| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 9,541,270 | 10,599,660 | +1,058,390 | 0.07 | 0.12 | +0.05 | buy |
| BlackRock, Inc. | 8,168,951 | 8,100,461 | -68,490 | 0.00 | 0.00 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 8,876,000 | 6,724,000 | -2,152,000 | 4.98 | 5.04 | +0.06 | sell |
| VANGUARD GROUP INC | 5,994,283 | 6,613,368 | +619,085 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 11,391,000 | 6,356,000 | -5,035,000 | 0.01 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 5,097,482 | 4,984,333 | -113,149 | 0.09 | 0.14 | +0.05 | sell |
| PERCEPTIVE ADVISORS LLC | 834,252 | 3,794,615 | +2,960,363 | 0.46 | 2.62 | +2.16 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,784,000 | 3,552,000 | +768,000 | 0.07 | 0.13 | +0.07 | buy |
| STATE STREET CORP | 3,483,176 | 3,217,839 | -265,337 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,067,773 | 2,894,148 | +1,826,375 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,908,208 | 2,164,773 | +256,565 | 1.76 | 3.02 | +1.26 | buy |
| EMERALD ADVISERS, LLC | 2,091,360 | 2,146,767 | +55,407 | 1.13 | 1.64 | +0.51 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,003,701 | 2,138,030 | +134,329 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,706,000 | 1,977,000 | -729,000 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,495,114 | 1,752,114 | -743,000 | 0.05 | 0.06 | +0.01 | sell |
| Stephens Investment Management Group LLC | 0 | 1,599,668 | +1,599,668 | 0.00 | 0.50 | +0.50 | buy |
| DEUTSCHE BANK AG\ | 516,548 | 1,599,295 | +1,082,747 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 1,315,033 | 1,417,204 | +102,171 | 1.96 | 2.59 | +0.63 | buy |
| BANK OF AMERICA CORP /DE/ | 1,621,393 | 1,398,930 | -222,463 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,556,852 | 1,273,903 | -282,949 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 35,009 | 1,201,469 | +1,166,460 | 0.00 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,141,428 | 1,200,942 | +59,514 | 1.03 | 1.48 | +0.45 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,150,000 | 1,150,000 | 0 | 0.29 | 0.34 | +0.05 | hold |
| MORGAN STANLEY | 1,568,544 | 1,117,037 | -451,507 | 0.00 | 0.00 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 771,522 | 1,084,350 | +312,828 | 0.01 | 0.02 | +0.01 | buy |
| Nuveen, LLC | 1,194,335 | 1,078,691 | -115,644 | 0.00 | 0.01 | +0.00 | sell |
| Aberdeen Group plc | 896,594 | 967,385 | +70,791 | 0.02 | 0.04 | +0.01 | buy |
| Kynam Capital Management, LP | 1,540,691 | 949,727 | -590,964 | 2.45 | 1.69 | -0.76 | sell |
| TWO SIGMA INVESTMENTS, LP | 918,713 | 928,998 | +10,285 | 0.02 | 0.03 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 744,654 | 883,672 | +139,018 | 0.04 | 0.07 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 685,511 | 857,899 | +172,388 | 0.04 | 0.06 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 858,834 | 852,202 | -6,632 | 0.02 | 0.03 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 771,296 | 848,356 | +77,060 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 800,628 | 832,079 | +31,451 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 707,460 | +707,460 | 0.00 | 0.12 | +0.12 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 0.52 | 0.64 | +0.12 | hold |
| TWO SIGMA ADVISERS, LP | 1,057,700 | 696,700 | -361,000 | 0.03 | 0.03 | +0.00 | sell |
| Pictet Asset Management Holding SA | 595,681 | 684,384 | +88,703 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,130,750 | 663,252 | -467,498 | 0.02 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 510,919 | 627,902 | +116,983 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 742,725 | 590,051 | -152,674 | 0.01 | 0.02 | +0.00 | sell |
| Qube Research & Technologies Ltd | 604,128 | 571,997 | -32,131 | 0.01 | 0.02 | +0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 432,021 | 569,695 | +137,674 | 0.03 | 0.05 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 175,033 | 565,597 | +390,564 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 510,428 | 520,592 | +10,164 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 512,681 | 512,681 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Affinity Asset Advisors, LLC | 970,000 | 500,000 | -470,000 | 2.12 | 1.11 | -1.01 | sell |
| JPMORGAN CHASE & CO | 771,830 | 493,841 | -277,989 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 650,281 | 493,073 | -157,208 | 0.00 | 0.00 | +0.00 | sell |
| Impax Asset Management Group plc | 475,000 | 475,000 | 0 | 0.04 | 0.07 | +0.03 | hold |
| Graham Capital Management, L.P. | 0 | 466,998 | +466,998 | 0.00 | 0.41 | +0.41 | buy |
| Frazier Life Sciences Management, L.P. | 1,002,092 | 392,092 | -610,000 | 0.59 | 0.28 | -0.31 | sell |
| BARCLAYS PLC | 528,526 | 349,002 | -179,524 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 827,060 | 339,764 | -487,296 | 1.42 | 0.89 | -0.52 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 328,654 | +328,654 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 343,861 | 322,115 | -21,746 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 735,251 | 318,146 | -417,105 | 0.04 | 0.03 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 228,093 | 313,377 | +85,284 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 349,577 | 281,458 | -68,119 | 0.29 | 0.42 | +0.13 | sell |
| Knott David M Jr | 260,000 | 260,000 | 0 | 1.74 | 2.60 | +0.86 | hold |
| Bank of New York Mellon Corp | 231,145 | 237,243 | +6,098 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 237,720 | 222,257 | -15,463 | 0.00 | 0.01 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 127,582 | 213,918 | +86,336 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 0 | 211,667 | +211,667 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 187,734 | 196,074 | +8,340 | 0.10 | 0.18 | +0.08 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 167,721 | 194,854 | +27,133 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 190,781 | +190,781 | 0.00 | 0.92 | +0.92 | buy |
| Hillsdale Investment Management Inc. | 163,400 | 178,400 | +15,000 | 0.09 | 0.13 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 239,045 | 172,430 | -66,615 | 0.00 | 0.00 | +0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 0 | 166,000 | +166,000 | 0.00 | 0.88 | +0.88 | buy |
| Swiss National Bank | 161,100 | 163,600 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 161,988 | +161,988 | 0.00 | 0.59 | +0.59 | buy |
| Exome Asset Management LLC | 153,278 | 156,917 | +3,639 | 1.87 | 2.48 | +0.61 | buy |
| ALGERT GLOBAL LLC | 127,188 | 153,648 | +26,460 | 0.04 | 0.06 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 128,157 | 147,348 | +19,191 | 0.02 | 0.05 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 445,557 | 145,927 | -299,630 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 244,256 | 137,611 | -106,645 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 309,230 | 135,919 | -173,311 | 0.01 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 208,991 | 133,869 | -75,122 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 131,959 | 130,021 | -1,938 | 0.00 | 0.00 | +0.00 | sell |
| Lisanti Capital Growth, LLC | 0 | 129,512 | +129,512 | 0.00 | 0.76 | +0.76 | buy |
| ROYCE & ASSOCIATES LP | 380,997 | 123,250 | -257,747 | 0.06 | 0.03 | -0.03 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 122,029 | +122,029 | 0.00 | 0.01 | +0.01 | buy |
| GW&K Investment Management, LLC | 282,500 | 117,869 | -164,631 | 0.04 | 0.02 | -0.01 | sell |
| Squarepoint Ops LLC | 479,394 | 114,477 | -364,917 | 0.02 | 0.01 | -0.01 | sell |
| Palo Alto Investors LP | 110,719 | 110,719 | 0 | 0.35 | 0.49 | +0.14 | hold |
| TUDOR INVESTMENT CORP ET AL | 201,508 | 95,747 | -105,761 | 0.02 | 0.01 | -0.01 | sell |
| Cinctive Capital Management LP | 0 | 94,656 | +94,656 | 0.00 | 0.11 | +0.11 | buy |
| Y-Intercept (Hong Kong) Ltd | 68,000 | 94,325 | +26,325 | 0.02 | 0.05 | +0.03 | buy |
| Assenagon Asset Management S.A. | 1,103,075 | 93,355 | -1,009,720 | 0.03 | 0.00 | -0.02 | sell |
| Rafferty Asset Management, LLC | 123,854 | 90,250 | -33,604 | 0.01 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 70,559 | 89,443 | +18,884 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,995 | 89,328 | -411,667 | 0.04 | 0.01 | -0.03 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 93,612 | 84,097 | -9,515 | 0.07 | 0.11 | +0.03 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 81,825 | +81,825 | 0.00 | 0.05 | +0.05 | buy |
| Penserra Capital Management LLC | 0 | 80,556 | +80,556 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,192 | 79,936 | +7,744 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 71,372 | 79,444 | +8,072 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 68,820 | 74,683 | +5,863 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 71,030 | +71,030 | 0.00 | 0.18 | +0.18 | buy |