | 41,667,000 | +41,667,000 | 0.66 | 1.21 | +0.55 | buy |
| JANUS HENDERSON GROUP PLC | 10,394,000 | 11,391,000 | +997,000 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 7,528,622 | 9,541,270 | +2,012,648 | 0.08 | 0.07 | -0.01 | buy |
| ARMISTICE CAPITAL, LLC | 8,872,000 | 8,876,000 | +4,000 | 4.25 | 4.98 | +0.73 | buy |
| BlackRock, Inc. | 8,190,544 | 8,168,951 | -21,593 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 5,014,020 | 5,994,283 | +980,263 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 4,797,314 | 5,097,482 | +300,168 | 0.11 | 0.09 | -0.01 | buy |
| STATE STREET CORP | 3,646,715 | 3,483,176 | -163,539 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,184,898 | 2,784,000 | +599,102 | 0.07 | 0.07 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 2,706,000 | +2,706,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,702,814 | 2,495,114 | -207,700 | 0.07 | 0.05 | -0.02 | sell |
| EMERALD ADVISERS, LLC | 2,077,173 | 2,091,360 | +14,187 | 1.68 | 1.13 | -0.54 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,976,661 | 2,003,701 | +27,040 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 2,921,196 | 1,908,208 | -1,012,988 | 3.00 | 1.76 | -1.24 | sell |
| BANK OF AMERICA CORP /DE/ | 945,906 | 1,621,393 | +675,487 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,642,061 | 1,568,544 | -73,517 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 867,642 | 1,556,852 | +689,210 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 1,802,750 | 1,540,691 | -262,059 | 2.76 | 2.45 | -0.31 | sell |
| Eversept Partners, LP | 816,254 | 1,315,033 | +498,779 | 1.66 | 1.96 | +0.31 | buy |
| Nuveen, LLC | 1,203,644 | 1,194,335 | -9,309 | 0.01 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,150,000 | 1,150,000 | 0 | 0.34 | 0.29 | -0.06 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,121,886 | 1,141,428 | +19,542 | 1.43 | 1.03 | -0.40 | buy |
| D. E. Shaw & Co., Inc. | 1,713,592 | 1,130,750 | -582,842 | 0.04 | 0.02 | -0.02 | sell |
| Assenagon Asset Management S.A. | 413,514 | 1,103,075 | +689,561 | 0.01 | 0.03 | +0.01 | buy |
| FMR LLC | 1,081,702 | 1,067,773 | -13,929 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,045,700 | 1,057,700 | +12,000 | 0.04 | 0.03 | -0.01 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,002,092 | +1,002,092 | 0.00 | 0.59 | +0.59 | buy |
| Affinity Asset Advisors, LLC | 1,070,000 | 970,000 | -100,000 | 3.00 | 2.12 | -0.88 | sell |
| TWO SIGMA INVESTMENTS, LP | 768,794 | 918,713 | +149,919 | 0.03 | 0.02 | -0.01 | buy |
| Aberdeen Group plc | 480,369 | 896,594 | +416,225 | 0.02 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 498,734 | 858,834 | +360,100 | 0.02 | 0.02 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 834,252 | +834,252 | 0.00 | 0.46 | +0.46 | buy |
| Parkman Healthcare Partners LLC | 954,071 | 827,060 | -127,011 | 2.03 | 1.42 | -0.61 | sell |
| NORTHERN TRUST CORP | 808,687 | 800,628 | -8,059 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 615,295 | 771,830 | +156,535 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 852,124 | 771,522 | -80,602 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 684,543 | 771,296 | +86,753 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,181,094 | 744,654 | -436,440 | 0.08 | 0.04 | -0.04 | sell |
| MARSHALL WACE, LLP | 0 | 742,725 | +742,725 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 863,088 | 735,251 | -127,837 | 0.06 | 0.04 | -0.02 | sell |
| CITADEL ADVISORS LLC | 524,335 | 711,257 | +186,922 | 0.01 | 0.01 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 700,000 | +700,000 | 0.00 | 0.52 | +0.52 | buy |
| Cubist Systematic Strategies, LLC | 0 | 699,182 | +699,182 | 0.00 | 0.11 | +0.11 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 495,177 | 685,511 | +190,334 | 0.04 | 0.04 | -0.00 | buy |
| UBS Group AG | 704,993 | 650,281 | -54,712 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 292,991 | 604,128 | +311,137 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 665,570 | 595,681 | -69,889 | 0.01 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 821,832 | 528,526 | -293,306 | 0.01 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 672,648 | 527,538 | -145,110 | 0.03 | 0.01 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 525,771 | 516,548 | -9,223 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 534,072 | 512,681 | -21,391 | 0.06 | 0.04 | -0.02 | sell |
| Invesco Ltd. | 565,927 | 510,919 | -55,008 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 412,932 | 510,428 | +97,496 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,229,778 | 500,995 | -728,783 | 0.14 | 0.04 | -0.10 | sell |
| Squarepoint Ops LLC | 217,024 | 479,394 | +262,370 | 0.01 | 0.02 | +0.01 | buy |
| Impax Asset Management Group plc | 300,000 | 475,000 | +175,000 | 0.03 | 0.04 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,597 | 445,557 | +378,960 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 748,152 | 439,341 | -308,811 | 0.02 | 0.01 | -0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 335,959 | 432,021 | +96,062 | 0.03 | 0.03 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 593,024 | 420,512 | -172,512 | 0.01 | 0.01 | -0.01 | sell |
| ROYCE & ASSOCIATES LP | 0 | 380,997 | +380,997 | 0.00 | 0.06 | +0.06 | buy |
| Vestal Point Capital, LP | 0 | 355,000 | +355,000 | 0.00 | 0.28 | +0.28 | buy |
| PDT Partners, LLC | 309,534 | 349,577 | +40,043 | 0.39 | 0.29 | -0.10 | buy |
| ALLIANCEBERNSTEIN L.P. | 418,597 | 343,861 | -74,736 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 335,333 | +135,333 | 0.88 | 1.30 | +0.41 | buy |
| LORD, ABBETT & CO. LLC | 564,161 | 309,230 | -254,931 | 0.04 | 0.01 | -0.02 | sell |
| GW&K Investment Management, LLC | 321,162 | 282,500 | -38,662 | 0.05 | 0.04 | -0.02 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 237,487 | 276,474 | +38,987 | 5.08 | 5.10 | +0.02 | buy |
| Knott David M Jr | 228,000 | 260,000 | +32,000 | 1.93 | 1.74 | -0.18 | buy |
| PRUDENTIAL FINANCIAL INC | 243,641 | 244,256 | +615 | 0.01 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 239,045 | +239,045 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 224,936 | 237,720 | +12,784 | 0.01 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 233,942 | 231,145 | -2,797 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 399,310 | 228,093 | -171,217 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 59,832 | 208,991 | +149,159 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 163,378 | 201,508 | +38,130 | 0.03 | 0.02 | -0.00 | buy |
| Walleye Capital LLC | 269,138 | 191,867 | -77,271 | 0.05 | 0.03 | -0.03 | sell |
| F/m Investments LLC | 147,465 | 187,734 | +40,269 | 0.11 | 0.10 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 147,114 | 175,033 | +27,919 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 168,000 | +168,000 | 0.00 | 0.57 | +0.57 | buy |
| Point72 Asset Management, L.P. | 0 | 167,896 | +167,896 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 122,909 | 167,721 | +44,812 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 163,400 | +163,400 | 0.00 | 0.09 | +0.09 | buy |
| Swiss National Bank | 158,100 | 161,100 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 118,017 | 153,278 | +35,261 | 1.89 | 1.87 | -0.02 | buy |
| Man Group plc | 48,779 | 139,044 | +90,265 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 124,550 | 131,959 | +7,409 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 128,157 | +128,157 | 0.00 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 338,850 | 127,582 | -211,268 | 0.01 | 0.00 | -0.01 | sell |
| ALGERT GLOBAL LLC | 16,167 | 127,188 | +111,021 | 0.01 | 0.04 | +0.03 | buy |
| Rafferty Asset Management, LLC | 145,021 | 123,854 | -21,167 | 0.01 | 0.01 | -0.01 | sell |
| Sio Capital Management, LLC | 121,000 | 122,210 | +1,210 | 0.66 | 0.73 | +0.07 | buy |
| Engineers Gate Manager LP | 89,784 | 110,807 | +21,023 | 0.03 | 0.02 | -0.01 | buy |
| Palo Alto Investors LP | 110,719 | 110,719 | 0 | 0.38 | 0.35 | -0.03 | hold |
| Exome Asset Management LLC | 0 | 110,000 | +110,000 | 0.00 | 1.34 | +1.34 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 123,260 | 109,787 | -13,473 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 138,000 | 103,000 | -35,000 | 2.15 | 1.51 | -0.63 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 101,406 | +101,406 | 0.00 | 0.02 | +0.02 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 88,617 | 93,612 | +4,995 | 0.09 | 0.07 | -0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 88,195 | +88,195 | 0.00 | 0.09 | +0.09 | buy |