| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7,792,033 | 8,020,663 | +228,630 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 10,967,967 | 7,096,614 | -3,871,353 | 0.02 | 0.02 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,345,111 | 4,568,341 | +3,223,230 | 0.00 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 4,959,988 | 4,256,224 | -703,764 | 0.01 | 0.01 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 4,142,551 | 3,752,574 | -389,977 | 2.43 | 3.31 | +0.88 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 977,000 | 2,569,356 | +1,592,356 | 0.04 | 0.20 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,369,559 | 2,371,887 | +2,328 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,477,954 | 2,179,069 | +701,115 | 2.59 | 6.04 | +3.45 | buy |
| Kynam Capital Management, LP | 1,569,018 | 2,000,000 | +430,982 | 2.96 | 6.28 | +3.32 | buy |
| Stephens Investment Management Group LLC | 1,798,466 | 1,875,304 | +76,838 | 0.73 | 1.14 | +0.41 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,966,779 | 1,833,079 | -133,700 | 0.09 | 0.14 | +0.05 | sell |
| EMERALD ADVISERS, LLC | 1,557,196 | 1,600,886 | +43,690 | 1.46 | 2.14 | +0.68 | buy |
| ARMISTICE CAPITAL, LLC | 4,897,417 | 1,572,539 | -3,324,878 | 4.80 | 2.47 | -2.33 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,508,259 | 1,565,656 | +57,397 | 0.04 | 0.07 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,719,721 | 1,535,321 | -184,400 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,022,272 | 1,533,080 | +510,808 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 669,159 | 1,443,230 | +774,071 | 0.03 | 0.09 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 836,544 | 1,440,469 | +603,925 | 0.02 | 0.05 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,282,518 | 1,439,134 | +156,616 | 0.28 | 0.47 | +0.19 | buy |
| MARSHALL WACE, LLP | 178,536 | 1,333,207 | +1,154,671 | 0.01 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 404,805 | 1,318,616 | +913,811 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 109,382 | 1,156,960 | +1,047,578 | 0.00 | 0.03 | +0.03 | buy |
| MPM BioImpact LLC | 1,133,365 | 1,122,731 | -10,634 | 2.60 | 3.89 | +1.29 | sell |
| Nuveen, LLC | 938,569 | 1,054,633 | +116,064 | 0.01 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 945,033 | 1,032,024 | +86,991 | 1.36 | 2.06 | +0.70 | buy |
| JANE STREET GROUP, LLC | 302,280 | 938,699 | +636,419 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 781,418 | 875,008 | +93,590 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 827,278 | +827,278 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 790,812 | 827,278 | +36,466 | 0.00 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 542,610 | 798,973 | +256,363 | 1.06 | 2.47 | +1.41 | buy |
| Ensign Peak Advisors, Inc | 715,707 | 591,815 | -123,892 | 0.04 | 0.06 | +0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 520,604 | 581,393 | +60,789 | 0.01 | 0.02 | +0.01 | buy |
| Fiera Capital Corp | 900,868 | 516,997 | -383,871 | 0.09 | 0.11 | +0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 592,912 | 490,724 | -102,188 | 0.07 | 0.09 | +0.02 | sell |
| Point72 Asset Management, L.P. | 0 | 478,860 | +478,860 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 856,757 | 473,456 | -383,301 | 0.00 | 0.00 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 301,466 | 470,914 | +169,448 | 0.01 | 0.03 | +0.02 | buy |
| Legal & General Group Plc | 451,056 | 470,400 | +19,344 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 369,995 | 470,265 | +100,270 | 0.06 | 0.12 | +0.06 | buy |
| Invesco Ltd. | 523,711 | 459,315 | -64,396 | 0.00 | 0.00 | +0.00 | sell |
| Graham Capital Management, L.P. | 0 | 446,696 | +446,696 | 0.00 | 0.68 | +0.68 | buy |
| MORGAN STANLEY | 301,655 | 429,253 | +127,598 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 7,927 | 427,305 | +419,378 | 0.00 | 0.03 | +0.03 | buy |
| GW&K Investment Management, LLC | 140,458 | 404,208 | +263,750 | 0.04 | 0.18 | +0.14 | buy |
| Russell Investments Group, Ltd. | 234,265 | 395,198 | +160,933 | 0.01 | 0.02 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 214,925 | 379,611 | +164,686 | 0.00 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 375,000 | +375,000 | 0.00 | 0.87 | +0.87 | buy |
| Pictet Asset Management Holding SA | 529,757 | 344,510 | -185,247 | 0.02 | 0.02 | +0.00 | sell |
| Artia Global Partners LP | 70,700 | 339,033 | +268,333 | 0.47 | 3.66 | +3.19 | buy |
| Capricorn Fund Managers Ltd | 0 | 321,721 | +321,721 | 0.00 | 1.46 | +1.46 | buy |
| Impax Asset Management Group plc | 225,000 | 300,000 | +75,000 | 0.05 | 0.11 | +0.06 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 300,000 | 0 | 0.52 | 0.83 | +0.31 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 293,357 | 296,957 | +3,600 | 0.01 | 0.02 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 292,359 | +292,359 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 268,549 | 286,478 | +17,929 | 0.01 | 0.01 | +0.00 | buy |
| Palisades Investment Partners, LLC | 255,240 | 273,080 | +17,840 | 2.97 | 4.41 | +1.44 | buy |
| AQR CAPITAL MANAGEMENT LLC | 305,412 | 270,048 | -35,364 | 0.00 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 288,551 | 267,889 | -20,662 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 302,666 | 254,054 | -48,612 | 0.03 | 0.04 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 0 | 253,000 | +253,000 | 0.00 | 0.27 | +0.27 | buy |
| Bank of New York Mellon Corp | 217,226 | 246,485 | +29,259 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 246,648 | 244,606 | -2,042 | 0.01 | 0.02 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 925,919 | 225,583 | -700,336 | 0.01 | 0.00 | -0.01 | sell |
| HSBC HOLDINGS PLC | 396,853 | 220,611 | -176,242 | 0.01 | 0.01 | -0.00 | sell |
| Neuberger Berman Group LLC | 190,762 | 214,910 | +24,148 | 0.00 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 369,193 | 205,536 | -163,657 | 0.05 | 0.04 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 196,541 | 204,366 | +7,825 | 0.01 | 0.01 | +0.00 | buy |
| F/m Investments LLC | 164,990 | 187,574 | +22,584 | 0.33 | 0.54 | +0.22 | buy |
| Hennion & Walsh Asset Management, Inc. | 113,511 | 171,470 | +57,959 | 0.11 | 0.28 | +0.16 | buy |
| Hillsdale Investment Management Inc. | 182,320 | 167,900 | -14,420 | 0.15 | 0.22 | +0.07 | sell |
| Palo Alto Investors LP | 230,453 | 167,525 | -62,928 | 1.05 | 1.32 | +0.27 | sell |
| Swiss National Bank | 168,100 | 166,600 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| MACKENZIE FINANCIAL CORP | 75,603 | 166,571 | +90,968 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 176,908 | 166,372 | -10,536 | 0.08 | 0.11 | +0.03 | sell |
| Aquatic Capital Management LLC | 35,392 | 157,710 | +122,318 | 0.03 | 0.31 | +0.28 | buy |
| WELLS FARGO & COMPANY/MN | 89,406 | 156,246 | +66,840 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 140,633 | 147,282 | +6,649 | 2.49 | 4.42 | +1.94 | buy |
| Voleon Capital Management LP | 43,355 | 145,655 | +102,300 | 0.03 | 0.15 | +0.12 | buy |
| SEI INVESTMENTS CO | 166,477 | 142,858 | -23,619 | 0.00 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 137,025 | 142,368 | +5,343 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 161,705 | 133,866 | -27,839 | 0.76 | 1.00 | +0.24 | sell |
| FRANKLIN RESOURCES INC | 124,192 | 132,794 | +8,602 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 557,147 | 124,855 | -432,292 | 0.03 | 0.01 | -0.02 | sell |
| FEDERATED HERMES, INC. | 92,812 | 122,015 | +29,203 | 0.00 | 0.01 | +0.01 | buy |
| Calamos Advisors LLC | 54,245 | 121,755 | +67,510 | 0.01 | 0.03 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,058 | 119,331 | +79,273 | 0.00 | 0.01 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 48,185 | 119,005 | +70,820 | 0.36 | 1.49 | +1.13 | buy |
| Informed Momentum Co LLC | 0 | 117,987 | +117,987 | 0.00 | 0.60 | +0.60 | buy |
| CITIGROUP INC | 27,131 | 115,045 | +87,914 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 103,605 | 113,744 | +10,139 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 143,817 | 113,700 | -30,117 | 0.00 | 0.00 | -0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 0 | 112,000 | +112,000 | 0.00 | 0.62 | +0.62 | buy |
| Squarepoint Ops LLC | 200,111 | 109,807 | -90,304 | 0.01 | 0.01 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 104,208 | +104,208 | 0.00 | 0.04 | +0.04 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 92,757 | 97,573 | +4,816 | 0.15 | 0.27 | +0.12 | buy |
| ExodusPoint Capital Management, LP | 73,910 | 97,442 | +23,532 | 0.02 | 0.05 | +0.03 | buy |
| SummitTX Capital, L.P. | 0 | 96,018 | +96,018 | 0.00 | 0.14 | +0.14 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,132 | 95,534 | -9,598 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 75,096 | 93,981 | +18,885 | 0.01 | 0.03 | +0.01 | buy |
| 1832 Asset Management L.P. | 0 | 88,100 | +88,100 | 0.00 | 0.01 | +0.01 | buy |