| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 1,276,878 | 4,340,340 | +3,063,462 | 0.10 | 0.51 | +0.41 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,285,379 | +1,285,379 | 0.00 | 0.05 | +0.05 | buy |
| Logos Global Management LP | 0 | 1,100,000 | +1,100,000 | 0.00 | 1.72 | +1.72 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 753,795 | +753,795 | 0.00 | 0.04 | +0.04 | buy |
| FEDERATED HERMES, INC. | 41,717 | 623,815 | +582,098 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 30,980 | 365,206 | +334,226 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 332,939 | +332,939 | 0.00 | 0.24 | +0.24 | buy |
| EMERALD ADVISERS, LLC | 1,637,146 | 1,960,659 | +323,513 | 0.56 | 1.06 | +0.50 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 313,242 | +313,242 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 1,533,072 | 1,840,069 | +306,997 | 0.02 | 0.03 | +0.02 | buy |
| VANGUARD GROUP INC | 6,619,756 | 6,902,150 | +282,394 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,441 | 281,349 | +247,908 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 941,265 | 1,185,709 | +244,444 | 0.41 | 0.86 | +0.46 | buy |
| Jump Financial, LLC | 37,480 | 276,530 | +239,050 | 0.01 | 0.08 | +0.07 | buy |
| PANAGORA ASSET MANAGEMENT INC | 90,881 | 320,333 | +229,452 | 0.00 | 0.02 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 615,000 | 843,300 | +228,300 | 0.01 | 0.03 | +0.01 | buy |
| Walleye Capital LLC | 266,471 | 488,453 | +221,982 | 0.02 | 0.07 | +0.05 | buy |
| Rock Springs Capital Management LP | 4,482,265 | 4,684,476 | +202,211 | 1.11 | 2.13 | +1.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,942 | 222,470 | +197,528 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 131,506 | 326,235 | +194,729 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 174,488 | 356,708 | +182,220 | 0.02 | 0.06 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 435,641 | 603,941 | +168,300 | 0.01 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 553,300 | 720,400 | +167,100 | 0.01 | 0.02 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 7,500,000 | 7,648,000 | +148,000 | 1.61 | 2.80 | +1.19 | buy |
| CITADEL ADVISORS LLC | 640,309 | 775,089 | +134,780 | 0.01 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 74,069 | 194,663 | +120,594 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 969,892 | 1,086,067 | +116,175 | 1.09 | 1.94 | +0.85 | buy |
| MARSHALL WACE, LLP | 0 | 111,341 | +111,341 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 44,561 | 125,000 | +80,439 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 71,800 | +71,800 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,666,301 | 1,731,045 | +64,744 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 472,396 | 525,381 | +52,985 | 0.02 | 0.04 | +0.02 | buy |
| OPPENHEIMER & CO INC | 0 | 48,139 | +48,139 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 314,180 | 360,083 | +45,903 | 0.01 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 634,401 | 677,452 | +43,051 | 0.01 | 0.01 | +0.00 | buy |
| Semanteon Capital Management, LP | 0 | 36,699 | +36,699 | 0.00 | 0.35 | +0.35 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 35,748 | +35,748 | 0.00 | 0.05 | +0.05 | buy |
| Verition Fund Management LLC | 28,288 | 60,871 | +32,583 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 115,644 | 147,416 | +31,772 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 31,000 | +31,000 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 28,415 | +28,415 | 0.00 | 0.05 | +0.05 | buy |
| Birchview Capital, LP | 122,000 | 148,000 | +26,000 | 0.93 | 1.79 | +0.87 | buy |
| PDT Partners, LLC | 238,783 | 264,273 | +25,490 | 0.19 | 0.33 | +0.14 | buy |
| Virtu Financial LLC | 0 | 21,500 | +21,500 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 41,760 | 62,245 | +20,485 | 0.01 | 0.02 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 20,226 | +20,226 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 19,000 | +19,000 | 0.00 | 0.22 | +0.22 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 76,174 | 94,736 | +18,562 | 0.04 | 0.07 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,114 | 47,045 | +17,931 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 103,353 | 120,725 | +17,372 | 0.07 | 0.10 | +0.03 | buy |
| SEI INVESTMENTS CO | 14,226 | 30,592 | +16,366 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 91,464 | 107,492 | +16,028 | 0.00 | 0.01 | +0.00 | buy |
| Cerity Partners LLC | 0 | 13,748 | +13,748 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 13,685 | +13,685 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 15,580 | 28,562 | +12,982 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 44,953 | 57,601 | +12,648 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 16,884 | 29,125 | +12,241 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 12,180 | +12,180 | 0.00 | 0.03 | +0.03 | buy |
| Diversified Trust Co | 0 | 11,532 | +11,532 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 11,508 | +11,508 | 0.00 | 0.02 | +0.02 | buy |
| Mariner, LLC | 0 | 11,096 | +11,096 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 7,923 | +7,923 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 10,065 | 17,688 | +7,623 | 0.03 | 0.10 | +0.06 | buy |
| Quarry LP | 0 | 7,500 | +7,500 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 74,240 | 80,958 | +6,718 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,945 | 14,712 | +5,767 | 0.01 | 0.02 | +0.01 | buy |
| Finepoint Capital LP | 1,776,728 | 1,782,267 | +5,539 | 4.15 | 3.03 | -1.11 | buy |
| ProShare Advisors LLC | 14,457 | 18,451 | +3,994 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 16,511 | 19,969 | +3,458 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,934 | 4,999 | +3,065 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 15,062 | 17,205 | +2,143 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 469 | 1,586 | +1,117 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 22,943 | 23,938 | +995 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 37,283 | 38,144 | +861 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 19,176 | 19,730 | +554 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,273 | 2,767 | +494 | 0.00 | 0.00 | +0.00 | buy |
| Elequin Capital, LP | 0 | 462 | +462 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 458 | +458 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 61,295 | 61,695 | +400 | 0.03 | 0.04 | +0.01 | buy |
| HUNTINGTON NATIONAL BANK | 985 | 1,368 | +383 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 40,832 | 41,143 | +311 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 228 | +228 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,605 | 1,771 | +166 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 105 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 60 | 132 | +72 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 89 | 127 | +38 | 0.00 | 0.00 | +0.00 | buy |
| AGF MANAGEMENT LTD | 0 | 0 | 0 | 0.01 | 0.02 | +0.01 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 50,880 | 50,880 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 0 | 0 | 0 | 0.04 | 0.05 | +0.01 | hold |
| CANADA LIFE ASSURANCE Co | 6,902 | 6,902 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,238 | 7,238 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADVENT CAPITAL MANAGEMENT /DE/ | 0 | 0 | 0 | 0.00 | 0.08 | +0.08 | hold |
| CSS LLC/IL | 0 | 0 | 0 | 0.05 | 0.18 | +0.13 | hold |
| MassMutual Private Wealth & Trust, FSB | 235 | 235 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 70,630 | 70,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 400,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AQR Arbitrage LLC | 0 | 0 | 0 | 0.17 | 0.19 | +0.02 | hold |
| LAZARD ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.03 | 0.01 | -0.02 | hold |
| JANUS HENDERSON GROUP PLC | 31,813 | 31,813 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SILVERBACK ASSET MANAGEMENT LLC | 0 | 0 | 0 | 1.20 | 1.60 | +0.40 | hold |